Drug releasing systems in cardiovascular tissue engineering

•  Introduction ‐  Drug delivery systems in cardiovascular applications–what are the aims/targets? ‐  Approaches, methodologies and manufacturing techniques •  Drug and molecules released ‐  Steroids ‐  Growth factors ‐  Heparin ‐  Nitric oxide ‐  Gene delivery •  Conclusion •  Acknowledgements

[1]  A. Carpentier,et al.  Association between a cell-seeded collagen matrix and cellular cardiomyoplasty for myocardial support and regeneration. , 2007, Tissue engineering.

[2]  Richard T. Lee,et al.  Local Controlled Intramyocardial Delivery of Platelet-Derived Growth Factor Improves Postinfarction Ventricular Function Without Pulmonary Toxicity , 2006, Circulation.

[3]  Linshu Liu,et al.  Hyaluronate-heparin conjugate gels for the delivery of basic fibroblast growth factor (FGF-2). , 2002, Journal of biomedical materials research.

[4]  D. Mooney,et al.  Hydrogels for tissue engineering. , 2001, Chemical Reviews.

[5]  V. Fuster,et al.  Syndromes of accelerated atherosclerosis: role of vascular injury and smooth muscle cell proliferation. , 1990, Journal of the American College of Cardiology.

[6]  R. Klabunde.  Cardiovascular Physiology Concepts , 2021 .

[7]  S. Ferrari,et al.  ExGen 500 is an efficient vector for gene delivery to lung epithelial cells in vitro and in vivo , 1997, Gene Therapy.

[8]  G. Kwon,et al.  Encapsulation of plasmid DNA in biodegradable poly(D, L-lactic-co-glycolic acid) microspheres as a novel approach for immunogene delivery. , 1999, Journal of controlled release : official journal of the Controlled Release Society.

[9]  Ű. Langel,et al.  Targeting of cancer-related proteins with PNA oligomers. , 2001, Current cancer drug targets.

[10]  William R Wagner,et al.  A seeding device for tissue engineered tubular structures. , 2006, Biomaterials.

[11]  Jae‐Hyung Jang,et al.  Surface adsorption of DNA to tissue engineering scaffolds for efficient gene delivery. , 2006, Journal of biomedical materials research. Part A.

[12]  M. Makuuchi,et al.  Hematopoietic stem cells differentiate into vascular cells that participate in the pathogenesis of atherosclerosis , 2002, Nature Medicine.

[13]  F. Papadimitrakopoulos,et al.  Dexamethasone-loaded poly(lactic-co-glycolic) acid microspheres/poly(vinyl alcohol) hydrogel composite coatings for inflammation control. , 2004, Diabetes technology & therapeutics.

[14]  A. Mikos,et al.  Platelet adhesion on a bioresorbable poly(propylene fumarate-co-ethylene glycol) copolymer. , 1999, Biomaterials.

[15]  H. Kleinman,et al.  Complex Extracellular Matrices Promote Tissue‐Specific Stem Cell Differentiation , 2005, Stem cells.

[16]  Yasuhiko Tabata,et al.  Tissue regeneration based on tissue engineering technology , 2004, Congenital anomalies.

[17]  Richard T. Lee,et al.  Injectable Self-Assembling Peptide Nanofibers Create Intramyocardial Microenvironments for Endothelial Cells , 2005, Circulation.

[18]  D. Scherman,et al.  A versatile vector for gene and oligonucleotide transfer into cells in culture and in vivo: polyethylenimine. , 1995, Proceedings of the National Academy of Sciences of the United States of America.

[19]  K E Healy,et al.  A biodegradable polymer scaffold for delivery of osteotropic factors. , 2000, Biomaterials.

[20]  M. Simionescu,et al.  Designing of ‘intelligent’ liposomes for efficient delivery of drugs , 2002, Journal of cellular and molecular medicine.

[21]  A. Gaspardone,et al.  Prevention of restenosis after stenting: the emerging role of inflammation , 2004, Coronary artery disease.

[22]  Y. Dor,et al.  Making vascular networks in the adult: branching morphogenesis without a roadmap. , 2003, Trends in cell biology.

[23]  D. Ingber,et al.  Prevascularization of porous biodegradable polymers , 1993, Biotechnology and bioengineering.

[24]  A. Mikos,et al.  Osteoblastic phenotype of rat marrow stromal cells cultured in the presence of dexamethasone, β‐glycerolphosphate, and L‐ascorbic acid , 1998, Journal of cellular biochemistry.

[25]  K. Kihara,et al.  Down-regulation of vascular endothelial growth factor in renal cell carcinoma cells by glucocorticoids , 2004, Molecular and Cellular Endocrinology.

[26]  N. Hibino,et al.  Tissue-engineered vascular autograft: inferior vena cava replacement in a dog model. , 2001, Tissue engineering.

[27]  R Langer,et al.  Creation of viable pulmonary artery autografts through tissue engineering. , 1998, The Journal of thoracic and cardiovascular surgery.

[28]  H. Greisler,et al.  Biointeractive polymers and tissue engineered blood vessels. , 1996, Biomaterials.

