Predicting Functional Decline and Recovery for Residents in Veterans Affairs Nursing Homes.

PURPOSE OF THE STUDY This article describes methods and accuracy of predicting change in activities of daily living (ADLs) for nursing home patients following hospitalization. DESIGN AND METHODS Electronic Health Record data for 5,595 residents of Veterans Affairs' (VAs') Community Living Centers (CLCs) aged 70 years and older were analyzed within the VA Informatics and Computing Infrastructure. Data included diagnoses from 7,106 inpatient records, 21,318 functional status evaluations, and 69,140 inpatient diagnoses. The Barthel Index extracted from CLC's Minimum Data Set was used to assess ADLs loss and recovery. Patients' diagnoses on hospital admission, ADL status prior to hospitalization, age, and gender were used alone or in combination to predict ADL loss/gain following hospitalization. Area under the Receiver-Operator Curve (AUC) was used to report accuracy of predictions in short (14 days) and long-term (15-365 days) follow-up post-hospitalization. RESULTS Admissions fell into 7 distinct patterns of recovery and loss: early recovery 19%, delayed recovery 9%, delayed recovery after temporary decline 9%, early decline 29%, delayed decline 10%, delayed decline after temporary recovery 6%, and no change 18%. Models accurately predicted ADL's 14-day post-hospitalization (AUC for bathing 0.917, bladder 0.842, bowels 0.875, dressing 0.871, eating 0.867, grooming 0.902, toileting 0.882, transfer 0.852, and walking deficits was 0.882). Accuracy declined but remained relatively high when predicting 14-365 days post-hospitalization (AUC ranging from 0.798 to 0.875). IMPLICATIONS Predictive modeling may allow development of more personalized predictions of functional loss and recovery after hospitalization among nursing home patients.

[1]  B. Resnick,et al.  Functional decline in hospitalized older adults: can nursing make a difference? , 2012, Geriatric nursing.

[2]  R. Kane,et al.  The Effect of Evercare on Hospital Use , 2003, Journal of the American Geriatrics Society.

[3]  Sylvain Trepanier,et al.  Detection of Older People at Increased Risk of Adverse Health Outcomes After an Emergency Visit: The ISAR Screening Tool , 1999, Journal of the American Geriatrics Society.

[4]  R. Fortinsky,et al.  A randomized trial of care in a hospital medical unit especially designed to improve the functional outcomes of acutely ill older patients. , 1995, The New England journal of medicine.

[5]  M. Pahor,et al.  Reducing “iatrogenic disability” in the hospitalized frail elderly , 2011, The journal of nutrition, health & aging.

[6]  H. Allore,et al.  Establishing a Hierarchy for the Two Components of Restricted Activity. , 2015, The journals of gerontology. Series A, Biological sciences and medical sciences.

[7]  B Cooper,et al.  Improving the sensitivity of the Barthel Index for stroke rehabilitation. , 1989, Journal of clinical epidemiology.

[8]  T M Morgan,et al.  Functional outcomes of acute medical illness and hospitalization in older persons. , 1996, Archives of internal medicine.

[9]  M. Trabucchi,et al.  Functional trajectories during hospitalization: a prognostic sign for elderly patients. , 2009, The journals of gerontology. Series A, Biological sciences and medical sciences.

[10]  J Concato,et al.  Importance of functional measures in predicting mortality among older hospitalized patients. , 1998, JAMA.

[11]  E. McCarthy,et al.  Dying with Cancer: Patients' Function, Symptoms, and Care Preferences as Death Approaches , 2000, Journal of the American Geriatrics Society.

[12]  H. Allore,et al.  Factors associated with recovery of prehospital function among older persons admitted to a nursing home with disability after an acute hospitalization. , 2009, The journals of gerontology. Series A, Biological sciences and medical sciences.

[13]  W. De Alfieri,et al.  Acute functional decline before hospitalization in older patients , 2014, Geriatrics & gerontology international.

[14]  Mary T. Fox,et al.  Acute Care for Elders Components of Acute Geriatric Unit Care: Systematic Descriptive Review , 2013, Journal of the American Geriatrics Society.

