Liver injury induced by clomiphene citrate: A case report and literature reviews

Clomiphene citrate is used to cause ovulation in females and to increase semen production in males. Clomiphene citrate is well tolerated in most patients and rarely induces liver injury. We report a case of liver injury which is associated with administration of clomiphene citrate in a male patient.

[1]  Yitian Zhou,et al.  Worldwide Distribution of Cytochrome P450 Alleles: A Meta‐analysis of Population‐scale Sequencing Projects , 2017, Clinical pharmacology and therapeutics.

[2]  T. Köhler,et al.  Current medical management of endocrine-related male infertility , 2016, Asian journal of andrology.

[3]  A. Presson,et al.  The safety and efficacy of clomiphene citrate in hypoandrogenic and subfertile men , 2015, International Journal of Impotence Research.

[4]  J. Xing,et al.  Genetic polymorphisms of CYP2D6*10 and the effectiveness of combined tamoxifen citrate and testosterone undecanoate treatment in infertile men with idiopathic oligozoospermia , 2015, Journal of Zhejiang University-SCIENCE B.

[5]  P. Sinha,et al.  Could clomiphene kindle acute manic episode in a male patient? A case report. , 2014, General hospital psychiatry.

[6]  J. Mulhall,et al.  Clomiphene citrate is safe and effective for long‐term management of hypogonadism , 2012, BJU international.

[7]  R. Hart,et al.  Status of clomiphene citrate and metformin for infertility in PCOS , 2012, Trends in Endocrinology & Metabolism.

[8]  M. Averbeck,et al.  Twenty-five milligrams of clomiphene citrate presents positive effect on treatment of male testosterone deficiency - a prospective study. , 2012, International braz j urol : official journal of the Brazilian Society of Urology.

[9]  T. Kruger,et al.  Association between Clomiphene Citrate and Visual Disturbances with Special Emphasis on Central Retinal Vein Occlusion: A Review , 2010, Gynecologic and Obstetric Investigation.

[10]  H. Ghanem,et al.  Combination clomiphene citrate and antioxidant therapy for idiopathic male infertility: a randomized controlled trial. , 2010, Fertility and sterility.

[11]  Magnus Ingelman-Sundberg,et al.  The Human Cytochrome P450 (CYP) Allele Nomenclature website: a peer-reviewed database of CYP variants and their associated effects , 2010, Human Genomics.

[12]  L. Levine,et al.  Clomiphene citrate and testosterone gel replacement therapy for male hypogonadism: efficacy and treatment cost. , 2010, The journal of sexual medicine.

[13]  F. Pasqualotto,et al.  Azoospermia after treatment with clomiphene citrate in patients with oligospermia. , 2008, Fertility and sterility.

[14]  A. Rostami-Hodjegan,et al.  CYP2D6 is primarily responsible for the metabolism of clomiphene. , 2008, Drug metabolism and pharmacokinetics.

[15]  Jelena Savović,et al.  Methods for Causality Assessment of Adverse Drug Reactions , 2008, Drug safety.

[16]  C. Mitchell,et al.  Transaminitis after treatment with clomiphene citrate: a case report. , 2007, The Journal of reproductive medicine.

[17]  A. Elnashar,et al.  Clomiphene citrate and dexamethazone in treatment of clomiphene citrate-resistant polycystic ovary syndrome: a prospective placebo-controlled study. , 2006, Human reproduction.

[18]  O. Chazouilleres,et al.  [Drug-induced liver injury; fourteenth updated edition of the bibliographic database of liver injuries and related drugs]. , 1999, Gastroenterologie clinique et biologique.

[19]  M. Fujishima,et al.  A RARE CASE OF HEPATIC INJURY ASSOCIATED WITH OVARIAN HYPERSTIMULATION SYNDROME , 1998, American Journal of Gastroenterology.

[20]  A. Staudach,et al.  Pregnancy after ovarian stimulation and intrauterine insemination in a woman with cavernous macrohemangioma of the liver. A case report. , 1997, The Journal of reproductive medicine.

[21]  M. Biour,et al.  Hépatotoxicité des médicaments 14e mise à jour du fichier bibliographique des atteintes hépatiques et des médicaments responsables , 1995 .

[22]  I. Benkö,et al.  Focal nodular hyperplasia of the liver after clomiphene treatment in a young boy. , 1986, Acta paediatrica Hungarica.