A State-of-the-Art Review of Mixing in Microfluidic Mixers

Microreaction technology is one of the most innovative and rapid developing fields in chemical engineering, synthesis and process technology. Many expectations toward enhanced product selectivity, yield and purity, improved safety, and access to new products and processes are directed to the microreaction technology. Microfluidic mixer is the most important component in microfluidic devices. Based on various principles, active and passive micromixers have been designed and investigated. This review is focused on the recent developments in microfluidic mixers. An overview of the flow phenomena and mixing characteristics in active and passive micromixers is presented, including the types of physical phenomena and their utilization in micromixers. Due to the simple fabrication technology and the easy implementation in a complex microfluidic system, T-micromixer is highlighted as an example to illustrate the effect of design and operating parameters on mixing efficiency and fluid flow inside microfluidic mixers.

[1]  Jung Kyung Kim,et al.  Rapid three-dimensional passive rotation micromixer using the breakup process , 2004 .

[2]  Haim H. Bau,et al.  The Kinematics of Bend-Induced Mixing in Micro-Conduits , 2003 .

[3]  Dusan Boskovic,et al.  Novel multifunctional microreaction unit for chemical engineering , 2004 .

[4]  Nam-Trung Nguyen,et al.  Micromixers?a review , 2005 .

[5]  Juan G. Santiago,et al.  Convective instability of electrokinetic flows in a cross-shaped microchannel , 2006, Journal of Fluid Mechanics.

[6]  Nam-Trung Nguyen,et al.  Nonlinear diffusive mixing in microchannels: theory and experiments , 2004 .

[7]  Dongqing Li,et al.  Flow characteristics of water in microtubes , 1999 .

[8]  Mona E. Zaghloul,et al.  Evaluation of viscous dissipation in liquid flow in microchannels , 2003 .

[9]  J. Rossier,et al.  UV Laser Machined Polymer Substrates for the Development of Microdiagnostic Systems. , 1997, Analytical chemistry.

[10]  Jerzy Bałdyga,et al.  Turbulent Mixing and Chemical Reactions , 1999 .

[11]  Darryl Y Sasaki,et al.  Poly(dimethylsiloxane) thin films as biocompatible coatings for microfluidic devices: cell culture and flow studies with glial cells. , 2005, Journal of biomedical materials research. Part A.

[12]  N. Aubry,et al.  Electroosmotic mixing in microchannels. , 2004, Lab on a chip.

[13]  Klaus Drese,et al.  Optimization of interdigital micromixers via analytical modeling—exemplified with the SuperFocus mixer , 2004 .

[14]  Tatsuro Endo,et al.  On-chip micro-flow polystyrene bead-based immunoassay for quantitative detection of tacrolimus (FK506). , 2004, Analytical biochemistry.

[15]  Mingliang Ye,et al.  CE-microreactor-CE-MS/MS for protein analysis. , 2007, Analytical chemistry.

[16]  I. Mezić,et al.  Chaotic Mixer for Microchannels , 2002, Science.

[17]  Shinji Hasebe,et al.  Mixing in microreactors: effectiveness of lamination segments as a form of feed on product distribution for multiple reactions , 2004 .

[18]  Hengzi Wang,et al.  Optimizing layout of obstacles for enhanced mixing in microchannels , 2002 .

[19]  L. Locascio,et al.  Measurement of electroosmotic flow in plastic imprinted microfluid devices and the effect of protein adsorption on flow rate. , 1999, Journal of chromatography. A.

[20]  V Hessel,et al.  An optimised split-and-recombine micro-mixer with uniform chaotic mixing. , 2004, Lab on a chip.

[21]  D. Beebe,et al.  Principles of surface-directed liquid flow in microfluidic channels. , 2002, Analytical chemistry.

[22]  Nadine Aubry,et al.  Effects of microchannel geometry on pulsed flow mixing , 2006 .

[23]  Armand Ajdari,et al.  Patterning flows using grooved surfaces. , 2002, Analytical chemistry.

[24]  Tatsuo Ushijima,et al.  New methods for increasing productivity by using microreactors of planar pumping and alternating pumping types , 2004 .

