Brain targeted rivastigmine mucoadhesive thermosensitive In situ gel: Optimization, in vitro evaluation, radiolabeling, in vivo pharmacokinetics and biodistribution
暂无分享,去创建一个
[1] M. Rao,et al. Thermoreversible mucoadhesive in situ nasal gel for treatment of Parkinson’s disease , 2017, Drug development and industrial pharmacy.
[2] T. Sakr,et al. In silico study and biological evaluation of 99mTc-tricabonyl oxiracetam as a selective imaging probe for AMPA receptors , 2017, Journal of Radioanalytical and Nuclear Chemistry.
[3] V. Pokharkar,et al. Quetiapine Nanoemulsion for Intranasal Drug Delivery: Evaluation of Brain-Targeting Efficiency , 2017, AAPS PharmSciTech.
[4] M. Khedr,et al. Platelet-12 lipoxygenase targeting via a newly synthesized curcumin derivative radiolabeled with technetium-99m , 2016, Chemistry Central Journal.
[5] A. A. El-Bary,et al. CHITOSAN MUCOADHESIVE BUCCAL FILMS: EFFECT OF DIFFERENT CASTING SOLVENTS ON THEIR PHYSICOCHEMICAL PROPERTIES , 2016 .
[6] Jouni Hirvonen,et al. Stabilizing Agents for Drug Nanocrystals: Effect on Bioavailability , 2016, Pharmaceutics.
[7] T. Phaechamud,et al. Drug release behavior of polymeric matrix filled in capsule , 2015, Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society.
[8] K. Abouzid,et al. Radioiodination and biological evaluation of Cladribine as potential agent for tumor imaging and therapy , 2015 .
[9] R. Murthy,et al. Effect of Different Polymer Concentration on Drug Release Rate and Physicochemical Properties of Mucoadhesive Gastroretentive Tablets , 2015, Indian journal of pharmaceutical sciences.
[10] M. Khedr,et al. (99m)Tc-amitrole as a novel selective imaging probe for solid tumor: In silico and preclinical pharmacological study. , 2015, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.
[11] S. Nazzal,et al. Thermoresponsive fluconazole gels for topical delivery: rheological and mechanical properties, in vitro drug release and anti-fungal efficacy , 2015, Pharmaceutical development and technology.
[12] S. Baboota,et al. Pharmacoscintigraphic evaluation of potential of lipid nanocarriers for nose-to-brain delivery of antidepressant drug. , 2014, International journal of pharmaceutics.
[13] M. A. Motaleb,et al. Radioiodinated acebutolol as a new highly selective radiotracer for myocardial perfusion imaging. , 2014, Journal of labelled compounds & radiopharmaceuticals.
[14] Z. Zuo,et al. Development, characterization and application of in situ gel systems for intranasal delivery of tacrine. , 2014, International journal of pharmaceutics.
[15] M. A. Motaleb,et al. Formulation and preclinical evaluation of 99mTc–gemcitabine as a novel radiopharmaceutical for solid tumor imaging , 2014, Journal of Radioanalytical and Nuclear Chemistry.
[16] G. Abdelbary,et al. Silver sulfadiazine based cubosome hydrogels for topical treatment of burns: development and in vitro/in vivo characterization. , 2014, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.
[17] P. Chaudhari,et al. Development of in situ gel for nasal delivery: design, optimization, in vitro and in vivo evaluation , 2014, Drug delivery.
[18] M. A. Motaleb,et al. Synthesis, radioiodination and in vivo evaluation of ethyl 1,4-dihydro-7-iodo-4-oxoquinoline-3-carboxylate as a potential pulmonary perfusion scintigraphic radiopharmaceutical , 2014, Journal of Radioanalytical and Nuclear Chemistry.
[19] A. Gharbi,et al. Rheological Properties and Reverse Micelles Conditions of PEO-PPO-PEO Pluronic F68: Effects of Temperature and Solvent Mixtures , 2013 .
[20] G. Awad,et al. Biodistribution of 99mTc-sunitinib as a potential radiotracer for tumor hypoxia imaging. , 2013, Journal of labelled compounds & radiopharmaceuticals.
[21] S. Pund,et al. Ex vivo permeation characteristics of venlafaxine through sheep nasal mucosa. , 2013, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.
