Oncogenic alterations of metabolism.

[1]  D. Green,et al.  The central executioners of apoptosis: caspases or mitochondria? , 1998, Trends in cell biology.

[2]  B. Shilo,et al.  Insulin induces transcription of target genes through the hypoxia‐inducible factor HIF‐1α/ARNT , 1998, The EMBO journal.

[3]  S. Vaulont,et al.  Differential Roles of Upstream Stimulatory Factors 1 and 2 in the Transcriptional Response of Liver Genes to Glucose* , 1998, The Journal of Biological Chemistry.

[4]  P. Carmeliet,et al.  Role of HIF-1α in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis , 1998, Nature.

[5]  Jessica Lo,et al.  HIF‐1α is required for solid tumor formation and embryonic vascularization , 1998 .

[6]  I. Tannock,et al.  The contribution of lactic acid to acidification of tumours: studies of variant cells lacking lactate dehydrogenase. , 1998, British Journal of Cancer.

[7]  D. Fisher,et al.  Regulation of Proliferation-Survival Decisions during Tumor Cell Hypoxia , 1998, Molecular and Cellular Biology.

[8]  L. Neckers,et al.  Stabilization of wild-type p53 by hypoxia-inducible factor 1α , 1998, Nature.

[9]  W. Kaelin,et al.  Regulation of Hypoxia-Inducible mRNAs by the von Hippel-Lindau Tumor Suppressor Protein Requires Binding to Complexes Containing Elongins B/C and Cul2 , 1998, Molecular and Cellular Biology.

[10]  M. Gassmann,et al.  Cellular and developmental control of O2 homeostasis by hypoxia-inducible factor 1 alpha. , 1998, Genes & development.

[11]  G. Semenza,et al.  V-SRC induces expression of hypoxia-inducible factor 1 (HIF-1) and transcription of genes encoding vascular endothelial growth factor and enolase 1: involvement of HIF-1 in tumor progression. , 1997, Cancer research.

[12]  Saroj P. Mathupala,et al.  Glucose Catabolism in Cancer Cells , 1997, The Journal of Biological Chemistry.

[13]  C. Dang,et al.  Identification of putative c-Myc-responsive genes: characterization of rcl, a novel growth-related gene , 1997, Molecular and cellular biology.

[14]  R A Jungmann,et al.  c-Myc transactivation of LDH-A: implications for tumor metabolism and growth. , 1997, Proceedings of the National Academy of Sciences of the United States of America.

[15]  R. Eisenman,et al.  Myc target genes. , 1997, Trends in biochemical sciences.

[16]  Karl Brand,et al.  Aerobic glycolysis by proliferating cells: a protective strategy against reactive oxygen species 1 , 1997, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[17]  A. Halestrap,et al.  Energy Metabolism during Apoptosis , 1997, The Journal of Biological Chemistry.

[18]  Rakesh K. Jain,et al.  Interstitial pH and pO2 gradients in solid tumors in vivo: High-resolution measurements reveal a lack of correlation , 1997, Nature Medicine.

[19]  J. Gleadle,et al.  Induction of hypoxia-inducible factor-1, erythropoietin, vascular endothelial growth factor, and glucose transporter-1 by hypoxia: evidence against a regulatory role for Src kinase. , 1997, Blood.

[20]  G. Semenza,et al.  Hypoxia Response Elements in the Aldolase A, Enolase 1, and Lactate Dehydrogenase A Gene Promoters Contain Essential Binding Sites for Hypoxia-inducible Factor 1* , 1996, The Journal of Biological Chemistry.

[21]  D. Hanahan,et al.  Patterns and Emerging Mechanisms of the Angiogenic Switch during Tumorigenesis , 1996, Cell.

[22]  A. Giaccia,et al.  Oncogenic transformation and hypoxia synergistically act to modulate vascular endothelial growth factor expression. , 1996, Cancer research.

[23]  Saroj P. Mathupala,et al.  Glucose catabolism in cancer cells: amplification of the gene encoding type II hexokinase. , 1996, Cancer research.

[24]  M. Younes,et al.  Wide expression of the human erythrocyte glucose transporter Glut1 in human cancers. , 1996, Cancer research.

[25]  W. Fiers,et al.  The Oxidative Metabolism of Glutamine , 1996, The Journal of Biological Chemistry.

[26]  David E. Housman,et al.  Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours , 1996, Nature.

[27]  H. Towle Metabolic Regulation of Gene Transcription in Mammals (*) , 1995, The Journal of Biological Chemistry.

[28]  R. Gatenby,et al.  The potential role of transformation-induced metabolic changes in tumor-host interaction. , 1995, Cancer research.

[29]  B. Ebert,et al.  Hypoxic Regulation of Lactate Dehydrogenase A , 1995, The Journal of Biological Chemistry.

[30]  F. Bosch,et al.  Evidence from transgenic mice that myc regulates hepatic glycolysis , 1995, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[31]  M. Guppy,et al.  Glucose is essential for proliferation and the glycolytic enzyme induction that provokes a transition to glycolytic energy production. , 1994, The Journal of biological chemistry.

[32]  AC Tose Cell , 1993, Cell.

[33]  M. Gerretsen,et al.  A phase III randomised trial of cisplatinum, methotrextate, cisplatinum + methotrexate and cisplatinum + 5-FU in end stage squamous carcinoma of the head and neck. Liverpool Head and Neck Oncology Group. , 1990, British Journal of Cancer.

[34]  P. Sperryn,et al.  Blood. , 1989, British journal of sports medicine.

[35]  R. Sutherland Cell and environment interactions in tumor microregions: the multicell spheroid model. , 1988, Science.

[36]  E. Boyland Metabolism of Tumours , 1940, Nature.

[37]  J. Shirlaw THE METABOLISM OF TUMOURS , 1931 .