[15]  P. Couturier,et al.  Loss of independence in Katz’s ADL ability in connection with an acute hospitalization: early clinical markers in French older people , 2007, European Journal of Epidemiology.

[16]  Steve R. Fisher,et al.  Mobility Activity and Its Value as a Prognostic Indicator of Survival in Hospitalized Older Adults , 2013, Journal of the American Geriatrics Society.

[17]  A. Mudge,et al.  Timing and risk factors for functional changes associated with medical hospitalization in older patients. , 2010, The journals of gerontology. Series A, Biological sciences and medical sciences.

[18]  Kwong-Sak Leung,et al.  Substituting random forest for multiple linear regression improves binding affinity prediction of scoring functions: Cyscore as a case study , 2014, BMC Bioinformatics.

[19]  W. De Alfieri,et al.  Functional Recovery of Elderly Patients Hospitalized in Geriatric and General Medicine Units. The PROgetto DImissioni in GEriatria Study , 2011, Journal of the American Geriatrics Society.

[20]  R. Kane,et al.  Patterns of Utilization for the Minnesota Senior Health Options Program , 2004, Journal of the American Geriatrics Society.

[21]  H. Allore,et al.  The relationship between intervening hospitalizations and transitions between frailty states. , 2011, The journals of gerontology. Series A, Biological sciences and medical sciences.

[22]  K. Covinsky,et al.  Measuring Prognosis and Case Mix in Hospitalized Elders: The Importance of Functional Status , 1997, Journal of General Internal Medicine.

[23]  Graziano Onder,et al.  Characteristics of Nondisabled Older Patients Developing New Disability Associated with Medical Illnesses and Hospitalization , 2007, Journal of General Internal Medicine.

[24]  อนิรุธ สืบสิงห์,et al.  Data Mining Practical Machine Learning Tools and Techniques , 2014 .

[25]  J. Mahoney,et al.  Frequency of hallway ambulation by hospitalized older adults on medical units of an academic hospital. , 2004, Geriatric nursing.

[26]  Dheeraj Raju,et al.  Exploring factors associated with pressure ulcers: a data mining approach. , 2015, International journal of nursing studies.

[27]  D. Wade,et al.  The Barthel ADL Index: a standard measure of physical disability? , 1988, International disability studies.

[28]  C. Landefeld Improving Health Care for Older Persons , 2003, Annals of Internal Medicine.

[29]  C. Winograd,et al.  The Natural History of Functional Morbidity in Hospitalized Older Patients , 1990, Journal of the American Geriatrics Society.

[30]  Thomas M Gill,et al.  Change in disability after hospitalization or restricted activity in older persons. , 2010, JAMA.

[31]  H. Cohen,et al.  Effect of a geriatric consultation team on functional status of elderly hospitalized patients. A randomized, controlled clinical trial. , 1989, Annals of Internal Medicine.

[32]  R. Kane,et al.  Effect of an innovative medicare managed care program on the quality of care for nursing home residents. , 2004, The Gerontologist.

[33]  M. Dellefield,et al.  Implementation of the resident assessment instrument/minimum data set in the nursing home as organization: implications for quality improvement in RN clinical assessment. , 2007, Geriatric nursing.

[34]  K. Putman,et al.  Analysis of Rehabilitation Activities within Skilled Nursing and Inpatient Rehabilitation Facilities After Hip Replacement for Acute Hip Fracture , 2010, American journal of physical medicine & rehabilitation.

[35]  S. Inouye,et al.  The Overlap Syndrome of Depression and Delirium in Older Hospitalized Patients , 2009, Journal of the American Geriatrics Society.

[36]  G. Ostir,et al.  Assessing gait speed in acutely ill older patients admitted to an acute care for elders hospital unit. , 2012, Archives of internal medicine.

[37]  B. Resnick,et al.  Impact of care settings on residents' functional and psychosocial status, physical activity and adverse events. , 2015, International journal of older people nursing.