[25]  Slobodan Panić,et al.  Experimental approaches to a better understanding of mixing performance of microfluidic devices , 2004 .

[26]  Syun-Ru Yeh,et al.  Ultrafast microfluidic mixer and freeze-quenching device. , 2003, Analytical chemistry.

[27]  Yolanda Y. Davidson,et al.  Surface modification of poly(methyl methacrylate) used in the fabrication of microanalytical devices. , 2000, Analytical chemistry.

[28]  Norbert Kockmann,et al.  Liquid Mixing in Static Micro Mixers With Various Cross Sections , 2003 .

[29]  Steffen Hardt,et al.  Laminar mixing in different interdigital micromixers: II. Numerical simulations , 2003 .

[30]  S. Garimella,et al.  Investigation of heat transfer in rectangular microchannels , 2005 .

[31]  P. Tabeling,et al.  Chaotic mixing in electrokinetically and pressure driven micro flows , 2001, Technical Digest. MEMS 2001. 14th IEEE International Conference on Micro Electro Mechanical Systems (Cat. No.01CH37090).

[32]  Paul Watts,et al.  1,4-addition of enolates to alpha,beta-unsaturated ketones within a micro reactor. , 2002, Lab on a chip.

[33]  H. Bau,et al.  A minute magneto hydro dynamic (MHD) mixer , 2001 .

[34]  R. Miyake,et al.  Micro mixer with fast diffusion , 1993, [1993] Proceedings IEEE Micro Electro Mechanical Systems.

[35]  Norbert Kockmann,et al.  Convective Mixing and Its Application to Micro Reactors , 2004 .

[36]  J. Zemel,et al.  Liquid transport in micron and submicron channels , 1990 .

[37]  Dieter Bothe,et al.  Experimental and numerical investigations of T-shaped micromixers , 2003 .

[38]  Jin-Woo Choi,et al.  A novel in-plane passive microfluidic mixer with modified Tesla structures. , 2004, Lab on a chip.

[39]  Norbert Kockmann,et al.  Flow regimes and mass transfer characteristics in static micromixers , 2003, SPIE MOEMS-MEMS.

[40]  Liwei Lin,et al.  Active microfluidic mixer and gas bubble filter driven by thermal bubble micropump , 2002 .

[41]  A Bertsch,et al.  Static micromixers based on large-scale industrial mixer geometry. , 2001, Lab on a chip.

[42]  S. Ehlers,et al.  Mixing in the offstream of a microchannel system , 2000 .

[43]  Alan Mathewson,et al.  Application of magnetohydrodynamic actuation to continuous flow chemistry. , 2002, Lab on a chip.

[44]  J. Santiago,et al.  Convective and absolute electrokinetic instability with conductivity gradients , 2005, Journal of Fluid Mechanics.

[45]  V. Hessel,et al.  Micromixers—a review on passive and active mixing principles , 2005 .

[46]  F. Regnier,et al.  A picoliter-volume mixer for microfluidic analytical systems. , 2001, Analytical chemistry.

[47]  Nadine Aubry,et al.  Electro-hydrodynamic micro-fluidic mixer. , 2003, Lab on a chip.

[48]  Mona E. Zaghloul,et al.  Viscous Dissipation Effects For Liquid Flow In Microchannels , 2002 .

[49]  Göran Stemme,et al.  A fast passive and planar liquid sample micromixer. , 2004, Lab on a chip.

[50]  Ryszard Pohorecki,et al.  Turbulent micromixing in chemical reactors - a review * , 1995 .

[51]  Michael C. L. Ward,et al.  Investigation of mixing in a cross-shaped micromixer with static mixing elements for reaction kinetics studies , 2003 .

[52]  T. Bayraktar,et al.  Characterization of liquid flows in microfluidic systems , 2006 .

[53]  Sukho Park,et al.  A highly efficient 3D micromixer using soft PDMS bonding , 2006 .

[54]  C T Lim,et al.  Bead-based microfluidic immunoassays: the next generation. , 2007, Biosensors & bioelectronics.

[55]  Young-Ho Cho,et al.  Static micromixers using alternating whirls and lamination , 2005 .

