Estimating brain's functional graph from the structural graph's Laplacian

The interplay between the brain’s function and structure has been of immense interest to the neuroscience and connectomics communities. In this work we develop a simple linear model relating the structural network and the functional network. We propose that the two networks are related by the structural network’s Laplacian up to a shift. The model is simple to implement and gives accurate prediction of function’s eigenvalues at the subject level and its eigenvectors at group level.

[1]  O. Sporns,et al.  Mapping the Structural Core of Human Cerebral Cortex , 2008, PLoS biology.

[2]  Lester Melie-García,et al.  Studying the human brain anatomical network via diffusion-weighted MRI and Graph Theory , 2008, NeuroImage.

[3]  Alan C. Evans,et al.  Mapping anatomical connectivity patterns of human cerebral cortex using in vivo diffusion tensor imaging tractography. , 2009, Cerebral cortex.

[4]  Catie Chang,et al.  Time–frequency dynamics of resting-state brain connectivity measured with fMRI , 2010, NeuroImage.

[5]  Scott T. Grafton,et al.  Structural foundations of resting-state and task-based functional connectivity in the human brain , 2013, Proceedings of the National Academy of Sciences.

[6]  T. Albright Direction and orientation selectivity of neurons in visual area MT of the macaque. , 1984, Journal of neurophysiology.

[7]  H. Voss,et al.  Network diffusion accurately models the relationship between structural and functional brain connectivity networks , 2014, NeuroImage.

[8]  Olaf Sporns,et al.  Symbiotic relationship between brain structure and dynamics , 2009, BMC Neuroscience.

[9]  Fan Chung,et al.  Spectral Graph Theory , 1996 .

[10]  O Sporns,et al.  Predicting human resting-state functional connectivity from structural connectivity , 2009, Proceedings of the National Academy of Sciences.

[11]  R. Kahn,et al.  Functionally linked resting‐state networks reflect the underlying structural connectivity architecture of the human brain , 2009, Human brain mapping.