[38]  Ian H. Witten,et al.  Data mining - practical machine learning tools and techniques, Second Edition , 2005, The Morgan Kaufmann series in data management systems.

[39]  L. Beckett,et al.  Acute delirium and functional decline in the hospitalized elderly patient. , 1993, Journal of gerontology.

[40]  R. Fortinsky,et al.  Effects of a Multicomponent Intervention on Functional Outcomes and Process of Care in Hospitalized Older Patients: A Randomized Controlled Trial of Acute Care for Elders (ACE) in a Community Hospital , 2000, Journal of the American Geriatrics Society.

[41]  B. Resnick,et al.  Pilot Testing of Function-Focused Care for Acute Care Intervention , 2011, Journal of nursing care quality.

[42]  M. Catani,et al.  Elderly patients with cognitive impairment have a high risk for functional decline during hospitalization: The GIFA Study. , 2005, The journals of gerontology. Series A, Biological sciences and medical sciences.

[43]  Chun-Hou Wang,et al.  Establishing the Minimal Clinically Important Difference of the Barthel Index in Stroke Patients , 2007, Neurorehabilitation and neural repair.

[44]  Leo Breiman,et al.  Random Forests , 2001, Machine Learning.

[45]  B. Resnick,et al.  Function focused care approaches: literature review of progress and future possibilities. , 2013, Journal of the American Medical Directors Association.

[46]  Thomas M Gill,et al.  Trajectories of disability in the last year of life. , 2010, The New England journal of medicine.

[47]  P. Griffin,et al.  Use of random forest to estimate population attributable fractions from a case-control study of Salmonella enterica serotype Enteritidis infections , 2015, Epidemiology and Infection.

[48]  Joel Tsevat,et al.  Predicting Functional Status Outcomes in Hospitalized Patients Aged 80 Years and Older , 2000, Journal of the American Geriatrics Society.

[49]  A. Stewart,et al.  Loss of Independence in Activities of Daily Living in Older Adults Hospitalized with Medical Illnesses: Increased Vulnerability with Age , 2003, Journal of the American Geriatrics Society.

[50]  P de Jonge,et al.  COMPRI--an instrument to detect patients with complex care needs: results from a European study. , 2001, Psychosomatics.

[51]  S. Sahadevan,et al.  Factors associated with functional decline of hospitalised older persons following discharge from an acute geriatric unit. , 2006, Annals of the Academy of Medicine, Singapore.

[52]  R. Fortinsky,et al.  Reports of financial disability predict functional decline and death in older patients discharged from the hospital , 2005, Journal of General Internal Medicine.

[53]  B. Resnick,et al.  Testing a Family‐Centered Intervention to Promote Functional and Cognitive Recovery in Hospitalized Older Adults , 2014, Journal of the American Geriatrics Society.

[54]  Sharon K. Inouye,et al.  A predictive index for functional decline in hospitalized elderly medical patients , 1993, Journal of General Internal Medicine.

[55]  H. Allore,et al.  Functional Trajectories in Older Persons Admitted to a Nursing Home with Disability After an Acute Hospitalization , 2009, Journal of the American Geriatrics Society.

[56]  Muhammad Jalaluddin,et al.  Hospital Admission Risk Profile (HARP): Identifying Older Patients at Risk for Functional Decline Following Acute Medical Illness and Hospitalization , 1996, Journal of the American Geriatrics Society.

[57]  R. Kane,et al.  The Outcome of Hospitalization for Acute Illness in the Elderly , 1983, Journal of the American Geriatrics Society.

[58]  R. Kakuma,et al.  Predictors of functional decline in hospitalized elderly patients: a systematic review. , 2002, The journals of gerontology. Series A, Biological sciences and medical sciences.

[59]  J. Guralnik,et al.  Predictive value of the Short Physical Performance Battery following hospitalization in older patients. , 2011, The journals of gerontology. Series A, Biological sciences and medical sciences.

[60]  Elizabeth H Bradley,et al.  Understanding the treatment preferences of seriously ill patients. , 2002, The New England journal of medicine.