[29]  Aldo R Boccaccini,et al.  Assessment of polyglycolic acid mesh and bioactive glass for soft-tissue engineering scaffolds. , 2004, Biomaterials.

[30]  D J Mooney,et al.  Release from alginate enhances the biological activity of vascular endothelial growth factor. , 1998, Journal of biomaterials science. Polymer edition.

[31]  D H Kohn,et al.  Sustained release of vascular endothelial growth factor from mineralized poly(lactide-co-glycolide) scaffolds for tissue engineering. , 2000, Biomaterials.

[32]  H. Suh,et al.  Bacterial adhesion on PEG modified polyurethane surfaces. , 1998, Biomaterials.

[33]  Alain Carpentier,et al.  Myocardial Assistance by Grafting a New Bioartificial Upgraded Myocardium (MAGNUM trial): clinical feasibility study. , 2008, The Annals of thoracic surgery.

[34]  A. Perets,et al.  Enhancing the vascularization of three-dimensional porous alginate scaffolds by incorporating controlled release basic fibroblast growth factor microspheres. , 2003, Journal of biomedical materials research. Part A.

[35]  R. Browne,et al.  Subperiosteal behaviour of alginate and cellulose wound dressing materials. , 1995, Biomaterials.

[36]  Jae-Hyung Jang,et al.  Controllable delivery of non-viral DNA from porous scaffolds. , 2003, Journal of controlled release : official journal of the Controlled Release Society.

[37]  D. Fischer,et al.  A Novel Non-Viral Vector for DNA Delivery Based on Low Molecular Weight, Branched Polyethylenimine: Effect of Molecular Weight on Transfection Efficiency and Cytotoxicity , 1999, Pharmaceutical Research.

[38]  K. Matsumoto,et al.  Suppression of tumor metastasis by NK4 plasmid DNA released from cationized gelatin , 2004, Gene Therapy.

[39]  Jae‐Hyung Jang,et al.  Patterned PLG substrates for localized DNA delivery and directed neurite extension. , 2007, Biomaterials.

[40]  Narutoshi Hibino,et al.  The tissue-engineered vascular graft using bone marrow without culture. , 2005, The Journal of thoracic and cardiovascular surgery.

[41]  W. Anderson,et al.  Site-directed neovessel formation in vivo. , 1988, Science.

[42]  K. Olbrich,et al.  Long- and short-term effects of biological hydrogels on capsule microvascular density around implants in rats. , 2001, Journal of biomedical materials research.

[43]  Tae Gwan Park,et al.  Immobilization of cell adhesive RGD peptide onto the surface of highly porous biodegradable polymer scaffolds fabricated by a gas foaming/salt leaching method. , 2004, Biomaterials.

[44]  S. S. Davis,et al.  An introduction to tissue-biomaterial interactions , 2002 .

[45]  David J Mooney,et al.  Engineering vascular networks in porous polymer matrices. , 2002, Journal of biomedical materials research.

[46]  S. Ramakrishna,et al.  Characterization of the surface biocompatibility of the electrospun PCL-collagen nanofibers using fibroblasts. , 2005, Biomacromolecules.

[47]  Jian Yang,et al.  Synthesis and evaluation of poly(diol citrate) biodegradable elastomers. , 2006, Biomaterials.

[48]  Y. Ikada,et al.  Controlled release of growth factors based on biodegradation of gelatin hydrogel , 2001, Journal of biomaterials science. Polymer edition.

[49]  J. Winkles,et al.  FGF-1 affixation stimulates ePTFE endothelialization without intimal hyperplasia. , 1994, The Journal of surgical research.

[50]  Chih‐Yen Chen,et al.  Dexamethasone Inhibits Epidermal Growth Factor-Stimulated Gastric Epithelial Cell Proliferation , 2007, Journal of Pharmacology and Experimental Therapeutics.

[51]  David Bonnafous,et al.  Sustained delivery of growth factors from methylidene malonate 2.1.2-based polymers. , 2006, Biomaterials.

[52]  Jeffrey Bonadio,et al.  Localized, direct plasmid gene delivery in vivo: prolonged therapy results in reproducible tissue regeneration , 1999, Nature Medicine.

[53]  J. Smink,et al.  Glucocorticoids inhibit vascular endothelial growth factor expression in growth plate chondrocytes , 2002, Molecular and Cellular Endocrinology.

[54]  Spencer B. King,et al.  Restenosis After Coronary Angioplasty: Potential Biologic Determinants and Role of Intimal Hyperplasia , 1989 .

[55]  David J Mooney,et al.  Comparison of vascular endothelial growth factor and basic fibroblast growth factor on angiogenesis in SCID mice. , 2003, Journal of controlled release : official journal of the Controlled Release Society.

[56]  S. W. Kim,et al.  Biodegradable Polyester, Poly[α-(4-Aminobutyl)-l-Glycolic Acid], as a Non-Toxic Gene Carrier , 2004, Pharmaceutical Research.

[57]  A. Lumsden,et al.  Basic fibroblast growth factor coating and endothelial cell seeding of a decellularized heparin-coated vascular graft. , 2004, Artificial organs.

