Automated segmentation of the choroid in retinal optical coherence tomography images

The choroid is a tissue layer at the back of the eye, which can be imaged by optical coherence tomography (OCT). Choroidal thickness has been proven to be correlated to several ophthalmic diseases in several studies. In this paper we proposed a novel segmentation technique to address this challenge. This technique firstly automatically segments the inner boundary of the choroid using a two-stage fast active contour model. It secondly allows a real-time human-supervised automated segmentation on the outer boundary of the choroid. Dice similarity coefficient (DSC) was used to evaluate the agreement between manual annotation and our automated measurements on 30 images captured from patients diagnosed with diabetes. The mean DSC value is 92.7% (standard deviation 3.6%) in the range of 85.5% to 98.1%. Results show that this new technique can achieve choroid segmentation with high accuracy.

[1]  Se Woong Kang,et al.  Choroidal thickness in polypoidal choroidal vasculopathy and exudative age-related macular degeneration. , 2011, Ophthalmology.

[2]  Xavier Bresson,et al.  Fast Global Minimization of the Active Contour/Snake Model , 2007, Journal of Mathematical Imaging and Vision.

[3]  Joshua R. Ehrlich,et al.  Peripapillary choroidal thickness in glaucoma measured with optical coherence tomography. , 2011, Experimental eye research.

[4]  Tomohiro Iida,et al.  SUBFOVEAL CHOROIDAL THICKNESS IN FELLOW EYES OF PATIENTS WITH CENTRAL SEROUS CHORIORETINOPATHY , 2011, Retina.

[5]  Ghassan Hamarneh,et al.  Live-Vessel: Extending Livewire for Simultaneous Extraction of Optimal Medial and Boundary Paths in Vascular Images , 2007, MICCAI.

[6]  J. Duker,et al.  Analysis of choroidal thickness in age-related macular degeneration using spectral-domain optical coherence tomography. , 2011, American journal of ophthalmology.

[7]  Stefan Sacu,et al.  Comparison of retinal thickness measurements and segmentation performance of four different spectral and time domain OCT devices in neovascular age-related macular degeneration , 2009, British Journal of Ophthalmology.

[8]  Michael V. Boland,et al.  Choroidal thickness measured by spectral domain optical coherence tomography: factors affecting thickness in glaucoma patients. , 2011, Ophthalmology.

[9]  Xiaodong Wu,et al.  Semiautomated segmentation of the choroid in spectral-domain optical coherence tomography volume scans. , 2013, Investigative ophthalmology & visual science.

[10]  Stefano Soatto,et al.  Unsupervised multiphase segmentation: A recursive approach , 2009, Comput. Vis. Image Underst..

[11]  Paul L. Rosin,et al.  Automated choroidal segmentation of 1060 nm OCT in healthy and pathologic eyes using a statistical model , 2011, Biomedical optics express.

[12]  Boris Hermann,et al.  Mapping choroidal and retinal thickness variation in type 2 diabetes using three-dimensional 1060-nm optical coherence tomography. , 2011, Investigative ophthalmology & visual science.

[13]  K. Nishida,et al.  Evaluation of the choroidal thickness using high-penetration optical coherence tomography with long wavelength in highly myopic normal-tension glaucoma. , 2010, American journal of ophthalmology.

[14]  ANTONIN CHAMBOLLE,et al.  An Algorithm for Total Variation Minimization and Applications , 2004, Journal of Mathematical Imaging and Vision.

[15]  Edsger W. Dijkstra,et al.  A note on two problems in connexion with graphs , 1959, Numerische Mathematik.

[16]  Ke Chen,et al.  A Hierarchical Algorithm for Multiphase Texture Image Segmentation , 2012 .

[17]  H. Grossniklaus,et al.  Morphometric analysis of the choroid, Bruch's membrane, and retinal pigment epithelium in eyes with age-related macular degeneration. , 1996, Investigative ophthalmology & visual science.

[18]  M. Sonka,et al.  Automated segmentation of the choroid from clinical SD-OCT. , 2012, Investigative ophthalmology & visual science.

[19]  S. W. Kang,et al.  Choroidal thickness in both eyes of patients with unilaterally active central serous chorioretinopathy , 2011, Eye.

[20]  Josh Wallman,et al.  The multifunctional choroid , 2010, Progress in Retinal and Eye Research.

[21]  Tony F. Chan,et al.  Active contours without edges , 2001, IEEE Trans. Image Process..

[22]  Soon-Sun Kwon,et al.  COMPARISON OF CHOROIDAL THICKNESS AMONG PATIENTS WITH HEALTHY EYES, EARLY AGE-RELATED MACULOPATHY, NEOVASCULAR AGE-RELATED MACULAR DEGENERATION, CENTRAL SEROUS CHORIORETINOPATHY, AND POLYPOIDAL CHOROIDAL VASCULOPATHY , 2011, Retina.

[23]  Xiaoyan Ding,et al.  Choroidal thickness in healthy Chinese subjects. , 2011, Investigative ophthalmology & visual science.

[24]  Y. Ikuno,et al.  Choroidal thickness in healthy Japanese subjects. , 2010, Investigative ophthalmology & visual science.