Reexamination of tetrodotoxin production by bacteria

Vibrio alginolyticus has been reported as a good producer of tetrodotoxin (TTX), but the toxin extracted from this bacterium did not react to the monoclonal antibody against TTX. Surprisingly, chromatographic analyses detected high TTX peaks for polypeptone and yeast extracts used as medium materials, which were, as expected, all negative by the mouse bioassay. These results may require us to revise the bacterial production of TTX.

[1]  K. Matsumura.  A monoclonal antibody against tetrodotoxin that reacts to the active group for the toxicity. , 1995, European journal of pharmacology.

[2]  T. Yasumoto,et al.  Taxonomy of four marine bacterial strains that produce tetrodotoxin. , 1990, International journal of systematic bacteriology.

[3]  K. Kogure,et al.  Identification of Deep-Sea-Sediment Bacteria Which Produce Tetrodotoxin , 1990, Applied and environmental microbiology.

[4]  T. Noguchi,et al.  Tetrodotoxin, with Special Reference to its Origin and the Mechanism Involved in Toxification of Puffers , 1989 .

[5]  T. Noguchi,et al.  Tetrodotoxin-producing bacteria from the horseshoe crab Carcinoscorpius rotundicauda. , 1988 .

[6]  H. Sugita,et al.  Vibrio alginolyticus, a tetrodotoxin-producing bacterium, in the intestines of the fish Fugu vermicularis vermicularis , 1987 .

[7]  T. Noguchi,et al.  Marine bacteria which produce tetrodotoxin , 1987, Applied and environmental microbiology.

[8]  憲永 三輪,et al.  トゲモミジガイ(ヒトデ)から分離したVibrio alginolyticusによるテトロドトキシンの産生 , 1987 .

[9]  T. Noguchi,et al.  Analysis of paralytic shellfish poison and tetrodotoxin by ion-pairing high performance liquid chromatography. , 1987 .

[10]  H. Naoki,et al.  Production of tetrodotoxin and its derivatives by Pseudomonas sp. isolated from the skin of a pufferfish. , 1987, Toxicon : official journal of the International Society on Toxinology.

[11]  Y. Kotaki,et al.  Bacterial Production of Tetrodotoxin and Anhydrotetrodotoxin , 1986 .

[12]  H. Sugita,et al.  Occurrence of tetrodotoxin and anhydrotetrodotoxin in Vibrio sp. isolated from the intestines of a xanthid crab, Atergatis floridus. , 1986, Journal of biochemistry.

[13]  T. Yasumoto,et al.  Fluorometric Determination of Tetrodotoxin by High Performance Liquid Chromatography , 1985 .

[14]  T. Noguchi,et al.  Occurrence of Tetrodotoxin in a Trumpet Shell, “Boshubora” Charonia sauliae , 1981 .

[15]  Kao Cy.  TETRODOTOXIN, SAXITOXIN AND THEIR SIGNIFICANCE IN THE STUDY OF EXCITATION PHENOMENA , 1966 .

[16]  C. Y. Kao.  Tetrodotoxin, saxitoxin and their significance in the study of excitation phenomena. , 1966, Pharmacological reviews.