Targeting of the protein interaction site between FAK and IGF-1R.
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A. Magis | V. Golubovskaya | W. Cance | S. Hochwald | D. Ostrov | Steven N Hochwald | D. Ucar | William G Cance | Vita Golubovskaya | Andrew Magis | David Ostrov | Donghang Zheng | Elena Kurenova | Deniz Ucar | Donghang Zheng | E. Kurenova | Deniz A. Ucar
[1] V. Golubovskaya,et al. FAK and IGF-IR interact to provide survival signals in human pancreatic adenocarcinoma cells. , 2008, Carcinogenesis.
[2] M. Iacocca,et al. Immunohistochemical analyses of focal adhesion kinase expression in benign and malignant human breast and colon tissues: correlation with preinvasive and invasive phenotypes. , 2000, Clinical cancer research : an official journal of the American Association for Cancer Research.
[3] H. Werner,et al. Similarities and differences between insulin and IGF-I: Structures, receptors, and signalling pathways , 2008, Archives of Physiology and Biochemistry.
[4] I. McCutcheon,et al. The effects of insulin-like growth factors on tumorigenesis and neoplastic growth. , 2000, Endocrine reviews.
[5] C. Livasy,et al. Overexpression of focal adhesion kinase in primary colorectal carcinomas and colorectal liver metastases: immunohistochemistry and real-time PCR analyses. , 2003, Clinical cancer research : an official journal of the American Association for Cancer Research.
[6] B. van de Water,et al. Focal adhesion kinase: a potential target in cancer therapy. , 2007, Biochemical pharmacology.
[7] Anil K Sood,et al. Biological significance of focal adhesion kinase in ovarian cancer: role in migration and invasion. , 2004, The American journal of pathology.
[8] J. Parsons,et al. Focal adhesion kinase: the first ten years , 2003, Journal of Cell Science.
[9] Bob van de Water,et al. Focal adhesion kinase: a potential target in cancer therapy. , 2007, Biochemical pharmacology.
[10] M. Schaller,et al. FAK regulates biological processes important for the pathogenesis of cancer , 2003, Cancer and Metastasis Reviews.
[11] D. Schlaepfer,et al. Control of motile and invasive cell phenotypes by focal adhesion kinase. , 2004, Biochimica et biophysica acta.
[12] L. Kornberg,et al. Focal adhesion kinase expression in oral cancers , 1998, Head & neck.
[13] P. Nelson,et al. An Antibody Targeting the Type I Insulin-like Growth Factor Receptor Enhances the Castration-Induced Response in Androgen-Dependent Prostate Cancer , 2007, Clinical Cancer Research.
[14] D. Shalloway,et al. Regulation of focal adhesion-associated protein tyrosine kinase by both cellular adhesion and oncogenic transformation , 1992, Nature.
[15] S. Hanks,et al. Tyrosine phosphorylation of focal adhesion kinase at sites in the catalytic domain regulates kinase activity: a role for Src family kinases , 1995, Molecular and cellular biology.
[16] B. Geiger,et al. Transmembrane crosstalk between the extracellular matrix--cytoskeleton crosstalk. , 2001, Nature reviews. Molecular cell biology.
[17] P. Karplus,et al. Structure of the ERM Protein Moesin Reveals the FERM Domain Fold Masked by an Extended Actin Binding Tail Domain , 2000, Cell.
[18] F. Peruzzi,et al. The IGF‐1 receptor in cancer biology , 2003, International journal of cancer.
[19] C. Damsky,et al. FAK integrates growth-factor and integrin signals to promote cell migration , 2000, Nature Cell Biology.
[20] David Cunningham,et al. Insulin-like growth factor 1 receptor targeted therapeutics: novel compounds and novel treatment strategies for cancer medicine. , 2009, Recent patents on anti-cancer drug discovery.
[21] J. Parsons,et al. Focal adhesion kinase and associated proteins. , 1994, Current opinion in cell biology.