[58]  Y. Tabata,et al.  Controlled release of plasmid DNA from cationized gelatin hydrogels based on hydrogel degradation. , 2002, Journal of controlled release : official journal of the Controlled Release Society.

[59]  Wei He,et al.  Tubular nanofiber scaffolds for tissue engineered small-diameter vascular grafts. , 2009, Journal of biomedical materials research. Part A.

[60]  T. Park,et al.  Dexamethasone-releasing biodegradable polymer scaffolds fabricated by a gas-foaming/salt-leaching method. , 2003, Biomaterials.

[61]  Eben Alsberg,et al.  Degradation of Partially Oxidized Alginate and Its Potential Application for Tissue Engineering , 2001, Biotechnology progress.

[62]  A. Akgerman,et al.  Active growth factor delivery from poly(D,L-lactide-co-glycolide) foams prepared in supercritical CO(2). , 2000, Journal of controlled release : official journal of the Controlled Release Society.

[63]  A. Russell,et al.  Creating molecular barriers to acute platelet deposition on damaged arteries with reactive polyethylene glycol. , 1998, Journal of biomedical materials research.

[64]  Milica Radisic,et al.  Oxygen gradients correlate with cell density and cell viability in engineered cardiac tissue , 2006, Biotechnology and bioengineering.

[65]  Gordana Vunjak-Novakovic,et al.  Perfusion improves tissue architecture of engineered cardiac muscle. , 2002, Tissue engineering.

[66]  William V Giannobile,et al.  Nano-fibrous scaffold for controlled delivery of recombinant human PDGF-BB. , 2006, Journal of controlled release : official journal of the Controlled Release Society.

[67]  Yasuhiko Tabata,et al.  Current status of regenerative medical therapy based on drug delivery technology. , 2008, Reproductive biomedicine online.

[68]  K. Leong,et al.  Controlled release of heparin from poly(epsilon-caprolactone) electrospun fibers. , 2006, Biomaterials.

[69]  Lakeshia J Taite,et al.  Nitric oxide-releasing polyurethane-PEG copolymer containing the YIGSR peptide promotes endothelialization with decreased platelet adhesion. , 2008, Journal of biomedical materials research. Part B, Applied biomaterials.

[70]  P. Madeddu.  Therapeutic angiogenesis and vasculogenesis for tissue regeneration , 2005, Experimental physiology.

[71]  Y. M. Elçin,et al.  Extensive in vivo angiogenesis following controlled release of human vascular endothelial cell growth factor: implications for tissue engineering and wound healing. , 2001, Artificial organs.

[72]  K. M. Davies,et al.  "NONOates" (1-substituted diazen-1-ium-1,2-diolates) as nitric oxide donors: convenient nitric oxide dosage forms. , 1996, Methods in enzymology.

[73]  R. Levy,et al.  DNA delivery from an intravascular stent with a denatured collagen-polylactic-polyglycolic acid-controlled release coating: mechanisms of enhanced transfection , 2003, Gene Therapy.

[74]  R. Langer,et al.  A tough biodegradable elastomer , 2002, Nature Biotechnology.

[75]  Narutoshi Hibino,et al.  Midterm clinical result of tissue-engineered vascular autografts seeded with autologous bone marrow cells. , 2005, The Journal of thoracic and cardiovascular surgery.

[76]  David J Mooney,et al.  Synthetic extracellular matrices for tissue engineering and regeneration. , 2004, Current topics in developmental biology.

[77]  J. Nah,et al.  Artery wall binding peptide-poly(ethylene glycol)-grafted-poly(L-lysine)-based gene delivery to artery wall cells. , 2002, Journal of controlled release : official journal of the Controlled Release Society.

[78]  John Layman,et al.  Release of tetracycline hydrochloride from electrospun poly(ethylene-co-vinylacetate), poly(lactic acid), and a blend. , 2002, Journal of controlled release : official journal of the Controlled Release Society.

[79]  D. Mooney,et al.  Controlled delivery of inductive proteins, plasmid DNA and cells from tissue engineering matrices. , 1999, Journal of periodontal research.

[80]  R Langer,et al.  Biomimetic approach to cardiac tissue engineering , 2007, Philosophical Transactions of the Royal Society B: Biological Sciences.

[81]  W. Mark Saltzman,et al.  Controlled DNA Delivery Systems , 1999, Pharmaceutical Research.

[82]  A. Gaspardone,et al.  Coronary stenting and inflammation. , 2005, The American journal of cardiology.

[83]  J. Hubbell,et al.  Development of fibrin derivatives for controlled release of heparin-binding growth factors. , 2000, Journal of controlled release : official journal of the Controlled Release Society.

[84]  Matthias P Lutolf,et al.  Biopolymeric delivery matrices for angiogenic growth factors. , 2003, Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology.

[85]  J. Vacanti,et al.  Transplantation of hepatocytes using porous, biodegradable sponges. , 1994, Transplantation proceedings.

[86]  Yi Hong,et al.  Fabrication of cell microintegrated blood vessel constructs through electrohydrodynamic atomization. , 2007, Biomaterials.

