Pertactin-Negative and Filamentous Hemagglutinin-Negative Bordetella pertussis, Australia, 2013–2017

During the 2008–2012 pertussis epidemic in Australia, pertactin (Prn)–negative Bordetella pertussis emerged. We analyzed 78 isolates from the 2013–2017 epidemic and documented continued expansion of Prn-negative ptxP3 B. pertussis strains. We also detected a filamentous hemagglutinin-negative and Prn-negative B. pertussis isolate.

[1]  M. Tondella,et al.  Complete Genome Sequences of Bordetella pertussis Isolates with Novel Pertactin-Deficient Deletions , 2017, Genome Announcements.

[2]  Y. Arakawa,et al.  Significant Decrease in Pertactin-Deficient Bordetella pertussis Isolates, Japan , 2017, Emerging infectious diseases.

[3]  V. Sintchenko,et al.  Characterisation of the Bordetella pertussis secretome under different media. , 2017, Journal of proteomics.

[4]  Lori Rowe,et al.  The History of Bordetella pertussis Genome Evolution Includes Structural Rearrangement , 2017, Journal of bacteriology.

[5]  V. Sintchenko,et al.  Genomic dissection of Australian Bordetella pertussis isolates from the 2008-2012 epidemic. , 2016, The Journal of infection.

[6]  M. Quail,et al.  Global Population Structure and Evolution of Bordetella pertussis and Their Relationship with Vaccination , 2014, mBio.

[7]  V. Sintchenko,et al.  Rapid Increase in Pertactin-deficient Bordetella pertussis Isolates, Australia , 2014, Emerging infectious diseases.

[8]  M. Tondella,et al.  Prevalence and Molecular Characterization of Pertactin-Deficient Bordetella pertussis in the United States , 2013, Clinical and Vaccine Immunology.

[9]  J. Miller,et al.  Predicting the Functional Effect of Amino Acid Substitutions and Indels , 2012, PloS one.

[10]  V. Sintchenko,et al.  Newly emerging clones of Bordetella pertussis carrying prn2 and ptxP3 alleles implicated in Australian pertussis epidemic in 2008-2010. , 2012, The Journal of infectious diseases.

[11]  Y. Arakawa,et al.  Prevalence and Genetic Characterization of Pertactin-Deficient Bordetella pertussis in Japan , 2012, PloS one.

[12]  R. George,et al.  Genotypic Variation in the Bordetella pertussis Virulence Factors Pertactin and Pertussis Toxin in Historical and Recent Clinical Isolates in the United Kingdom , 2001, Infection and Immunity.

[13]  R. Matthews,et al.  Epitope mapping the Fim2 and Fim3 proteins of Bordetella pertussis with sera from patients infected with or vaccinated against whooping cough. , 1996, FEMS immunology and medical microbiology.

[14]  V. Sintchenko,et al.  Insight into evolution of Bordetella pertussis from comparative genomic analysis: evidence of vaccine-driven selection. , 2011, Molecular biology and evolution.