Enhancement of transepidermal skin clearing agent delivery using a 980 nm diode laser

Patient compliant optical skin clearing requires non‐invasive topical delivery of clearing agents such as glycerol. This requires reducing the skin barrier function by disrupting stratum corneum integrity, which was achieved using a 980 nm diode laser with artificial absorption substrates on the skin surface. Reduction of light scattering has the potential to improve many current and novel diagnostic and therapeutic applications of lasers in medicine.

[1]  Thomas E. Milner,et al.  Feasibility of extracting tissue optical properties from amplitude OCT data during optical skin clearing , 2005, SPIE BiOS.

[2]  Bernard Choi,et al.  Determination of chemical agent optical clearing potential using in vitro human skin , 2005, Lasers in surgery and medicine.

[3]  J. Nelson,et al.  Group refractive index measurement of dry and hydrated type I collagen films using optical low-coherence reflectometry. , 1996, Journal of biomedical optics.

[4]  V V Tuchin,et al.  Light propagation in tissues with controlled optical properties , 1996, European Conference on Biomedical Optics.

[5]  Ashley J. Welch,et al.  OCT analysis of microneedle and Er:YAG surface ablation for enhanced transdermal delivery of hyperosmotic agents for optical skin clearing , 2004, SPIE BiOS.

[6]  A J Welch,et al.  Use of osmotically active agents to alter optical properties of tissue: Effects on the detected fluorescence signal measured through skin , 2001, Lasers in surgery and medicine.

[7]  H. G. Rylander,et al.  Use of an agent to reduce scattering in skin , 1999, Lasers in surgery and medicine.

[8]  V V Tuchin,et al.  Coherent optical techniques for the analysis of tissue structure and dynamics. , 1999, Journal of biomedical optics.

[9]  C. Potten.  Biological Effects of Ultraviolet Radiation with Emphasis on Human Responses to Longwave Ultraviolet , 1980, British Journal of Cancer.

[10]  Valery V. Tuchin,et al.  Concurrent enhancement of imaging depth and contrast for optical coherence tomography by hyperosmotic agents , 2001 .

[11]  N. Kollias,et al.  Photomechanical delivery of 100‐nm microspheres through the stratum corneum: Implications for transdermal drug delivery , 2002, Lasers in surgery and medicine.

[12]  S L Jacques,et al.  Mid-infrared laser ablation of stratum corneum enhances in vitro percutaneous transport of drugs. , 1991, The Journal of investigative dermatology.

[13]  Ruikang K. Wang,et al.  Dynamic optical clearing effect of tissue impregnated with hyperosmotic agents and studied with optical coherence tomography. , 2004, Journal of biomedical optics.