[87]  W. Zimmermann,et al.  Three-dimensional engineered heart tissue from neonatal rat cardiac myocytes. , 2000, Biotechnology and bioengineering.

[88]  Seeram Ramakrishna,et al.  Electrospun nanofiber fabrication as synthetic extracellular matrix and its potential for vascular tissue engineering. , 2004, Tissue engineering.

[89]  M A Moses,et al.  Tissue engineering of autologous aorta using a new biodegradable polymer. , 1999, The Annals of thoracic surgery.

[90]  D. Mooney,et al.  Polymeric system for dual growth factor delivery , 2001, Nature Biotechnology.

[91]  P. Holvoet,et al.  Gene therapy approaches for cardiovascular diseases. , 2004, Current gene therapy.

[92]  Jae‐Hyung Jang,et al.  Intramuscular delivery of DNA releasing microspheres: microsphere properties and transgene expression. , 2006, Journal of controlled release : official journal of the Controlled Release Society.

[93]  Lisbeth Grøndahl,et al.  Controlled release of heparin from poly(ε-caprolactone) electrospun fibers , 2006 .

[94]  Kevin E Healy,et al.  Nanoparticulate DNA packaging using terpolymers of poly(lysine-g-(lactide-b-ethylene glycol)). , 2003, Bioconjugate chemistry.

[95]  Y. Tabata,et al.  Controlled Release of Hepatocyte Growth Factor from Gelatin Hydrogels Based on Hydrogel Degradation , 2001, Journal of drug targeting.

[96]  C. Allen,et al.  Epidermal growth factor-conjugated poly(ethylene glycol)-block- poly(delta-valerolactone) copolymer micelles for targeted delivery of chemotherapeutics. , 2006, Bioconjugate chemistry.

[97]  Irving M Shapiro,et al.  Decellularized vein as a potential scaffold for vascular tissue engineering. , 2004, Journal of vascular surgery.

[98]  J. Hubbell,et al.  Covalently conjugated VEGF--fibrin matrices for endothelialization. , 2001, Journal of controlled release : official journal of the Controlled Release Society.

[99]  Glenn D Prestwich,et al.  Injectable glycosaminoglycan hydrogels for controlled release of human basic fibroblast growth factor. , 2005, Biomaterials.

[100]  Robert J. Lee,et al.  Folate receptor-targeted liposomes as vectors for therapeutic agents. , 2002, Biotechnology annual review.

[101]  J. Bonadio.  Tissue engineering via local gene delivery , 2000, Journal of Molecular Medicine.

[102]  R. Black,et al.  PCL-PU composite vascular scaffold production for vascular tissue engineering: attachment, proliferation and bioactivity of human vascular endothelial cells. , 2006, Biomaterials.

[103]  D J Mooney,et al.  Spatiotemporal control of vascular endothelial growth factor delivery from injectable hydrogels enhances angiogenesis , 2007, Journal of thrombosis and haemostasis : JTH.

[104]  Lissy K Krishnan,et al.  Vascular tissue generation in response to signaling molecules integrated with a novel poly(ε‐caprolactone)–fibrin hybrid scaffold , 2007, Journal of tissue engineering and regenerative medicine.

[105]  Y. Ikada,et al.  Bone regeneration by transforming growth factor beta1 released from a biodegradable hydrogel. , 2000, Journal of controlled release : official journal of the Controlled Release Society.

[106]  M. Hedley.  Formulations containing poly(lactide-co-glycolide) and plasmid DNA expression vectors , 2003, Expert opinion on biological therapy.

[107]  Fen Chen,et al.  Biomimetic approach to cardiac tissue engineering: oxygen carriers and channeled scaffolds. , 2006, Tissue engineering.

[108]  N. Gadegaard,et al.  3D polymer scaffolds for tissue engineering. , 2006, Nanomedicine.

[109]  V. Sasisekharan,et al.  Structural specificity of heparin binding in the fibroblast growth factor family of proteins , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[110]  Lixin Yang,et al.  Biodegradable electrospun fibers for drug delivery. , 2003, Journal of controlled release : official journal of the Controlled Release Society.

[111]  J. Fowlkes,et al.  Exploring the interface between metallo-proteinase activity and growth factor and cytokine bioavailability. , 2002, Cytokine & growth factor reviews.

[112]  M. Benet,et al.  Stability of PEI-DNA and DOTAP-DNA complexes: effect of alkaline pH, heparin and serum. , 2001, Journal of controlled release : official journal of the Controlled Release Society.

[113]  Hussila Keshaw,et al.  Release of angiogenic growth factors from cells encapsulated in alginate beads with bioactive glass. , 2005, Biomaterials.

[114]  Cato T Laurencin,et al.  Bioresorbable nanofiber-based systems for wound healing and drug delivery: optimization of fabrication parameters. , 2004, Journal of biomedical materials research. Part B, Applied biomaterials.

[115]  Loren E Wold,et al.  Thickening of the infarcted wall by collagen injection improves left ventricular function in rats: a novel approach to preserve cardiac function after myocardial infarction. , 2005, Journal of the American College of Cardiology.

