Antimicrobial Characterization of CEM-101: Activity Against Enterococci, Uncommon Gram-positive Pathogens, N. gonorrhoeae and Anaerobes

Results: CEM-101 potency against enterococci showed a bimodal distribution (0.03 and 2 μg/ml), and that activity was 2and ≥ 32-fold superior to TEL and AZ, respectively. Against E. faecalis CEM-101 activity (MIC90, 2 μg/ml) was like amoxicillin/clavulanate (MIC90, 1 μg/ml) and linezolid (MIC90, 2 μg/ml). CEM-101 MIC90 for Bacillus spp., Listeria spp. and Micrococcus spp. was 0.03 μg/ml, but 0.5 μg/ml for Corynebacterium spp. Gonococci had all CEM-101 MIC results at ≤ 0.25 μg/ml, 4-fold more potent than AZ. Anaerobe CEM-101 MIC90 results varied from > 32 (B. fragilis, C. difficile) to (Prevotella spp.) ≤ 0.25 μg/ml (Gram-positive [GP] spp).

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