Bioisosteric replacement of the pyrazole 5-aryl moiety of N-(piperidin-1-yl)-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide (SR141716A). A novel series of alkynylthiophenes as potent and selective cannabinoid-1 receptor antagonists.
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Y. Chao | Jen‐Shin Song | Kak‐Shan Shia | M. Hung | Hua-Hao Chiu | C. Kuo | Chien-Huang Wu | C. Chu | Chun-Ping Chang | Shi-Liang Tseng | Wan-Ling Chung | Y. Tung | Chia-Liang Tai | Wan-Ping Hsieh | Yinchiu Lin