A Case of Serratia Marcescens Keratitis Presenting as Radial Keratoneuritis

To report a case of Serratia marcescens keratitis presenting as radial keratoneuritis. clinic with severe pain and visual disturbance in her left eye. On slit lamp examination, central corneal epithelial defect and stromal infiltration with radial keratoneuritis were observed. Based on clinical findings and past history, Acanthamoeba keratitis was highly suspected. The patient was treated with topical chlorhexidine 0.02% (Sigma-Aldrich Co., MO, USA) and moxifloxacin 0.5% (Vigamox ® , Alcon, TX, USA) per hour with 200 mg of oral itraconazol (Sporaone ® , LG, Seoul, Korea) once a day. Symptoms and corneal lesions did not improve after three days. After Serratia marsenscens was isolated from her contact lenses and solution, topical chlorhexidine 0.02% was discontinued, and intravenous ceftazidime (Tazime ® , Hanmi, Seoul, Korea) and fortified ceftazidime (50 mg/mL) eye drop was added. The corneal lesion dramatically improved, and after six months of follow-up, best-corrected visual acuity was 20/20 in the affected eye. Conclusions: Radial keratoneuritis can present not only in Acanthamoeba keratitis, but also in Serratia marsenscens keratitis. Confirmation of the isolated organism is useful when treating radial keratoneuritis.

[1]  Darlene Miller,et al.  Delayed-onset endophthalmitis associated with corneal suture infections , 2013, Journal of Ophthalmic Inflammation and Infection.

[2]  Y. Matsumoto,et al.  A case of radial keratoneuritis in non-Acanthamoeba keratitis , 2012, Clinical ophthalmology.

[3]  A. Alfawaz Radial Keratoneuritis as a Presenting Sign in Acanthamoeba Keratitis , 2011, Middle East African journal of ophthalmology.

[4]  M. Hashemian,et al.  Serratia marcescens keratitis after photorefractive keratectomy. , 2009, Journal of cataract and refractive surgery.

[5]  J. Mehta,et al.  Acanthamoeba keratitis associated with contact lens wear in Singapore. , 2009, American journal of ophthalmology.

[6]  Richard Johnson,et al.  Acanthamoeba keratitis and contact lens wear , 2007, Clinical & experimental optometry.

[7]  H. Taylor,et al.  Association between cultures of contact lens and corneal scraping in contact lens related microbial keratitis. , 2007, Archives of ophthalmology.

[8]  Robert J. Anderson,et al.  The association of contact lens solution use and Acanthamoeba keratitis. , 2007, American journal of ophthalmology.

[9]  Jong Soo Lee,et al.  Acanthamoeba keratitis related to cosmetic contact lenses , 2007, Clinical & experimental ophthalmology.

[10]  J. Sugar,et al.  Epidemiological characteristics of a Chicago-area Acanthamoeba keratitis outbreak. , 2006, American journal of ophthalmology.

[11]  E. Cohen,et al.  Serratia Corneal Ulcers: A Retrospective Clinical Study , 2005, Cornea.

[12]  G. Alexandrakis,et al.  Shifting trends in bacterial keratitis in south Florida and emerging resistance to fluoroquinolones. , 2000, Ophthalmology.

[13]  J. Sugar,et al.  Radial keratoneuritis in Pseudomonas keratitis. , 1991, Archives of ophthalmology.