[116]  Sumona Sarkar,et al.  Development and characterization of a porous micro-patterned scaffold for vascular tissue engineering applications. , 2006, Biomaterials.

[117]  B. Conklin,et al.  Development and evaluation of a novel decellularized vascular xenograft. , 2002, Medical engineering & physics.

[118]  M. Kotaki,et al.  A review on polymer nanofibers by electrospinning and their applications in nanocomposites , 2003 .

[119]  Carlos E Semino,et al.  The effect of functionalized self-assembling peptide scaffolds on human aortic endothelial cell function. , 2005, Biomaterials.

[120]  R. Kamm,et al.  Primary sequence of ionic self-assembling peptide gels affects endothelial cell adhesion and capillary morphogenesis. , 2008, Journal of biomedical materials research. Part A.

[121]  Y. Lim,et al.  Biodegradable polyester, poly[alpha-(4-aminobutyl)-L-glycolic acid], as a non-toxic gene carrier. , 2000, Pharmaceutical research.

[122]  Debby Gawlitta,et al.  Properties of engineered vascular constructs made from collagen, fibrin, and collagen-fibrin mixtures. , 2004, Biomaterials.

[123]  F. Gu,et al.  Sustained delivery of vascular endothelial growth factor with alginate beads. , 2004, Journal of controlled release : official journal of the Controlled Release Society.

[124]  Aldo R. Boccaccini,et al.  Bioresorbable and bioactive polymer/Bioglass® composites with tailored pore structure for tissue engineering applications , 2003 .

[125]  A. E. Elçin,et al.  Localized angiogenesis induced by human vascular endothelial growth factor-activated PLGA sponge. , 2006, Tissue engineering.

[126]  F. Gu,et al.  Maintenance of vascular endothelial growth factor and potentially other therapeutic proteins bioactivity during a photo-initiated free radical cross-linking reaction forming biodegradable elastomers. , 2007, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

[127]  T. Ochiya,et al.  New delivery system for plasmid DNA in vivo using atelocollagen as a carrier material: the Minipellet , 1999, Nature Medicine.

[128]  Jiawei Wang,et al.  Novel chitosan/collagen scaffold containing transforming growth factor-beta1 DNA for periodontal tissue engineering. , 2006, Biochemical and biophysical research communications.

[129]  J. Hubbell,et al.  Human endothelial cell interactions with surface-coupled adhesion peptides on a nonadhesive glass substrate and two polymeric biomaterials. , 1991, Journal of biomedical materials research.

[130]  David J Mooney,et al.  Controlling alginate gel degradation utilizing partial oxidation and bimodal molecular weight distribution. , 2005, Biomaterials.

[131]  D. Mooney,et al.  Host Immune Competence and Local Ischemia Affects the Functionality of Engineered Vasculature , 2007, Microcirculation.

[132]  S. Seigneurin-Venin,et al.  Transfection of large plasmids in primary human myoblasts , 2001, Gene Therapy.

[133]  L. Koole,et al.  Human endothelial cell attachment and proliferation on a novel vascular graft prototype. , 2004, Journal of biomedical materials research. Part A.

[134]  D. Mooney,et al.  Tissue engineering strategies for in vivo neovascularisation , 2002, Expert opinion on biological therapy.

[135]  A. Quyyumi,et al.  Intracoronary basic fibroblast growth factor enhances myocardial collateral perfusion in dogs. , 2000, Journal of the American College of Cardiology.

[136]  J. Fallon,et al.  Endothelial cell seeding fails to attenuate intimal thickening in balloon-injured rabbit arteries. , 1995, Journal of vascular surgery.

[137]  G. Molema,et al.  In Vivo Characteristics of Cationic Liposomes as Delivery Vectors for Gene Therapy , 2002, Pharmaceutical Research.

[138]  A A Poot,et al.  Improved endothelialization of vascular grafts by local release of growth factor from heparinized collagen matrices. , 1998, Journal of controlled release : official journal of the Controlled Release Society.

[139]  Yasuhiko Tabata,et al.  Significance of release technology in tissue engineering. , 2005, Drug discovery today.

[140]  W. Saltzman,et al.  Gene expression and mucosal immune responses after vaginal DNA immunization in mice using a controlled delivery matrix. , 2003, Journal of controlled release : official journal of the Controlled Release Society.

[141]  J. Itskovitz‐Eldor,et al.  Differentiation of human embryonic stem cells on three-dimensional polymer scaffolds , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[142]  A. Forbes,et al.  In vitro and in vivo analysis of macroporous biodegradable poly(D,L-lactide-co-glycolide) scaffolds containing bioactive glass. , 2005, Journal of biomedical materials research. Part A.

[143]  Joel Rosenblatt,et al.  Incorporation of drugs in an amorphous state into electrospun nanofibers composed of a water-insoluble, nonbiodegradable polymer. , 2003, Journal of controlled release : official journal of the Controlled Release Society.

[144]  J. Gehl,et al.  Electric pulse-mediated gene delivery to various animal tissues. , 2005, Advances in genetics.

