Membrane thickness design of implantable bio-MEMS sensors for the in-situ monitoring of blood flow

This paper presents some ideas for the membrane thickness design of of implantable bio-micro-electro-mechanical systems (bio-MEMS) for the in situ monitoring of blood flow. The objective is to develop a smart wireless sensing unit for non-invasive early stenosis detection in heart bypass grafts. The design includes considerations of nonlinear material models, multiscale blood flows, and appropriate analyical models for data interpretation, as well as preliminary studies of the pressure and flow sensing concepts. The paper also examines the use of surface coatings for the design on biocompatibility and non-adhesion of blood platelets and constituents. The implications of the results are discussed for in vivo deployment of such sensor systems.

[1]  A. S. Dvinsky,et al.  Simulation of three-dimensional pulsatile flow through an asymmetric stenosis , 1994, Medical and Biological Engineering and Computing.

[2]  M. Deville,et al.  Pulsatile flow of non-Newtonian fluids through arterial stenoses. , 1996, Journal of biomechanics.

[3]  M D Deshpande,et al.  Steady laminar flow through modelled vascular stenoses. , 1976, Journal of biomechanics.

[4]  Toshiro Ohashi,et al.  Local elastic modulus of atherosclerotic lesions of rabbit thoracic aortas measured by pipette aspiration method. , 2002, Physiological measurement.

[5]  J. Awrejcewicz,et al.  Theory of plates and shells: new trends and applications , 2004 .

[6]  D. Ku,et al.  A nonlinear axisymmetric model with fluid-wall interactions for steady viscous flow in stenotic elastic tubes. , 1999, Journal of biomechanical engineering.

[7]  Takehisa Matsuda,et al.  Recent progress of vascular graft engineering in Japan. , 2004, Artificial organs.

[8]  N R Cholvin,et al.  Pressure Drop across Artificially Induced Stenoses in the Femoral Arteries of Dogs , 1975, Circulation research.

[9]  Steven H Frankel,et al.  Numerical modeling of pulsatile turbulent flow in stenotic vessels. , 2003, Journal of biomechanical engineering.

[10]  J. C. Misra,et al.  A non-Newtonian fluid model for blood flow through arteries under stenotic conditions. , 1993, Journal of biomechanics.

[11]  Zhigang Suo,et al.  Fatigue damage evolution in silicon films for micromechanical applications , 2003 .

[12]  William N. Sharpe,et al.  Round-Robin Tests of Modulus and Strength of Polysilicou , 1998 .

[13]  D. F. Young.  Fluid Mechanics of Arterial Stenoses , 1979 .

[14]  C G ROB,et al.  Hemodynamic effects of arterial stenosis. , 1963, Surgery.

[15]  R. Ritchie,et al.  High-cycle fatigue of single-crystal silicon thin films , 2001 .

[16]  M. Deville,et al.  Finite element simulation of pulsatile flow through arterial stenosis. , 1992, Journal of biomechanics.

[17]  K Hayashi,et al.  Tensile property of atheromatous plaque and an analysis of stress in atherosclerotic wall. , 1997, Journal of biomechanics.

[18]  B. S. Gow,et al.  Changes in the microindentation properties of aortic intimal surface during cholesterol feeding of rabbits. , 1983, Atherosclerosis.

[19]  D. J. Patel,et al.  Static Anisotropic Elastic Properties of the Aorta in Living Dogs , 1969, Circulation research.

[20]  M. Madou.  Fundamentals of microfabrication : the science of miniaturization , 2002 .

[21]  C. Roy,et al.  The Elastic Properties of the Arterial Wall , 1881, The Journal of physiology.

[22]  D. F. Young,et al.  Flow characteristics in models of arterial stenoses. I. Steady flow. , 1973, Journal of biomechanics.

[23]  Andrea Tura,et al.  Numerical simulation of flow oscillations in stenotic arterial segment , 2001, Comput. Biol. Medicine.

[24]  A. Grodzinsky,et al.  Structure‐Dependent Dynamic Mechanical Behavior of Fibrous Caps From Human Atherosclerotic Plaques , 1991, Circulation.

[25]  R. Ballarini,et al.  Fatigue Failure in Polysilicon Not Due to Simple Stress Corrosion Cracking , 2002, Science.

[26]  Marcus Textor,et al.  Titanium in Medicine : material science, surface science, engineering, biological responses and medical applications , 2001 .

[27]  J. Connally,et al.  Slow Crack Growth in Single-Crystal Silicon , 1992, Science.

[28]  J. C. Misra,et al.  Flow in arteries in the presence of stenosis. , 1986, Journal of biomechanics.

[29]  K Hayashi,et al.  Experimental approaches on measuring the mechanical properties and constitutive laws of arterial walls. , 1993, Journal of biomechanical engineering.

[30]  T. J. Mueller,et al.  Numerical Study of the Steady Axisymmetric Flow Through a Disk-Type Prosthetic Heart Valve in an Aortic-Shaped Chamber , 1979 .

[31]  Danny Bluestein,et al.  Vortex Shedding in Steady Flow Through a Model of an Arterial Stenosis and Its Relevance to Mural Platelet Deposition , 1999, Annals of Biomedical Engineering.

[32]  G. Zendehbudi,et al.  Effects of elastic property of the wall on flow characteristics through arterial stenoses. , 2003, Journal of biomechanics.

[33]  Frederick J. Schoen,et al.  Prediction of mechanical properties of human atherosclerotic tissue by high-frequency intravascular ultrasound imaging. An in vitro study. , 1992 .

[34]  D. Drikakis,et al.  Laminar-to-turbulent transition in pulsatile flow through a stenosis. , 2002, Biorheology.

[35]  S. Timoshenko,et al.  THEORY OF PLATES AND SHELLS , 1959 .

[36]  Stuart B. Brown,et al.  Subcritical crack growth in silicon MEMS , 1999 .

[37]  T. J. Mueller,et al.  Numerical Study of the Steady Axisymmetric Flow Through a Disk-Type Prosthetic Heart Valve in a Constant Diameter Chamber , 1977 .

[38]  An improved microindentation technique to measure changes in properties of arterial intima during atherogenesis. , 1983, Journal of biomechanics.

[39]  Pranav Shrotriya,et al.  Surface topography evolution and fatigue fracture in polysilicon MEMS structures , 2003 .

[40]  L. Gibson,et al.  Static circumferential tangential modulus of human atherosclerotic tissue. , 1994, Journal of biomechanics.

[41]  Salunke Nv,et al.  Biomechanics of atherosclerotic plaque. , 1997 .

[42]  Buddy D. Ratner,et al.  Biomaterials Science: An Introduction to Materials in Medicine , 1996 .

[43]  R Guidoin,et al.  Low Reynolds number turbulence modeling of blood flow in arterial stenoses. , 1998, Biorheology.

[44]  Y. Fung,et al.  Biomechanics: Mechanical Properties of Living Tissues , 1981 .