Mitochondrial role in cell aging

The experimental studies on the mitochondria of insect and mammalian cells are examined with a view to an analysis of intrinsic mitochondrial senescence, and its relation to the age-related changes in other cell organelles. The fine structural and biochemical data support the concept that the mitochondria of fixed postmitotic cells may be the site of intrinsic aging because of the attack by free radicals and lipid peroxides originating in the organelles as a by-product of oxygen reduction during respiration. Although the cells have numerous mechanisms for counteracting lipid peroxidation injury, there is a slippage in the antioxidant protection. Intrinsic mitochondrial aging could thus be considered as a specific manifestation of oxygen toxicity. It is proposed that free radical injury renders an increasing number of the mitochondria unable to divide, probably because of damage to the lipids of the inner membrane and to mitochondrial DNA.

[1]  B. Strehler,et al.  Loss of hybridizable ribosomal DNA from human post-mitotic tissues during aging: I. Age-dependent loss in human myocardium , 1979, Mechanisms of Ageing and Development.

[2]  Denham Harman,et al.  The Biologic Clock: The Mitochondria? , 1972, Journal of the American Geriatrics Society.

[3]  M. Tribe Some physiological studies in relation to age in the blowfly, Calliphora erythrocephala Meig , 1966 .

[4]  I. Fridovich Superoxide Radical and Superoxide Dismutase , 1972 .

[5]  D. Knook,et al.  Respiratory activities of hepatocytes isolated from rats of various ages. A brief note , 1977, Mechanisms of Ageing and Development.

[6]  A. Novikoff,et al.  Human hepatocellular pigments and lysosomes. , 1960, Journal of ultrastructure research.

[7]  H. Atlan,et al.  Natural aging and radiation-induced life shortening in Drosophila melanogaster. , 1972 .

[8]  E. Wills Effects of lipid peroxidation on membrane-bound enzymes of the endoplasmic reticulum. , 1971, The Biochemical journal.

[9]  K. D. Munkres Ageing of Neurospora Crassa. IX. Microviscosity properties of mitochondrial membranes during normal and abnormal growth and development of an inositol auxotroph , 1979, Mechanisms of Ageing and Development.

[10]  J. Miquel,et al.  Astroglial Reactions to Ionizing Radiation: with Emphasis on Glycogen Accumulation , 1965 .

[11]  M. Rockstein,et al.  Age Changes in Adenine Nucleotides in Flight Muscle of Male House Fly , 1961, Science.

[12]  P. Wilson,et al.  The effect of age on mitochondrial enzymes and respiration. , 1975, Gerontologia.

[13]  J. M. Reiner Senescence: A stochastic molecular control theory , 1978, Mechanisms of Ageing and Development.

[14]  W. O. Fenn,et al.  Oxygen poisoning and x-irradiation: a mechanism in common. , 1954, Science.

[15]  D. Knook,et al.  The viability of parenchymal liver cells isolated from young and old rats. , 1974, Mechanisms of ageing and development.

[16]  W. Pryor,et al.  Letter: A suggested mechanism for the production of malonaldehyde during the autoxidation of polyunsaturated fatty acids. Nonenzymatic production of prostaglandin endoperoxides during autoxidation. , 1975, The Journal of organic chemistry.

[17]  B. Leibovitz,et al.  Aspects of free radical reactions in biological systems: aging. , 1980, Journal of gerontology.

[18]  M. Rockstein,et al.  Duration and frequency of wing beat in the aging house fly, Musca domestica L. , 1966, The Biological bulletin.

[19]  J. Bjorksten THE CROSSLINKAGE THEORY OF AGING , 1968, Journal of the American Geriatrics Society.

[20]  H. Curtis,et al.  Tolerance of Mouse-Brain Tissue to High-Energy Deuterons , 1959, Science.

[21]  A. Tappel,et al.  Inactivation of ribonuclease and other enzymes by peroxidizing lipids and by malonaldehyde. , 1969, Biochemistry.

[22]  John E. Johnson,et al.  Fine structure of IMR-90 cells in culture as examined by scanning and transmission electron microscopy , 1979, Mechanisms of Ageing and Development.

[23]  E. Burns,et al.  Thinning of capillary walls and declining numbers of endothelial mitochondria in the cerebral cortex of the aging primate, Macaca nemestrina. , 1979, Journal of gerontology.

[24]  R. S. Sohal,et al.  Age-related changes in the fine structure and number of neurons in the brain of the housefly, Musca domestica. , 1972, Experimental gerontology.

[25]  J. M. Smith,et al.  Protein turnover in adult Drosophila. , 1970, Journal of insect physiology.

[26]  H. Atlan,et al.  Effects of low- and high-LET cyclotron-accelerated alpha-particles on longevity of Drosophila melanogaster. , 1970, International journal of radiation biology and related studies in physics, chemistry, and medicine.