[145]  Ge Zhang,et al.  Matrices and scaffolds for drug delivery in vascular tissue engineering. , 2007, Advanced drug delivery reviews.

[146]  S. Epstein,et al.  Comparative effects of basic fibroblast growth factor and vascular endothelial growth factor on coronary collateral development and the arterial response to injury. , 1996, Circulation.

[147]  J. Hubbell,et al.  Surface characteristics and biocompatibility of lactide-based poly(ethylene glycol) scaffolds for tissue engineering. , 1998, Journal of biomaterials science. Polymer edition.

[148]  P. Marschall,et al.  Transfer of YACs up to 2.3 Mb intact into human cells with polyethylenimine , 1999, Gene Therapy.

[149]  R. Bartrons,et al.  Single-stranded DNA condensed with poly-L-lysine results in nanometric particles that are significantly smaller, more stable in physiological ionic strength fluids and afford higher efficiency of gene delivery than their double-stranded counterparts. , 2002, Biochimica et biophysica acta.

[150]  J. Itskovitz‐Eldor,et al.  Three‐dimensional porous alginate scaffolds provide a conducive environment for generation of well‐vascularized embryoid bodies from human embryonic stem cells , 2004, Biotechnology and bioengineering.

[151]  Robert Langer,et al.  Local delivery of basic fibroblast growth factor increases both angiogenesis and engraftment of hepatocytes in tissue-engineered polymer devices1 , 2002, Transplantation.

[152]  S. Verma,et al.  Nitric oxide-eluting polyurethanes--vascular grafts of the future? , 2005, The New England journal of medicine.

[153]  F. Andreopoulos,et al.  Delivery of basic fibroblast growth factor (bFGF) from photoresponsive hydrogel scaffolds. , 2006, Biomaterials.

[154]  Kwangsok Kim,et al.  Incorporation and controlled release of a hydrophilic antibiotic using poly(lactide-co-glycolide)-based electrospun nanofibrous scaffolds. , 2004, Journal of controlled release : official journal of the Controlled Release Society.

[155]  David J. Mooney,et al.  DNA delivery from polymer matrices for tissue engineering , 1999, Nature Biotechnology.

[156]  Jian Yang,et al.  Hemocompatibility evaluation of poly(diol citrate) in vitro for vascular tissue engineering. , 2007, Journal of biomedical materials research. Part A.

[157]  L. Hillis,et al.  Restenosis after successful coronary angioplasty. Pathophysiology and prevention. , 1988, The New England journal of medicine.

[158]  A. Clowes,et al.  Suppression by heparin of smooth muscle cell proliferation in injured arteries , 1977, Nature.

[159]  Milica Radisic,et al.  High-density seeding of myocyte cells for cardiac tissue engineering. , 2003, Biotechnology and bioengineering.

[160]  J. Guan,et al.  Biodegradable elastomeric scaffolds with basic fibroblast growth factor release. , 2007, Journal of controlled release : official journal of the Controlled Release Society.

[161]  H F Sailer,et al.  Slow and continuous application of human recombinant bone morphogenetic protein via biodegradable poly(lactide-co-glycolide) foamspheres. , 2002, International journal of oral and maxillofacial surgery.

[162]  J. Loscalzo.  Nitric oxide insufficiency, platelet activation, and arterial thrombosis. , 2001, Circulation research.

[163]  Philippe Leboulch,et al.  Angiogenic synergism, vascular stability and improvement of hind-limb ischemia by a combination of PDGF-BB and FGF-2 , 2003, Nature Medicine.

[164]  Hamidreza Ghandehari,et al.  Controlled Release of Plasmid DNA from a Genetically Engineered Silk-Elastinlike Hydrogel , 2002, Pharmaceutical Research.

[165]  S. Koch,et al.  Enhancing angiogenesis in collagen matrices by covalent incorporation of VEGF , 2006, Journal of materials science. Materials in medicine.

[166]  N. Rainov,et al.  Vector delivery methods and targeting strategies for gene therapy of brain tumors. , 2001, Current gene therapy.

[167]  Tae Gwan Park,et al.  PEG grafted polylysine with fusogenic peptide for gene delivery: high transfection efficiency with low cytotoxicity. , 2002, Journal of controlled release : official journal of the Controlled Release Society.

[168]  Jin-Seok Kim,et al.  Pluronic-grafted poly-(L)-lysine as a new synthetic gene carrier. , 2003, Journal of biomedical materials research. Part A.

[169]  D. Mooney,et al.  Bone regeneration in a rat cranial defect with delivery of PEI-condensed plasmid DNA encoding for bone morphogenetic protein-4 (BMP-4) , 2005, Gene Therapy.

[170]  R. Bretzel,et al.  Polymers for Induction of Revascularization in the Rat Fascial Flap: Application of Vascular Endothelial Growth Factor and Pancreatic Islet Cells , 2003, Cell transplantation.

[171]  S. Carotta,et al.  Different behavior of branched and linear polyethylenimine for gene delivery in vitro and in vivo , 2001, The journal of gene medicine.

[172]  Ngan F Huang,et al.  Injectable biopolymers enhance angiogenesis after myocardial infarction. , 2005, Tissue engineering.