[56]  Jay N. Zemel,et al.  Liquid Transport In Micron And Submicron Channels , 1989, Optics & Photonics.

[57]  Chien-Hsiung Tsai,et al.  Design of Interactively Time-Pulsed Microfluidic Mixers in Microchips using Numerical Simulation , 2007 .

[58]  Bernhard H Weigl,et al.  Microfluidic technologies in clinical diagnostics. , 2002, Clinica chimica acta; international journal of clinical chemistry.

[59]  M. Tarlov,et al.  Control of flow direction in microfluidic devices with polyelectrolyte multilayers. , 2000, Analytical chemistry.

[60]  Yu-Cheng Lin,et al.  Design of passive mixers utilizing microfluidic self-circulation in the mixing chamber. , 2004, Lab on a chip.

[61]  Robin H. Liu,et al.  Passive mixing in a three-dimensional serpentine microchannel , 2000, Journal of Microelectromechanical Systems.

[62]  Danesh K Tafti,et al.  Evaluation of microchamber geometries and surface conditions for electrokinetic driven mixing. , 2004, Analytical chemistry.

[63]  S. Haswell,et al.  The aldol reaction of silyl enol ethers within a micro reactor. , 2001, Lab on a chip.

[64]  Peter B Howell,et al.  A microfluidic mixer with grooves placed on the top and bottom of the channel. , 2005, Lab on a chip.

[65]  Yuji Murakami,et al.  Application of on-chip cell cultures for the detection of allergic response. , 2004, Biosensors & bioelectronics.

[66]  Johan Pihl,et al.  Microfluidic technologies in drug discovery. , 2005, Drug discovery today.

[67]  Che-Hsin Lin,et al.  A rapid three-dimensional vortex micromixer utilizing self-rotation effects under low Reynolds number conditions , 2005 .

[68]  James S. Horwitz,et al.  Miniature valveless ultrasonic pumps and mixers , 2000 .

[69]  J. Koo,et al.  Liquid flow in microchannels: experimental observations and computational analyses of microfluidics effects , 2003 .

[70]  Hao Li,et al.  PDMS microfludic device for optical detection of protein immunoassay using gold nanoparticles. , 2005, Lab on a chip.

[71]  K. Jensen.  Microreaction engineering * is small better? , 2001 .

[72]  Zhao Yuchao.  Characterization of micro-mixing in T-shaped micro-mixer , 2006 .

[73]  Wolfgang Ehrfeld,et al.  Characterization of Mixing in Micromixers by a Test Reaction: Single Mixing Units and Mixer Arrays , 1999 .

[74]  Gian Luca Morini,et al.  Viscous heating in liquid flows in micro-channels , 2005 .

[75]  Howard A. Stone,et al.  ENGINEERING FLOWS IN SMALL DEVICES , 2004 .

[76]  H. B. Ma and G. P. Peterson.  LAMINAR FRICTION FACTOR IN MICROSCALE DUCTS OF IRREGULAR CROSS SECTION , 1997 .

[77]  D. Hassell,et al.  Investigation of the convective motion through a staggered herringbone micromixer at low Reynolds number flow , 2006 .

[78]  A. Pisano,et al.  Characterization of a Micro-Mixing, Pumping, and Valving System , 2001 .

[79]  T. Johnson,et al.  Rapid microfluidic mixing. , 2002, Analytical chemistry.

[80]  José Carlos B. Lopes,et al.  Study of mixing and chemical reaction in RIM , 2005 .

[81]  J. Koo,et al.  Viscous dissipation effects in microtubes and microchannels , 2004 .

[82]  D. Bothe,et al.  Fluid mixing in a T-shaped micro-mixer , 2006 .

[83]  Che-Hsin Lin,et al.  Low azeotropic solvent for bonding of PMMA microfluidic devices , 2007 .

[84]  D. Beebe,et al.  Understanding microchannel culture: parameters involved in soluble factor signaling. , 2007, Lab on a chip.

[85]  Dong Sung Kim,et al.  A serpentine laminating micromixer combining splitting/recombination and advection. , 2005, Lab on a chip.

