Characterization and modeling of direct-write fabrication of microscale polymer fibers

A new direct-write system for fabricating suspended microscale and sub-microscale polymer fibers has been developed and characterized. This system is capable of generating arrays of precisely-positioned fibers with controllable diameters in three-dimensional space. The driving mechanism behind this process harnesses the surface tension of liquid bridges to promote the controlled thinning of a macroscale polymer solution filament into the desired micro- or sub-microscale fiber. The correlation between fiber diameter and several experimental parameters including solution concentration, drawing rate, and fiber length was characterized using a series of viscous poly(methyl methacrylate) (PMMA) solutions. A dimensional analysis of the physics of the fiber drawing process was used to adapt this data into an empirical relationship describing fiber formation from a generalized polymer solution. This information was subsequently utilized to predict fiber diameter from several other non-PMMA-based polymer solutions with accuracy comparable to the intrinsic variation of the process itself, thereby eliminating the need to perform lengthy characterizations on new polymer solutions.

[1]  M. Sitti,et al.  Three-dimensional nanoscale manipulation and manufacturing using proximal probes: controlled pulling of polymer micro/nanofibers , 2004, Proceedings of the IEEE International Conference on Mechatronics, 2004. ICM '04..

[2]  M. Renardy.  A numerical study of the asymptotic evolution and breakup of Newtonian and viscoelastic jets , 1995 .

[3]  M. Kotaki,et al.  Aligned biodegradable nanofibrous structure: a potential scaffold for blood vessel engineering. , 2004, Biomaterials.

[4]  R. Cohn,et al.  Direct Drawing of Suspended Filamentary Micro- and Nanostructures from Liquid Polymers , 2004 .

[5]  Gareth H. McKinley,et al.  Using filament stretching rheometry to predict strand formation and “processability” in adhesives and other non-Newtonian fluids , 2000 .

[6]  J. Ferraris,et al.  Continuous carbon nanotube composite fibers: properties, potential applications, and problemsElectronic supplementary information (ESI) available: frontispiece figure. See http://www.rsc.org/suppdata/jm/b3/b312092a/ , 2004 .

[7]  A. Ahluwalia,et al.  Fabrication of PLGA scaffolds using soft lithography and microsyringe deposition. , 2003, Biomaterials.

[8]  D. Papageorgiou.  ON THE BREAKUP OF VISCOUS LIQUID THREADS , 1995 .

[9]  Joselito M. Razal,et al.  Super-tough carbon-nanotube fibres , 2003, Nature.

[10]  R. Cohn,et al.  Biopolymerization-driven self-assembly of nanofiber air-bridges , 2008 .

[11]  M. Sitti,et al.  Drawing suspended polymer micro-/nanofibers using glass micropipettes , 2006 .

[12]  Peter Horak,et al.  Optical microfiber coil resonator refractometric sensor: erratum. , 2007, Optics express.

[13]  Jérôme Crest.  Formation of microfibers and nanofibers by capillary-driven thinning of drying viscoelastic filaments , 2009 .

[14]  Joselito M. Razal,et al.  Super-tough carbon-nanotube fibres - These extraordinary composite fibres can be woven into electronic textiles. , 2003 .

[15]  Yoonseok Yang,et al.  The application of carbon nanotube-polymer composite as gas sensing materials , 2004, Proceedings of IEEE Sensors, 2004..

[16]  M. Sitti,et al.  3-D nano-fiber manufacturing by controlled pulling of liquid polymers using nano-probes , 2003, 2003 Third IEEE Conference on Nanotechnology, 2003. IEEE-NANO 2003..

[17]  L. Sperling.  Introduction to physical polymer science , 1986 .

[18]  W. Park,et al.  In vitro degradation behavior of electrospun polyglycolide, polylactide, and poly(lactide‐co‐glycolide) , 2005 .

[19]  Robert W. Cohn,et al.  Characterization of micromanipulator-controlled dry spinning of micro- and sub-microscale polymer fibers , 2006 .

[20]  C. Doillon,et al.  Bioactive polymer fibers to direct endothelial cell growth in a three-dimensional environment. , 2007, Biomacromolecules.

[21]  F. T. Trouton,et al.  On the coefficient of viscous traction and its relation to that of viscosity , 1906 .

[22]  P. Dalton,et al.  Patterned melt electrospun substrates for tissue engineering , 2008, Biomedical materials.

[23]  R. Cohn,et al.  Characterization of micromanipulator controlled dry spinning of micro- and nanoscale polymer fibers , 2005, 2005 3rd IEEE/EMBS Special Topic Conference on Microtechnology in Medicine and Biology.

[24]  R. Cerbino.  Capillarity and Wetting Phenomena: Drops, Bubbles, Pearls, Waves , 2006 .

[25]  Scott M Berry,et al.  Oriented nanomaterial air bridges formed from suspended polymer-composite nanofibers. , 2007, ACS nano.

[26]  Dietmar W Hutmacher,et al.  Combining electrospun scaffolds with electrosprayed hydrogels leads to three-dimensional cellularization of hybrid constructs. , 2008, Biomacromolecules.

[27]  G. McKinley,et al.  FILAMENT-STRETCHING RHEOMETRY OF COMPLEX FLUIDS , 2002 .

[28]  J. Lewis,et al.  Microperiodic structures: Direct writing of three-dimensional webs , 2004, Nature.

[29]  G. McKinley,et al.  How to extract the Newtonian viscosity from capillary breakup measurements in a filament rheometer , 2000 .

[30]  Andrea S Gobin,et al.  Endothelial cell scaffolds generated by 3D direct writing of biodegradable polymer microfibers. , 2011, Biomaterials.

[31]  O. Basaran,et al.  Nonlinear deformation and breakup of stretching liquid bridges , 1996, Journal of Fluid Mechanics.