[22] Gabriela G Pereira,et al. Formulation and characterization of poloxamer 407®: thermoreversible gel containing polymeric microparticles and hyaluronic acid , 2013 .
[23] M. E. Moustapha,et al. 99mTc-nebivolol as a novel heart imaging radiopharmaceutical for myocardial infarction assessment , 2013, Journal of Radioanalytical and Nuclear Chemistry.
[24] A. Avachat,et al. Thermoreversible Nasal In situ Gel of Venlafaxine Hydrochloride: Formulation, Characterization, and Pharmacodynamic Evaluation , 2012, AAPS PharmSciTech.
[25] Sanjeev Shandilya,et al. Identification, characterization and quantification of new impurities by LC-ESI/MS/MS and LC-UV methods in rivastigmine tartrate active pharmaceutical ingredient. , 2012, Journal of pharmaceutical and biomedical analysis.
[26] B. Rajkapoor,et al. DEVELOPMENT OF ZOLMITRIPTAN GEL FOR NASAL ADMINISTRATION , 2012 .
[27] S. Karavana,et al. Rheological and mechanical properties of poloxamer mixtures as a mucoadhesive gel base , 2011, Pharmaceutical development and technology.
[28] David S. Jones,et al. In‐situ gel formulations of econazole nitrate: preparation and in‐vitro and in‐vivo evaluation , 2011, The Journal of pharmacy and pharmacology.
[29] S. Dey,et al. Nasal drug delivery: An approach of drug delivery through nasal route , 2011 .
[30] G. Awad,et al. Role of edge activators and surface charge in developing ultradeformable vesicles with enhanced skin delivery. , 2010, International journal of pharmaceutics.
[31] R. Quirion,et al. Tyrosine-based rivastigmine-loaded organogels in the treatment of Alzheimer's disease. , 2010, Biomaterials.
[32] Shagufta Khan,et al. Formulation of intranasal mucoadhesive temperature-mediated in situ gel containing ropinirole and evaluation of brain targeting efficiency in rats , 2010, Journal of drug targeting.
[33] M. Samanta,et al. Poly(n-butylcyanoacrylate) nanoparticles coated with polysorbate 80 for the targeted delivery of rivastigmine into the brain to treat Alzheimer's disease , 2008, Brain Research.
[34] R. Hardy,et al. Effect of Drug Solubility on Polymer Hydration and Drug Dissolution from Polyethylene Oxide (PEO) Matrix Tablets , 2008, AAPS PharmSciTech.
[35] R. Murthy,et al. Thermoreversible-mucoadhesive Gel for nasal delivery of sumatriptan , 2006, AAPS PharmSciTech.
[36] N. M. Zaki,et al. Enhanced bioavailability of metoclopramide HCl by intranasal administration of a mucoadhesive in situ gel with modulated rheological and mucociliary transport properties. , 2007, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.
[37] E. Aguglia,et al. Rivastigmine in the treatment of Alzheimer’s disease: an update , 2007, Clinical interventions in aging.
[38] Chunjie Wu,et al. Optimization and physicochemical characterization of thermosensitive poloxamer gel containing puerarin for ophthalmic use. , 2006, Chemical & pharmaceutical bulletin.
[39] H. Altunay,et al. Nasal absorption of metoclopramide from different Carbopol 981 based formulations: In vitro, ex vivo and in vivo evaluation. , 2006, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.
[40] R. Sharma,et al. Intranasal mucoadhesive microemulsions of clonazepam: preliminary studies on brain targeting. , 2006, Journal of pharmaceutical sciences.
[41] G. Bonacucina,et al. Rheological, adhesive and release characterisation of semisolid Carbopol/tetraglycol systems. , 2006, International journal of pharmaceutics.
[42] A. Maitra,et al. Labeling efficiency and biodistribution of Technetium-99m labeled nanoparticles: interference by colloidal tin oxide particles. , 2005, International journal of pharmaceutics.
[43] David S. Jones,et al. Textural Analysis and Flow Rheometry of Novel, Bioadhesive Antimicrobial Oral Gels , 1997, Pharmaceutical Research.