[86]  A. Evans,et al.  Improved characterization technique for micromixers , 1999 .

[87]  Albert van den Berg,et al.  A Rapid Vortex Micromixer for Studying High-Speed Chemical Reactions , 2001 .

[88]  H. Becker,et al.  Polymer microfluidic devices. , 2002, Talanta.

[89]  Jens Anders Branebjerg,et al.  Fast mixing by lamination , 1996, Proceedings of Ninth International Workshop on Micro Electromechanical Systems.

[90]  Norbert Kockmann,et al.  Numerical and experimental investigations on liquid mixing in static micromixers , 2004 .

[91]  G. Peterson,et al.  Convective heat transfer and flow friction for water flow in microchannel structures , 1996 .

[92]  A. deMello.  Control and detection of chemical reactions in microfluidic systems , 2006, Nature.

[93]  Fridolin Okkels,et al.  An example of a chaotic micromixer: the cross-channel micromixer , 2004 .

[94]  Qingxi J. Shen,et al.  Symmetrical directional cloning: An efficient method to prepare hairpin RNA interference constructs , 2004 .

[95]  Martin Gröschl,et al.  Single half-wavelength ultrasonic particle filter: predictions of the transfer matrix multilayer resonator model and experimental filtration results. , 2002, The Journal of the Acoustical Society of America.

[96]  Dongqing Li,et al.  Heat Transfer and Fluid Flow in Microchannels , 1996, Microelectromechanical Systems (MEMS).

[97]  Man Wong,et al.  Surface-chemistry technology for microfluidics , 2003 .

[98]  Jianzhong Lin,et al.  Numerical Simulation of the Scalar Mixing Characteristics in Three-dimensional Microchannels , 2005 .

[99]  Henrik Jensen,et al.  Finite element simulation of pinched pressure-driven flow injection in microchannels. , 2002, Analytical chemistry.

[100]  Zeng-Yuan Guo,et al.  Size effect on microscale single-phase flow and heat transfer , 2002 .

[101]  Chung-Yi Wu,et al.  Mixing enhancement of the passive microfluidic mixer with J-shaped baffles in the tee channel , 2007, Biomedical microdevices.

[102]  P L Gourley,et al.  Biocompatible semiconductor optoelectronics. , 2002, Journal of biomedical optics.

[103]  P. Yager,et al.  Biotechnology at low Reynolds numbers. , 1996, Biophysical journal.

[104]  S. Haswell,et al.  Kumada-Corriu reactions in a pressure-driven microflow reactor. , 2001, Lab on a chip.

[105]  Jeremy L. Steinbacher,et al.  Greener approaches to organic synthesis using microreactor technology. , 2007, Chemical reviews.

[106]  Dorian Liepmann,et al.  PLANAR LAMINAR MIXER , 2000 .

[107]  J. Josserand,et al.  Mixing processes in a zigzag microchannel: finite element simulations and optical study. , 2002, Analytical chemistry.

[108]  Asterios Gavriilidis,et al.  Mixing characteristics of T-type microfluidic mixers , 2001 .

[109]  W. E. van der Linden,et al.  Convection and diffusion in a micro-flow injection system , 1998 .

[110]  Jeremy J. Hawkes,et al.  Force field particle filter, combining ultrasound standing waves and laminar flow , 2001 .

[111]  Hiroshi Goto,et al.  Ultrasonic micromixer for microfluidic systems , 2000, Proceedings IEEE Thirteenth Annual International Conference on Micro Electro Mechanical Systems (Cat. No.00CH36308).

[112]  B. W. Webb,et al.  Characterization of frictional pressure drop for liquid flows through microchannels , 2002 .

[113]  M. Gad-el-Hak.  The Fluid Mechanics of Microdevices—The Freeman Scholar Lecture , 1999 .

[114]  A. Manz,et al.  Microstructure for efficient continuous flow mixing , 1999 .

[115]  G. Whitesides,et al.  Patterning electro-osmotic flow with patterned surface charge. , 2000, Physical review letters.

[116]  Theodore C Marentis,et al.  Ultrasonic mixing in microfluidic channels using integrated transducers. , 2004, Analytical chemistry.