The immunopathogenesis and regulation of

A variety of experimental approaches are currently being evaluated for controlling CD4 ~ T helper 1 (Th 1)-mediated autoimmune pathology. Here, Stephen Miller and William Karpus compare and contrast the efficacies of various antigen-specific regulatoo, strategies. Particular emphasis is placed on the mechanisms of peripheral immune tolerance and bow this may be used in tbe treatment and analysis of the pathologic T-cell repertoire in ataoimmune and virus-reduced demyelinating diseases.