[27]  A. Tappel,et al.  Synthesis and characterization of the fluorescent products derived from malonaldehyde and amino acids. , 1969, Biochemistry.

[28]  R. S. Sohal,et al.  Senescent changes in the cardiac myofiber of the house fly, Musca domestica. An electron microscopic study. , 1971, Journal of gerontology.

[29]  E. C. Weinbach,et al.  Oxidative phosphorylation in mitochondria from aged rats. , 1959, The Journal of biological chemistry.

[30]  I. Nagy,et al.  The aging of rat liver as revealed by electron microscopic morphometry—I. Basic parameters , 1975, Experimental Gerontology.

[31]  D. L. Schmucker Age-related changes in hepatic fine structure: a quantitative analysis. , 1976, Journal of gerontology.

[32]  E. C. Weinbach,et al.  Age and Oxidative Phosphorylation in Rat Liver and Brain , 1956, Nature.

[33]  M. Tribe Changes taking place in the respiratory efficiency of isolated flight muscle sarcosomes, associated with the age of the blowfly, Calliphora erythrocephala. , 1967, Comparative biochemistry and physiology.

[34]  R. Hay,et al.  Comparative ultrastructure of chick fibroblasts in vitro at early and late stages during their growth span. , 1971, Journal of Ultrastructure Research.

[35]  R. S. Sohal,et al.  Mitochondrial changes in flight muscles of normal and flightless Drosophila melanogaster with age , 1975, Journal of morphology.

[36]  B. Sacktor,et al.  Thyroid control of mitochondrial alpha-glycerolphosphate dehydrogenase in rat liver as a function of age. , 1971, Journal of gerontology.

[37]  D. E. Ashhurst,et al.  Biochemical and structural variations in the flight muscle mitochondria of ageing blowflies, Calliphora erythrocephala. , 1972, Journal of cell science.

[38]  P. Wilson,et al.  The effect of age on mitochondrial ultrastructure. , 1975, Gerontologia.

[39]  D. Philpott,et al.  Electron Microscope Studies on Aging Drosophila melanogaster III. Flight Muscle , 1970 .

[40]  J. Miquel,et al.  Effects of oxygen-nitrogen (1:1) at 760 torr on the life span and fine structure of drosophila melanogaster , 1975, Mechanisms of Ageing and Development.

[41]  J. Johnson,et al.  Spectrophotofluorometric and electron microscopic study of lipofuscin accumulation in the testis of aging mice. , 1978, Journal of gerontology.

[42]  H. Tauchi,et al.  Age changes in size and number of mitochondria of human hepatic cells. , 1968, Journal of gerontology.

[43]  W. Pryor Free Radicals in Biology , 1976 .

[44]  H. R. Massie,et al.  Loss of mitochondrial DNA with aging in Drosophila melanogaster. , 1975, Gerontologia.

[45]  B. Sacktor,et al.  Bioenergetics of mitochondria from flight muscles of aging blowflies: partial reactions of oxidation and phosphorylation. , 1975, Archives of biochemistry and biophysics.

[46]  D. Harman Aging: a theory based on free radical and radiation chemistry. , 1956, Journal of gerontology.

[47]  P. Bhatnagar,et al.  An electron microscope study of changes in mitochondria of flight muscle of ageing houseflies (Musca domestica). , 1969, Journal of insect physiology.

[48]  R. S. Sohal Mitochondrial changes in the heart of Drosophila repleta, Wollaston with age. , 1970, Experimental gerontology.

[49]  R. Young,et al.  Fluorescent pigment and pentane production by lipid peroxidation in honey bees, Apis Mellifera , 1978, Experimental Gerontology.

[50]  D. Harman,et al.  Role of free radicals in mutation, cancer, aging, and the maintenance of life. , 1962, Radiation research.

[51]  G. Herbener,et al.  A morphometric study of the density of mitochondrial cristae in heart and liver of aging mice. , 1976, Journal of gerontology.

[52]  M. Tribe,et al.  Are there major degenerative changes in the flight muscle of ageing diptera? , 1974, Experimental gerontology.

[53]  N. Shock,et al.  Age differences in the succinoxidase activity of homogenates and mitochondria from the livers and kidneys of rats. , 1960, Journal of gerontology.

[54]  B. Chance,et al.  Properties of glutathione release observed during reduction of organic hydroperoxide, demethylation of aminopyrine and oxidation of some substances in perfused rat liver, and their implications for the physiological function of catalase. , 1977, The Biochemical journal.

[55]  B Chance,et al.  The cellular production of hydrogen peroxide. , 1972, The Biochemical journal.

[56]  I. Fridovich The biology of oxygen radicals. , 1978, Science.

[57]  V. Wigglesworth,et al.  The utilization of reserve substances in Drosophila during flight. , 1949, The Journal of experimental biology.

