Discovery of tetrahydroisoquinoline-based bivalent heterodimeric IAP antagonists.
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Shana L. Posy | R. Talbott | S. Emanuel | David K. Williams | K. Kim | R. Borzilleri | C. Chaudhry | M. Lei | Liping Zhang | Heidi L. Perez | E. Stang
[1] C. Lukacs,et al. The structure of XIAP BIR2: understanding the selectivity of the BIR domains , 2013, Acta crystallographica. Section D, Biological crystallography.
[2] Simone Fulda,et al. Targeting IAP proteins for therapeutic intervention in cancer , 2012, Nature Reviews Drug Discovery.
[3] Liu Liu,et al. Potent bivalent Smac mimetics: effect of the linker on binding to inhibitor of apoptosis proteins (IAPs) and anticancer activity. , 2011, Journal of medicinal chemistry.
[4] Tao Zhang,et al. A potent and orally active antagonist (SM-406/AT-406) of multiple inhibitor of apoptosis proteins (IAPs) in clinical development for cancer treatment. , 2011, Journal of medicinal chemistry.
[5] D. Hanahan,et al. Hallmarks of Cancer: The Next Generation , 2011, Cell.
[6] H. Fang,et al. Applications and modifications of 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid (Tic) in peptides and peptidomimetics design and discovery. , 2010, Current protein & peptide science.
[7] Ya-hong Zhang,et al. Antitumor conjugates with polyamine vectors and their molecular mechanisms , 2010, Expert opinion on drug delivery.
[8] Christoph Borner,et al. XIAP discriminates between type I and type II FAS-induced apoptosis , 2009, Nature.
[9] M. Bolognesi,et al. Rational design, synthesis and characterization of potent, non-peptidic Smac mimics/XIAP inhibitors as proapoptotic agents for cancer therapy. , 2009, Bioorganic & medicinal chemistry.
[10] B. Cravatt,et al. A suite of activity-based probes for human cytochrome P450 enzymes. , 2009, Journal of the American Chemical Society.
[11] G Melino,et al. Ordering of caspases in cells undergoing apoptosis by the intrinsic pathway , 2009, Cell Death and Differentiation.
[12] Shaomeng Wang,et al. Design, synthesis, and evaluation of potent, nonpeptidic mimetics of second mitochondria-derived activator of caspases. , 2009, Journal of medicinal chemistry.
[13] G. Salvesen,et al. The mechanism of peptide-binding specificity of IAP BIR domains , 2008, Cell Death and Differentiation.
[14] Yigong Shi,et al. Structure-activity based study of the Smac-binding pocket within the BIR3 domain of XIAP. , 2007, Bioorganic & medicinal chemistry.
[15] Junguk Park,et al. Determination of the sequence specificity of XIAP BIR domains by screening a combinatorial peptide library. , 2006, Biochemistry.
[16] G. Salvesen,et al. Human inhibitor of apoptosis proteins: why XIAP is the black sheep of the family , 2006, EMBO reports.
[17] G. Salvesen,et al. The Human Anti-apoptotic Proteins cIAP1 and cIAP2 Bind but Do Not Inhibit Caspases* , 2006, Journal of Biological Chemistry.
[18] Saul H Rosenberg,et al. Discovery of potent antagonists of the antiapoptotic protein XIAP for the treatment of cancer. , 2004, Journal of medicinal chemistry.
[19] P. Schultz,et al. Development and characterization of nonpeptidic small molecule inhibitors of the XIAP/caspase-3 interaction. , 2003, Chemistry & biology.
[20] Takashi Tsuruo,et al. Predominant suppression of apoptosome by inhibitor of apoptosis protein in non-small cell lung cancer H460 cells: therapeutic effect of a novel polyarginine-conjugated Smac peptide. , 2003, Cancer research.
[21] Yigong Shi,et al. Molecular targeting of inhibitor of apoptosis proteins based on small molecule mimics of natural binding partners. , 2002, Biochemistry.
[22] G. Salvesen,et al. IAP proteins: blocking the road to death's door , 2002, Nature reviews. Molecular cell biology.
[23] Stephen F. Betz,et al. Structural basis for binding of Smac/DIABLO to the XIAP BIR3 domain , 2000, Nature.
[24] Xiaodong Wang,et al. Smac, a Mitochondrial Protein that Promotes Cytochrome c–Dependent Caspase Activation by Eliminating IAP Inhibition , 2000, Cell.
[25] Robert L Moritz,et al. Identification of DIABLO, a Mammalian Protein that Promotes Apoptosis by Binding to and Antagonizing IAP Proteins , 2000, Cell.
[26] Stephen W. Fesik,et al. NMR structure and mutagenesis of the inhibitor-of-apoptosis protein XIAP , 1999, Nature.
[27] J C Reed,et al. IAP family proteins--suppressors of apoptosis. , 1999, Genes & development.
[28] I. S. Blagbrough,et al. PRACTICAL SYNTHESIS OF UNSYMMETRICAL POLYAMINE AMIDES , 1998 .
[29] H. Steller. Mechanisms and genes of cellular suicide , 1995, Science.
[30] K. Kim,et al. Improved method for the preparation of guanidines , 1993 .
[31] James Lin,et al. Preparation of N,N'-bis-tert-Butoxycarbonylthiourea , 1993 .
[32] T. Tsuruo,et al. Overcoming of vincristine resistance in P388 leukemia in vivo and in vitro through enhanced cytotoxicity of vincristine and vinblastine by verapamil. , 1981, Cancer research.