[173]  Tae Gwan Park,et al.  Hyaluronic acid modified biodegradable scaffolds for cartilage tissue engineering. , 2005, Biomaterials.

[174]  Hyun Jung Chung,et al.  Heparin-immobilized biodegradable scaffolds for local and sustained release of angiogenic growth factor. , 2006, Journal of biomedical materials research. Part A.

[175]  Ikada,et al.  Protein release from gelatin matrices. , 1998, Advanced drug delivery reviews.

[176]  Diane J Burgess,et al.  Concurrent delivery of dexamethasone and VEGF for localized inflammation control and angiogenesis. , 2007, Journal of controlled release : official journal of the Controlled Release Society.

[177]  Hyun Chul Lee,et al.  Remission in models of type 1 diabetes by gene therapy using a single-chain insulin analogue , 2000, Nature.

[178]  Ge Jiang,et al.  Preparation and characterization of poly(D,L-lactide-co-glycolide) microspheres for controlled release of human growth hormone , 2008, AAPS PharmSciTech.

[179]  J. K. Leach,et al.  Proangiogenic Potential of a Collagen/Bioactive Glass Substrate , 2008, Pharmaceutical Research.

[180]  David Dean,et al.  Bone formation in transforming growth factor beta-1-coated porous poly(propylene fumarate) scaffolds. , 2002, Journal of biomedical materials research.

[181]  S. Badylak,et al.  Endothelial cell adherence to small intestinal submucosa: an acellular bioscaffold. , 1999, Biomaterials.

[182]  Ching-Pin Chang,et al.  Injectable bioartificial myocardial tissue for large-scale intramural cell transfer and functional recovery of injured heart muscle. , 2004, The Journal of thoracic and cardiovascular surgery.

[183]  E. Minar,et al.  Clinical in vitro endothelialization of femoropopliteal bypass grafts: an actuarial follow-up over three years. , 1994, Journal of vascular surgery.

[184]  David A. Puleo,et al.  An Introduction To Tissue-Biomaterial Interactions: Tissue-Biomaterial , 2003 .

[185]  Benjamin Chu,et al.  Antithrombogenic property of bone marrow mesenchymal stem cells in nanofibrous vascular grafts , 2007, Proceedings of the National Academy of Sciences.

[186]  J L Cleland,et al.  Development of poly-(D,L-lactide--coglycolide) microsphere formulations containing recombinant human vascular endothelial growth factor to promote local angiogenesis. , 2001, Journal of controlled release : official journal of the Controlled Release Society.

[187]  L. Keefer,et al.  Chemistry of the nitric oxide-releasing diazeniumdiolate ("nitrosohydroxylamine") functional group and its oxygen-substituted derivatives. , 2002, Chemical reviews.

[188]  M. Pishko,et al.  Solvent-Free Protein Encapsulation within Biodegradable Polymer Foams , 2004, Drug delivery.

[189]  D. Carlo,et al.  Strength of conjugate binding to plasmid DNA affects degradation rate and expression level in vivo. , 2000, Biochimica et biophysica acta.

[190]  Theo Kofidis,et al.  Novel Injectable Bioartificial Tissue Facilitates Targeted, Less Invasive, Large-Scale Tissue Restoration on the Beating Heart After Myocardial Injury , 2005, Circulation.

[191]  R Langer,et al.  Selective differentiation of mammalian bone marrow stromal cells cultured on three-dimensional polymer foams. , 2001, Journal of biomedical materials research.

[192]  T. Park.  Perfusion culture of hepatocytes within galactose-derivatized biodegradable poly(lactide-co-glycolide) scaffolds prepared by gas foaming of effervescent salts. , 2002, Journal of biomedical materials research.

[193]  M. Gnecchi,et al.  Gene and cell‐based therapies for heart disease , 2004, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[194]  A. Perets,et al.  Vascular endothelial growth factor-releasing scaffolds enhance vascularization and engraftment of hepatocytes transplanted on liver lobes. , 2005, Tissue engineering.

[195]  Y. Oh,et al.  In situ gelling and mucoadhesive polymer vehicles for controlled intranasal delivery of plasmid DNA. , 2002, Journal of biomedical materials research.

[196]  E. Edelman,et al.  Perivascular graft heparin delivery using biodegradable polymer wraps. , 2000, Biomaterials.

[197]  Brian H Annex,et al.  The VIVA Trial Vascular Endothelial Growth Factor in Ischemia for Vascular Angiogenesis , 2003 .

[198]  D Breitig,et al.  Adsorption and release properties of growth factors from biodegradable implants. , 2002, Journal of biomedical materials research.

[199]  J. West,et al.  Modification of polyurethaneurea with PEG and YIGSR peptide to enhance endothelialization without platelet adhesion. , 2005, Journal of biomedical materials research. Part B, Applied biomaterials.

[200]  T. Park,et al.  Surface immobilization of galactose onto aliphatic biodegradable polymers for hepatocyte culture. , 2002, Biotechnology and bioengineering.

