Gingipains promote RANKL-induced osteoclastogenesis through the enhancement of integrin β3 in RAW264.7 cells

[1]  M. Liang,et al.  Gingipains disrupt F‐actin and cause osteoblast apoptosis via integrin &bgr;1 , 2018, Journal of periodontal research.

[2]  Fuping Zhang,et al.  Signal‐Regulated Protein Kinases/Protein Kinase B‐p53‐BH3–Interacting Domain Death Agonist Pathway Regulates Gingipain‐Induced Apoptosis in Osteoblasts , 2017, Journal of periodontology.

[3]  S. Batra,et al.  FAK and paxillin, two potential targets in pancreatic cancer , 2016, Oncotarget.

[4]  E. Bak,et al.  Periodontitis mainly increases osteoclast formation via enhancing the differentiation of quiescent osteoclast precursors into osteoclasts. , 2015, Journal of periodontal research.

[5]  K. Mishima,et al.  Porphyromonas gingivalis-derived Lysine Gingipain Enhances Osteoclast Differentiation Induced by Tumor Necrosis Factor-α and Interleukin-1β but Suppresses That by Interleukin-17A , 2014, The Journal of Biological Chemistry.

[6]  A. Blangy,et al.  Podosome organization drives osteoclast-mediated bone resorption , 2014, Cell adhesion & migration.

[7]  B. Boyce.  Advances in the Regulation of Osteoclasts and Osteoclast Functions , 2013, Journal of dental research.

[8]  A. Johansson,et al.  Effects of Porphyromonas gingivalis surface-associated material on osteoclast formation , 2013, Odontology.

[9]  E. Botchwey,et al.  Regulation of osteoclast structure and function by FAK family kinases , 2012, Journal of leukocyte biology.

[10]  A. Kukita,et al.  Characterization and Identification of Subpopulations of Mononuclear Preosteoclasts Induced by TNF-α in Combination with TGF-β in Rats , 2012, PloS one.

[11]  W. Crielaard,et al.  Diverse effects of Porphyromonas gingivalis on human osteoclast formation. , 2011, Microbial pathogenesis.

[12]  H. Takeuchi,et al.  Entry of Porphyromonas gingivalis Outer Membrane Vesicles into Epithelial Cells Causes Cellular Functional Impairment , 2009, Infection and Immunity.

[13]  J. Potempa,et al.  The gingipains from Porphyromonas gingivalis do not directly induce osteoclast differentiation in primary mouse bone marrow cultures. , 2009, Journal of periodontal research.

[14]  Y. Miyamoto,et al.  Lysine-specific gingipain promotes lipopolysaccharide- and active-vitamin D3-induced osteoclast differentiation by degrading osteoprotegerin. , 2009, The Biochemical journal.

[15]  L. Claes,et al.  Influence of receptor activator of nuclear factor (NF)-κB ligand (RANKL), macrophage-colony stimulating factor (M-CSF) and fetal calf serum on human osteoclast formation and activity , 2007, Journal of Molecular Histology.

[16]  K. Okuda,et al.  Arg-gingipain A DNA Vaccine Prevents Alveolar Bone Loss in Mice , 2007, Journal of dental research.

[17]  J. Potempa,et al.  Gingipains from Porphyromonas gingivalis W83 Induce Cell Adhesion Molecule Cleavage and Apoptosis in Endothelial Cells , 2005, Infection and Immunity.

[18]  D. Sheppard,et al.  Mice Lacking the Integrin β5 Subunit Have Accelerated Osteoclast Maturation and Increased Activity in the Estrogen‐Deficient State , 2004, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[19]  P. Veith,et al.  Antigens of bacteria associated with periodontitis. , 2004, Periodontology 2000.

[20]  J. Woo,et al.  The Calcineurin/Nuclear Factor of Activated T Cells Signaling Pathway Regulates Osteoclastogenesis in RAW264.7 Cells* , 2004, Journal of Biological Chemistry.

[21]  S. Hamada,et al.  Porphyromonas gingivalis Induces Receptor Activator of NF-κB Ligand Expression in Osteoblasts through the Activator Protein 1 Pathway , 2004, Infection and Immunity.

[22]  J. Potempa,et al.  The biphasic virulence activities of gingipains: activation and inactivation of host proteins. , 2003, Current protein & peptide science.

[23]  R. Rezzonico,et al.  The receptor activator of nuclear factor (NF)κB ligand (RANKL) is a new chemotactic factor for human monocytes , 2003 .

[24]  A. Zallone,et al.  Dynamic changes in the osteoclast cytoskeleton in response to growth factors and cell attachment are controlled by β3 integrin , 2003, The Journal of cell biology.

[25]  Hiroshi Takayanagi,et al.  Induction and activation of the transcription factor NFATc1 (NFAT2) integrate RANKL signaling in terminal differentiation of osteoclasts. , 2002, Developmental cell.

[26]  N. Slakeski,et al.  Immunization with the RgpA-Kgp Proteinase-Adhesin Complexes of Porphyromonas gingivalis Protects against Periodontal Bone Loss in the Rat Periodontitis Model , 2002, Infection and Immunity.

[27]  Martin A. Schwartz,et al.  Networks and crosstalk: integrin signalling spreads , 2002, Nature Cell Biology.

[28]  Sheila M. Thomas,et al.  The Adaptor Protein Paxillin Is Essential for Normal Development in the Mouse and Is a Critical Transducer of Fibronectin Signaling , 2002, Molecular and Cellular Biology.

[29]  H. Nakanishi,et al.  Arg-Gingipain Is Responsible for the Degradation of Cell Adhesion Molecules of Human Gingival Fibroblasts and Their Death Induced by Porphyromonas gingivalis , 2001, Biological chemistry.

[30]  R. Hynes,et al.  Mice lacking beta3 integrins are osteosclerotic because of dysfunctional osteoclasts. , 2000, The Journal of clinical investigation.

[31]  D. Graves,et al.  Periodontal pathogens stimulate CC-chemokine production by mononuclear and bone-derived cells. , 1999, Journal of periodontology.

[32]  S. Teitelbaum,et al.  The Integrin αvβ5 Is Expressed on Avian Osteoclast Precursors and Regulated by Retinoic Acid , 1999 .

[33]  H. Birkedal‐Hansen,et al.  Activation and Novel Processing of Matrix Metalloproteinases by a Thiol-proteinase from the Oral Anaerobe Porphyromonas gingivalis , 1997, Journal of dental research.

[34]  L. Claes,et al.  Influence of receptor activator of nuclear factor (NF)-kB ligand (RANKL), macrophage-colony stimulating factor (M-CSF) and fetal calf serum on human osteoclast formation and activity , 2007, Journal of Molecular Histology.

[35]  S. Teitelbaum,et al.  Tumor necrosis factor alpha regulates alpha(v)beta5 integrin expression by osteoclast precursors in vitro and in vivo. , 2000, Endocrinology.

[36]  Shi Wei,et al.  Tumor Necrosis Factor α Regulatesα vβ5 Integrin Expression by Osteoclast Precursors in Vitro and in Vivo1. , 2000, Endocrinology.

[37]  S. Teitelbaum,et al.  The integrin alphavbeta5 is expressed on avian osteoclast precursors and regulated by retinoic acid. , 1999, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.