[44] F. Merkus,et al. Effects of Absorption Enhancers on Rat Nasal Epithelium in Vivo: Release of Marker Compounds in the Nasal Cavity , 1995, Pharmaceutical Research.
[45] Bradley R Williams,et al. A review of rivastigmine: a reversible cholinesterase inhibitor. , 2003, Clinical therapeutics.
[46] J. Remon,et al. Rheological study on mucoadhesivity of some nasal powder formulations. , 2003, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.
[47] L. Illum. Nasal drug delivery--possibilities, problems and solutions. , 2003, Journal of controlled release : official journal of the Controlled Release Society.
[48] Y. Oh,et al. Rheological evaluation of thermosensitive and mucoadhesive vaginal gels in physiological conditions. , 2002, International journal of pharmaceutics.
[49] A. El-Kamel. In vitro and in vivo evaluation of Pluronic F127-based ocular delivery system for timolol maleate. , 2002, International journal of pharmaceutics.
[50] Jeong-Sook Park,et al. rhEGF/HP-β-CD complex in poloxamer gel for ophthalmic delivery , 2002 .
[51] S. Davis,et al. Development of a novel nasal nicotine formulation comprising an optimal pulsatile and sustained plasma nicotine profile for smoking cessation. , 2002, Journal of controlled release : official journal of the Controlled Release Society.
[52] Chong-K. Kim,et al. Effect of sodium chloride on the gelation temperature, gel strength and bioadhesive force of poloxamer gels containing diclofenac sodium. , 2001, International journal of pharmaceutics.
[53] S. Mallapragada,et al. Understanding drug release from poly(ethylene oxide)-b-poly(propylene oxide)-b-poly(ethylene oxide) gels. , 2001, Journal of controlled release : official journal of the Controlled Release Society.
[54] D. Katz,et al. Rheological properties of contraceptive gels. , 2000, Contraception.
[55] H. Goel,et al. Evaluation of (99m)Tc-labeled photosan-3, a hematoporphyrin derivative, as a potential radiopharmaceutical for tumor scintigraphy. , 2000, Nuclear medicine and biology.
[56] H. Choi,et al. Effect of additives on the physicochemical properties of liquid suppository bases. , 1999, International journal of pharmaceutics.
[57] Chong-K. Kim,et al. Increased bioavailability of propranolol in rats by retaining thermally gelling liquid suppositories in the rectum. , 1999, Journal of controlled release : official journal of the Controlled Release Society.
[58] R. Polinsky,et al. Clinical pharmacology of rivastigmine: a new-generation acetylcholinesterase inhibitor for the treatment of Alzheimer's disease. , 1998, Clinical therapeutics.
[59] Y. Oh,et al. In situ gelling and mucoadhesive liquid suppository containing acetaminophen : Enhanced bioavailability , 1998 .
[60] J. Blanchard,et al. In vitro evaluation of pluronic F127-based controlled-release ocular delivery systems for pilocarpine. , 1998, Journal of pharmaceutical sciences.
[61] Dahl,et al. Anatomy, physiology and function of the nasal cavities in health and disease. , 1998, Advanced drug delivery reviews.
[62] Schipper,et al. Nasal mucociliary clearance as a factor in nasal drug delivery. , 1998, Advanced drug delivery reviews.
[63] David S. Jones,et al. Textural, viscoelastic and mucoadhesive properties of pharmaceutical gels composed of cellulose polymers , 1997 .
[64] Guojie Xu,et al. Influence of formulation change on drug release kinetics from hydroxypropylmethylcellulose matrix tablets. , 1995, Chemical & pharmaceutical bulletin.
[65] I. Tung. Rheological behavior of poloxamer 407 aqueous solutions during sol-gel and dehydration processes , 1994 .
[66] F. Merkus,et al. Absorption enhancers in nasal drug delivery: efficacy and safety , 1993 .
[67] J. Hadgraft,et al. The effect of solutes and polymers on the gelation properties of pluronic F-127 solutions for controlled drug delivery , 1987 .
[68] N. Peppas. Analysis of Fickian and non-Fickian drug release from polymers. , 1985, Pharmaceutica acta Helvetiae.
[69] Gordon L. Amidon,et al. Thermodynamic studies on the gel-sol transition of some pluronic polyols , 1984 .