[22] C. Livasy,et al. Focal Adhesion Kinase Overexpression in Endometrial Neoplasia , 2004, Applied immunohistochemistry & molecular morphology : AIMM.
[23] Neil O. Carragher,et al. The role of focal-adhesion kinase in cancer — a new therapeutic opportunity , 2005, Nature Reviews Cancer.
[24] Beat Imhof,et al. The inner lives of focal adhesions. , 2002, Trends in cell biology.
[25] S. Brewster,et al. Silencing of the IGF1R gene enhances sensitivity to DNA-damaging agents in both PTEN wild-type and mutant human prostate cancer , 2005, Cancer Gene Therapy.
[26] J. Ruidavets,et al. Expression of focal adhesion kinase in acute myeloid leukemia is associated with enhanced blast migration, increased cellularity, and poor prognosis. , 2004, Cancer research.
[27] Xinming Cai,et al. Structural Basis for the Autoinhibition of Focal Adhesion Kinase , 2007, Cell.
[28] Kenneth M. Yamada,et al. Cell interactions with three-dimensional matrices. , 2002, Current opinion in cell biology.
[29] Kenneth M. Yamada,et al. Transmembrane crosstalk between the extracellular matrix and the cytoskeleton , 2001, Nature Reviews Molecular Cell Biology.
[30] L. T. Ten Eyck,et al. Protein docking using continuum electrostatics and geometric fit. , 2001, Protein engineering.
[31] J. Guan,et al. Regulation of Focal Adhesion Kinase by Its Amino-Terminal Domain through an Autoinhibitory Interaction , 2003, Molecular and Cellular Biology.
[32] H. Werner,et al. Similarities and differences between insulin and IGF-I: Structures, receptors, and signalling pathways , 2008, Archives of physiology and biochemistry.
[33] S. Hanks,et al. Focal adhesion kinase signaling activities and their implications in the control of cell survival and motility. , 2003, Frontiers in bioscience : a journal and virtual library.
[34] S. Stirdivant,et al. Crystal Structure of the Apo, Unactivated Insulin-like Growth Factor-1 Receptor Kinase , 2002, The Journal of Biological Chemistry.
[35] L. Kornberg. Focal adhesion kinase and its potential involvement in tumor invasion and metastasis , 1998, Head & neck.
[36] L. Bégin,et al. Focal adhesion kinase (pp125FAK) expression, activation and association with paxillin and p50CSK in human metastatic prostate carcinoma , 1996, International journal of cancer.
[37] W. Cance,et al. Overexpression of the focal adhesion kinase (p125FAK) in invasive human tumors. , 1995, Cancer research.
[38] T. Rohan,et al. Role of the insulin-like growth factor family in cancer development and progression. , 2000, Journal of the National Cancer Institute.
[39] A. Magis,et al. A small molecule inhibitor, 1,2,4,5-benzenetetraamine tetrahydrochloride, targeting the y397 site of focal adhesion kinase decreases tumor growth. , 2008, Journal of medicinal chemistry.
[40] J. Parsons,et al. pp125FAK a structurally distinctive protein-tyrosine kinase associated with focal adhesions. , 1992, Proceedings of the National Academy of Sciences of the United States of America.
[41] R. Baserga,et al. IGF-I receptor signalling in transformation and differentiation , 2001, Molecular pathology : MP.
[42] M. Eck,et al. Crystal Structure of the FERM Domain of Focal Adhesion Kinase* , 2006, Journal of Biological Chemistry.
[43] Xiaping He,et al. Overexpression of focal adhesion kinase, a protein tyrosine kinase, in ovarian carcinoma , 1999, Cancer.
[44] Roberto D Lins,et al. Prediction of HIV-1 integrase/viral DNA interactions in the catalytic domain by fast molecular docking. , 2004, Journal of medicinal chemistry.
[45] S. Hanks,et al. Signaling through focal adhesion kinase , 1997, BioEssays : news and reviews in molecular, cellular and developmental biology.