[58]  D. Menzel Toxicity of ozone, oxygen, and radiation. , 1970, Annual review of pharmacology.

[59]  G. Baker Insect flight muscle: maturation and senescence. , 1976, Gerontology.

[60]  C. Duve,et al.  Functions of lysosomes. , 1966, Annual review of physiology.

[61]  R. S. Sohal Aging changes in insect flight muscle. , 1976, Gerontology.

[62]  R. Huemer,et al.  Mitochondrial studies in senescent mice. II. Specific activity, buoyant density, and turnover of mitochondrial DNA. , 1971, Experimental gerontology.

[63]  M. Rockstein,et al.  AGE CHANGES IN SIZE AND NUMBER OF THE GIANT MITOCHONDRIA IN THE FLIGHT MUSCLE OF THE COMMON HOUSEFLY (MUSCA DOMESTICA L.). , 1965, Journal of insect physiology.

[64]  S. Shafiq,et al.  Quantitative morphological analysis of age-related changes in flight muscle of Musca domestica L. , 1979, Journal of gerontology.

[65]  B. Strehler,et al.  Effect of age on oxidative phosphorylation in the rat. , 1968, Journal of gerontology.

[66]  K. L. Yielding,et al.  Fate during cell growth of yeast mitochondrial and nuclear DNA after photolytic attachment of the monoazide analog of ethidium. , 1979, Biochemical and biophysical research communications.

[67]  A. Vain,et al.  Age-related changes in mitochondrial function in Drosophila melanogaster , 1977, Experimental Gerontology.

[68]  R. Mcdaniel,et al.  Mitochondrial heterosis in aging Drosophila hybrids , 1979, Experimental Gerontology.

[69]  G H Herbener,et al.  A morphometric study of age-dependent changes in mitochondrial population of mouse liver and heart. , 1976, Journal of gerontology.

[70]  A. Comfort The position of aging studies. , 1974, Mechanisms of ageing and development.

[71]  R. S. Sohal,et al.  Age-related changes in the fine structure of the flight muscle in the house fly. , 1971, Experimental gerontology.

[72]  Bernard L. Strehler,et al.  Time, cells, and aging , 1962 .

[73]  L. Packer,et al.  Interactions between malondialdehyde and rat liver mitochondria. , 1970, Journal of gerontology.

[74]  R. Kohn Principles of mammalian aging , 1971 .

[75]  A. Tappel Biological antioxidant protection against lipid peroxidation damage. , 1970, The American journal of clinical nutrition.

[76]  D. Sanadi,et al.  Age-related changes in cytochrome concentration of myocardial mitochondria , 1978, Mechanisms of Ageing and Development.

[77]  H. R. Massie,et al.  Changes in superoxide dismutase activity and copper during development and ageing in the fruit fly Drosophila melanogaster , 1980, Mechanisms of Ageing and Development.

[78]  S. Taş Disulfide bonding in chromatin proteins with age and a suggested mechanism for aging and neoplasia , 1976, Experimental Gerontology.

[79]  R. Mcdonald,et al.  Roles of Staff in a Psychogeriatric Day Care Center , 1973 .

[80]  D. Hegner,et al.  Do mitochondria produce oxygen radicals in vivo? , 1978, European journal of biochemistry.

[81]  J. Miquel,et al.  Quantitative analysis of mating behavior in aging male drosophila melanogaster , 1979, Mechanisms of Ageing and Development.

[82]  V. Cristofalo,et al.  Ultrastructural changes accompanying the aging of human diploid cells in culture. , 1972, Journal of ultrastructure research.

[83]  B. Sacktor,et al.  Bioenergetic properties of mitochondria from flight muscle of aging blowflies. , 1972, Archives of biochemistry and biophysics.

[84]  C. Shearman,et al.  DNA replication by a membrane-DNA complex from rat liver mitochondria. , 1977, Archives of biochemistry and biophysics.

[85]  D. Sanadi,et al.  Evidence for increased degeneration of mitochondria in old rats. A brief note , 1978, Mechanisms of Ageing and Development.

[86]  A. Jones,et al.  Morphometric analysis of the ultrastructural changes in the liver of aging rats. , 1974, Journal of gerontology.

[87]  B Chance,et al.  The mitochondrial generation of hydrogen peroxide. General properties and effect of hyperbaric oxygen. , 1973, The Biochemical journal.

[88]  R. Friede,et al.  Age differences in the ultrastructure of axons in the pyramidal tract of the mouse. , 1971, Journal of gerontology.

[89]  B. Strehler,et al.  Loss of hybridizable ribosomal DNA from human post-mitotic tissues during aging: II. Age-dependent loss in human cerebral cortex — Hippocampal and somatosensory cortex comparison , 1979, Mechanisms of Ageing and Development.