[201]  D. Putnam,et al.  Poly(lactic acid)-poly(ethylene glycol) nanoparticles as new carriers for the delivery of plasmid DNA. , 2001, Journal of controlled release : official journal of the Controlled Release Society.

[202]  Wenjin Guo,et al.  Efficient gene transfer using reversibly cross-linked low molecular weight polyethylenimine. , 2001, Bioconjugate chemistry.

[203]  Fotios Papadimitrakopoulos,et al.  Controlled release of dexamethasone from PLGA microspheres embedded within polyacid-containing PVA hydrogels , 2005, The AAPS Journal.

[204]  Richard T. Lee,et al.  Local myocardial insulin-like growth factor 1 (IGF-1) delivery with biotinylated peptide nanofibers improves cell therapy for myocardial infarction. , 2006, Proceedings of the National Academy of Sciences of the United States of America.

[205]  G. H. van Lenthe,et al.  Evaluation of an in situ formed synthetic hydrogel as a biodegradable membrane for guided bone regeneration. , 2006, Clinical oral implants research.

[206]  R. Ohye,et al.  Midterm clinical result of tissue-engineered vascular autografts seeded with autologous bone marrow cells. Shinoka T, Matsumura G, Hibino N, Naito Y, Watanabe M, Konuma T, Sakamoto T, Nagatsu M, Kurosawa H (2005) J Thorac Cardiovasc Surg 129: 1330-1338: Commentary , 2005 .

[207]  A S Hoffman,et al.  Protein adsorption to poly(ethylene oxide) surfaces. , 1991, Journal of biomedical materials research.

[208]  S. Ylä-Herttuala,et al.  Biology of vascular endothelial growth factors , 2006, FEBS letters.

[209]  R Langer,et al.  Functional arteries grown in vitro. , 1999, Science.

[210]  Randall J Lee,et al.  Fibrin glue alone and skeletal myoblasts in a fibrin scaffold preserve cardiac function after myocardial infarction. , 2004, Tissue engineering.

[211]  S. Simões,et al.  Cationic liposomes for gene delivery: from biophysics to biological applications. , 2003, Current medicinal chemistry.

[212]  W. H. So,et al.  Dexamethasone delays ulcer healing by inhibition of angiogenesis in rat stomachs. , 2004, European journal of pharmacology.

[213]  J. Hughes,et al.  In Situ Gel Formulations for Gene Delivery: Release and Myotoxicity Studies , 2000, Pharmaceutical development and technology.

[214]  William R Wagner,et al.  Fabrication of biodegradable elastomeric scaffolds with sub-micron morphologies. , 2004, Journal of biomedical materials research. Part A.

[215]  D. Gospodarowicz,et al.  Heparin protects basic and acidic FGF from inactivation , 1986, Journal of cellular physiology.

[216]  David J Mooney,et al.  Locally enhanced angiogenesis promotes transplanted cell survival. , 2004, Tissue engineering.

[217]  Ernst Wagner,et al.  Overcoming the nuclear barrier: cell cycle independent nonviral gene transfer with linear polyethylenimine or electroporation. , 2002, Molecular therapy : the journal of the American Society of Gene Therapy.

[218]  J Wang,et al.  Enhanced gene expression in mouse muscle by sustained release of plasmid DNA using PPE-EA as a carrier , 2002, Gene Therapy.

[219]  David J. Mooney,et al.  Controlled growth factor release from synthetic extracellular matrices , 2000, Nature.

[220]  Indranil Nandi,et al.  Synergistic effect of PEG-400 and cyclodextrin to enhance solubility of progesterone , 2003, AAPS PharmSciTech.

[221]  T. K. Hunt,et al.  The future of recombinant growth factors in wound healing. , 1998, American journal of surgery.

[222]  A. Carpentier,et al.  Myocardial Assistance by Grafting a New Bioartificial Upgraded Myocardium (MAGNUM Clinical Trial): One Year Follow-Up , 2007, Cell transplantation.

[223]  E. Brambilla,et al.  In vivo delivery to tumors of DNA complexed with linear polyethylenimine. , 1999, Human gene therapy.

[224]  Gordana Vunjak-Novakovic,et al.  Effects of oxygen on engineered cardiac muscle. , 2002, Biotechnology and bioengineering.

[225]  A. Remuzzi,et al.  Vascular smooth muscle cells on hyaluronic acid: culture and mechanical characterization of an engineered vascular construct. , 2004, Tissue engineering.

[226]  Lakeshia J Taite,et al.  Nitric oxide-producing polyurethanes. , 2005, Biomacromolecules.

[227]  S. Rajagopalan,et al.  Sustained Vascular Endothelial Growth Factor Delivery Enhances Angiogenesis and Perfusion in Ischemic Hind Limb , 2005, Pharmaceutical Research.

[228]  Richard T. Lee,et al.  Controlled delivery of PDGF-BB for myocardial protection using injectable self-assembling peptide nanofibers. , 2005, The Journal of clinical investigation.

[229]  B. Hsiao,et al.  Development of a nanostructured DNA delivery scaffold via electrospinning of PLGA and PLA-PEG block copolymers. , 2003, Journal of controlled release : official journal of the Controlled Release Society.