DVH Analysis of Cobalt-60 treatment plans incorporating a recently developed MLC

Purpose: The aim of this investigation was to measure the gain in DVH indices when the recently developed MLC was used for Cobalt-60 treatments. Methods: A prototype multileaf collimator (MLC) that was retrofitted to telecobalt-60 therapy machine was reported and is currently proposed for clinical trials in our institution. Ten patients’ plans that were previously planned through an ECLIPSE ® treatment planning system and were treated with open beams from Cobalt-60 machine were imported into Radiation Oncology Planning System [ROPS] and the dose calculations and dose volume histogram (DVH) analysis were performed. The plans were re-planned using the Cobalt-MLC, a feature available in the ROPS planning system. The DVH analysis consisted of conformity index (CI), homogeneity index (HI) and conformation number (CN). The results of this study are presented in this paper. The analysis specifically aimed at measuring the gain in these indices when the MLC was compared with open beams. Results: DVH Comparison of ten sites using open and Cobalt MLC fields showed that the use of MLC results in reduced normal tissue dose, while maintaining the GTV dose. Lower value of CI for normal structures was observed demonstrating the sparing of critical organs when MLC was used. The index HI was studied to show the significance of hot spots outside the PTV. Hot spots were observed even with MLC beams for some cases due to less number of fields. Conclusion: It has been demonstrated through DVH analysis that the use of the recently developed MLC for Cobalt Teletherapy machine results in benefit for the treatment of patients.

[1]  G. Salomons,et al.  The role of Cobalt-60 in modern radiation therapy: Dose delivery and image guidance , 2009, Journal of medical physics.

[2]  J. Rakowski,et al.  Fast Monte Carlo simulation for total body irradiation using a  60Co teletherapy unit , 2013, Journal of applied clinical medical physics.

[3]  Derek W. Brown,et al.  Cobalt, linac, or other: what is the best solution for radiation therapy in developing countries? , 2014, International journal of radiation oncology, biology, physics.

[4]  A. R. Reddy,et al.  Monte Carlo study of MLC fields for cobalt therapy machine , 2014, Journal of medical physics.

[5]  A. Piermattei,et al.  Forward-planned intensity modulated radiation therapy using a cobalt source: A dosimetric study in breast cancer , 2013, Journal of medical physics.

[6]  H. Romeijn,et al.  Comparative analysis of 60Co intensity-modulated radiation therapy. , 2008, Physics in medicine and biology.

[7]  L. Schreiner,et al.  Dosimetry of interface region near closed air cavities for Co-60, 6 MV and 15 MV photon beams using Monte Carlo simulations , 2010, Journal of medical physics.

[8]  M. Moerland,et al.  A conformation number to quantify the degree of conformality in brachytherapy and external beam irradiation: application to the prostate. , 1997, International journal of radiation oncology, biology, physics.

[9]  E. Adams,et al.  A comparison between cobalt and linear accelerator-based treatment plans for conformal and intensity-modulated radiotherapy. , 2008, The British journal of radiology.