Multiple molecular pathways stimulating macroautophagy protect from alpha-synuclein-induced toxicity in human neurons

[1]  A. Bertolotti,et al.  Regulation of proteasome assembly and activity in health and disease , 2018, Nature Reviews Molecular Cell Biology.

[2]  W. Wurst,et al.  Exosomal secretion of α-synuclein as protective mechanism after upstream blockage of macroautophagy , 2018, Cell Death & Disease.

[3]  C. Moussa,et al.  Activating Autophagy as a Therapeutic Strategy for Parkinson’s Disease , 2018, CNS Drugs.

[4]  Dennis W Dickson,et al.  Neuropathology of Parkinson disease. , 2018, Parkinsonism & related disorders.

[5]  W. Oertel,et al.  Protective efficacy of phosphodiesterase-1 inhibition against alpha-synuclein toxicity revealed by compound screening in LUHMES cells , 2017, Scientific Reports.

[6]  H. Ho,et al.  Subcellular Parkinson’s Disease-Specific Alpha-Synuclein Species Show Altered Behavior in Neurodegeneration , 2016, Molecular Neurobiology.

[7]  Jaeil Ahn,et al.  Nilotinib Effects in Parkinson’s disease and Dementia with Lewy bodies , 2016, Journal of Parkinson's disease.

[8]  J. Ferreira,et al.  Do patients with late-stage Parkinson's disease still respond to levodopa? , 2016, Parkinsonism & related disorders.

[9]  Sangeeta Khare,et al.  Guidelines for the use and interpretation of assays formonitoring autophagy (3rd edition) , 2016 .

[10]  P. Marsden,et al.  Expression in Cardiac Myocytes In Vitro and In Vivo p 38 MAP Kinase Signaling Cascade Regulates Cyclooxygenase-2 − MAP Kinase Kinase 6 , 2003 .

[11]  Di Chen,et al.  FGFR3/fibroblast growth factor receptor 3 inhibits autophagy through decreasing the ATG12–ATG5 conjugate, leading to the delay of cartilage development in achondroplasia , 2015, Autophagy.

[12]  A. Lang,et al.  Parkinson's disease , 2015, The Lancet.

[13]  April A. Cox,et al.  Inhibition of Calpain Activation Protects MPTP-Induced Nigral and Spinal Cord Neurodegeneration, Reduces Inflammation, and Improves Gait Dynamics in Mice , 2015, Molecular Neurobiology.

[14]  M. Xilouri,et al.  Chaperone mediated autophagy to the rescue: A new-fangled target for the treatment of neurodegenerative diseases , 2015, Molecular and Cellular Neuroscience.

[15]  L. Tan,et al.  The link between the SNCA gene and parkinsonism , 2015, Neurobiology of Aging.

[16]  Brianne A. Kent,et al.  Calpain inhibition mediates autophagy-dependent protection against polyglutamine toxicity , 2014, Cell Death and Differentiation.

[17]  C. Culmsee,et al.  Trifluoperazine rescues human dopaminergic cells from wild-type α-synuclein-induced toxicity , 2014, Neurobiology of Aging.

[18]  Weimin Wang,et al.  Temozolomide induces autophagy via ATM‑AMPK‑ULK1 pathways in glioma. , 2014, Molecular medicine reports.

[19]  L. Smeeth,et al.  The association between Parkinson's disease and anti-epilepsy drug carbamazepine: a case-control study using the UK General Practice Research Database. , 2013, British journal of clinical pharmacology.

[20]  C. Slomianny,et al.  Calcium-permeable ion channels in control of autophagy and cancer , 2013, Front. Physiol..

[21]  K. Brunden,et al.  Lewy Body-like α-Synuclein Aggregates Resist Degradation and Impair Macroautophagy*♦ , 2013, The Journal of Biological Chemistry.

[22]  G. Kroemer,et al.  Molecular mechanisms of selective autophagy , 2012, Cell Death and Differentiation.

[23]  H. Braak,et al.  100 years of Lewy pathology , 2013, Nature Reviews Neurology.

[24]  M. Komatsu,et al.  Autophagy: More Than a Nonselective Pathway , 2012, International journal of cell biology.

[25]  Robert Clarke,et al.  Guidelines for the use and interpretation of assays for monitoring autophagy , 2012 .

[26]  Jihye Park,et al.  Autophagy-regulating small molecules and their therapeutic applications. , 2012, Chemical Society reviews.

[27]  D. Rubinsztein,et al.  Control of autophagy as a therapy for neurodegenerative disease , 2012, Nature Reviews Neurology.

[28]  Jian Li,et al.  Microautophagy: lesser-known self-eating , 2011, Cellular and Molecular Life Sciences.

[29]  K. Lim,et al.  Enhanced Autophagy from Chronic Toxicity of Iron and Mutant A53T α-Synuclein , 2011, The Journal of Biological Chemistry.

[30]  N. Banik,et al.  Calpain inhibition attenuates apoptosis of retinal ganglion cells in acute optic neuritis. , 2011, Investigative ophthalmology & visual science.

[31]  Y. Baran,et al.  Imatinib induces autophagy through BECLIN‐1 and ATG5 genes in chronic myeloid leukemia cells , 2011, Hematology.

[32]  Fred H. Gage,et al.  In vivo demonstration that α-synuclein oligomers are toxic , 2011, Proceedings of the National Academy of Sciences.

[33]  V. Choubey,et al.  Mutant A53T α-Synuclein Induces Neuronal Death by Increasing Mitochondrial Autophagy* , 2011, The Journal of Biological Chemistry.

[34]  M. Demirci.  Comprehensive Clinical Nephrology 3rd Edition , 2011 .

[35]  D. Rubinsztein,et al.  Chemical modulators of autophagy as biological probes and potential therapeutics. , 2011, Nature chemical biology.

[36]  M. DiFiglia,et al.  The mTOR kinase inhibitor Everolimus decreases S6 kinase phosphorylation but fails to reduce mutant huntingtin levels in brain and is not neuroprotective in the R6/2 mouse model of Huntington's disease , 2010, Molecular Neurodegeneration.

[37]  S. Murakami,et al.  NF449 Is a Novel Inhibitor of Fibroblast Growth Factor Receptor 3 (FGFR3) Signaling Active in Chondrocytes and Multiple Myeloma Cells* , 2010, The Journal of Biological Chemistry.

[38]  D. Rubinsztein,et al.  Chemical Inducers of Autophagy That Enhance the Clearance of Mutant Proteins in Neurodegenerative Diseases , 2010, The Journal of Biological Chemistry.

[39]  A. Criollo,et al.  Crosstalk between apoptosis and autophagy within the Beclin 1 interactome , 2010, The EMBO journal.

[40]  C. Warren Olanow,et al.  Alterations in lysosomal and proteasomal markers in Parkinson's disease: Relationship to alpha-synuclein inclusions , 2009, Neurobiology of Disease.

[41]  E. Morselli,et al.  The inositol 1,4,5-trisphosphate receptor regulates autophagy through its interaction with Beclin 1 , 2009, Cell Death and Differentiation.

[42]  David Park,et al.  Abberant α-Synuclein Confers Toxicity to Neurons in Part through Inhibition of Chaperone-Mediated Autophagy , 2009, PloS one.

[43]  David P. Davis,et al.  Akt inhibition promotes autophagy and sensitizes PTEN-null tumors to lysosomotropic agents , 2008, The Journal of cell biology.

[44]  Kostas Vekrellis,et al.  Wild Type α-Synuclein Is Degraded by Chaperone-mediated Autophagy and Macroautophagy in Neuronal Cells* , 2008, Journal of Biological Chemistry.

[45]  Ralph A. Nixon,et al.  Autophagy Induction and Autophagosome Clearance in Neurons: Relationship to Autophagic Pathology in Alzheimer's Disease , 2008, The Journal of Neuroscience.

[46]  D. Rubinsztein,et al.  Novel targets for Huntington's disease in an mTOR-independent autophagy pathway. , 2008, Nature chemical biology.

[47]  N. Mizushima,et al.  Autophagy: process and function. , 2007, Genes & development.

[48]  N. Mizushima,et al.  How to Interpret LC3 Immunoblotting , 2007, Autophagy.

[49]  J. Duyster,et al.  The anticancer drug imatinib induces cellular autophagy , 2007, Leukemia.

[50]  B. Nico,et al.  A novel cell type-specific role of p38α in the control of autophagy and cell death in colorectal cancer cells , 2007, Cell Death and Differentiation.

[51]  Mark Stacy,et al.  Medical Management of Levodopa-Associated Motor Complications in Patients with Parkinson’s Disease , 2007, CNS drugs.

[52]  Thomas Schaffner,et al.  Calpain-mediated cleavage of Atg5 switches autophagy to apoptosis , 2006, Nature Cell Biology.

[53]  Jeppe Falsig,et al.  Progressive Degeneration of Human Mesencephalic Neuron-Derived Cells Triggered by Dopamine-Dependent Oxidative Stress Is Dependent on the Mixed-Lineage Kinase Pathway , 2005, The Journal of Neuroscience.

[54]  Peter T. Lansbury,et al.  Impaired Degradation of Mutant α-Synuclein by Chaperone-Mediated Autophagy , 2004, Science.

[55]  Jeremy N. Skepper,et al.  α-Synuclein Is Degraded by Both Autophagy and the Proteasome* , 2003, Journal of Biological Chemistry.

[56]  M. L. Greenberg,et al.  Myo-inositol-1-phosphate (MIP) synthase: a possible new target for antibipolar drugs. , 2002, Bipolar disorders.

[57]  A. Björklund,et al.  Parkinson-Like Neurodegeneration Induced by Targeted Overexpression of α-Synuclein in the Nigrostriatal System , 2002, The Journal of Neuroscience.

[58]  S. Henry,et al.  1L-myo-inositol-1-phosphate synthase. , 1997, Biochimica et biophysica acta.

[59]  R. Parthasarathy,et al.  Myo-Inositol Monophosphatase: Diverse Effects of Lithium, Carbamazepine, and Valproate , 1995, Neuropsychopharmacology.

[60]  J. Atack,et al.  In Vitro and In Vivo Inhibition of Inositol Monophosphatase by the Bisphosphonate L‐690,330 , 1993, Journal of neurochemistry.

[61]  P. Godfrey,et al.  Alteration of inositol phospholipid metabolism in rat cortex by lithium but not carbamazepine. , 1988, European journal of pharmacology.