Clinical Practice Recommendations

During the past 3 years, Clinical Diabetes has published “Diabetes Foundation,” a 12-part series intended to explain and review facets of diabetes care for general physicians and physicians in training. The goal of the series has been to improve diabetes care for patients treated by such physicians because only a very small percentage of patients with diabetes have access to an endocrinologist. Although previous articles have focused on individual topics related to diabetes care and have reviewed available scientific data, this final article will focus on summarizing recommendations from the American Diabetes Association (ADA) and integrating them as a set of clinical practice guidelines. Information supporting the recommendations has appeared in the previous installments of “Diabetes Foundation” and from the ADA. Although there are always exceptions, it is likely that the majority of patients with diabetes or glucose abnormalities would benefit from implementation of many of these guidelines for both prevention of diabetes and prevention of the complications of diabetes and diabetes treatments. Whom to Screen for Diabetes or Pre-Diabetes Any patient who is experiencing symptoms of diabetes such as polyuria, polydipsia, or unexplained weight loss should be screened for diabetes, especially if they are obese or overweight (BMI > 25 kg/m2). Asymptomatic adult patients should be tested at any age if they are overweight or obese and have an additional risk factor for diabetes. Children who are overweight (BMI greater than the 85th percentile or weight > 120% of ideal for height) should be screened for type 2 diabetes if they have a family history of type 2 diabetes, are of an ethnic background predisposed to diabetes, have signs of insulin resistance such as acanthosis nigricans on physical examination, have a maternal history of diabetes or gestational diabetes, or have other conditions typically associated with type 2 diabetes. Such testing in children should begin at the age of 10 years or at the onset of puberty. If tests are normal, such patients should be screened again in 3 years. Women who have had gestational diabetes should be screened for diabetes 6–12 weeks postpartum.

[1]  E. Tangalos,et al.  CME Practice parameter: , 2022 .

[2]  T. Hortobágyi,et al.  Depressive Symptoms in Alzheimer’s Disease and Lewy Body Dementia: A One-Year Follow-Up Study , 2011, Dementia and Geriatric Cognitive Disorders.

[3]  Miriam C J M Sturkenboom,et al.  Inappropriate drug prescribing in older adults: the updated 2002 Beers criteria--a population-based cohort study. , 2005, British journal of clinical pharmacology.

[4]  R. Castellani,et al.  Alzheimer disease. , 2010, Disease-a-month : DM.

[5]  M. Weiner,et al.  A randomized, controlled study of an Alzheimer's caregiver skills training program , 2005, American journal of Alzheimer's disease and other dementias.

[6]  D. Perani,et al.  Anosognosia in Very Mild Alzheimer’s Disease but Not in Mild Cognitive Impairment , 2005, Dementia and Geriatric Cognitive Disorders.

[7]  Lee Bowman,et al.  Impact of cognitive impairment on mild dementia patients and mild cognitive impairment patients and their informants , 2006, International Psychogeriatrics.

[8]  M. Waern,et al.  Predictors of Suicide in the Old Elderly , 2003, Gerontology.

[9]  S Antani,et al.  Metacognitive deficits in frontotemporal dementia , 2005, Journal of Neurology, Neurosurgery & Psychiatry.

[10]  C. Drebing,et al.  Documenting pathways to dementia care: Relative validity of questionnaire, interview, and medical record formats , 2004, American journal of Alzheimer's disease and other dementias.

[11]  K. Mehta,et al.  Cognitive Impairment, Depressive Symptoms, and Functional Decline in Older People , 2002, Journal of the American Geriatrics Society.

[12]  P. Werner Knowledge about symptoms of Alzheimer's disease: correlates and relationship to help‐seeking behavior , 2003, International journal of geriatric psychiatry.

[13]  K. Milisen,et al.  Multicomponent intervention strategies for managing delirium in hospitalized older people: systematic review. , 2005, Journal of advanced nursing.

[14]  V. Preedy,et al.  Prospective Cohort Study , 2010 .

[15]  C. Monaghan,et al.  Dementia diagnosis and disclosure: a dilemma in practice. , 2004, Journal of clinical nursing.

[16]  D. Gass,et al.  Screening for Cognitive Impairment and Dementia in the Elderly , 2001, Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques.

[17]  H. Brodaty,et al.  Suicidal ideation and the 'wish to die' in dementia patients: the role of depression. , 1998, Age and ageing.

[18]  M. Catani,et al.  Validation of the Five‐Item Geriatric Depression Scale in Elderly Subjects in Three Different Settings , 2003, Journal of the American Geriatrics Society.

[19]  R. Petersen,et al.  A collaborative study of the emergence and clinical features of the major depressive syndrome of Alzheimer's disease. , 2003, The American journal of psychiatry.

[20]  D. Selkoe Alzheimer's disease. , 2011, Cold Spring Harbor perspectives in biology.

[21]  Brian R Ott,et al.  Amnestic Behavior in Dementia: Symptoms to Assist in Early Detection and Diagnosis , 2003, Journal of the American Geriatrics Society.

[22]  A. Mackinnon,et al.  The cognitive decline scale of the psychogeriatric assessment scales (PAS): longitudinal data on its validity , 2001, International journal of geriatric psychiatry.

[23]  C. Lyketsos,et al.  Prevalence of neuropsychiatric symptoms in dementia and mild cognitive impairment: results from the cardiovascular health study. , 2002, JAMA.

[24]  S. Iliffe,et al.  Early recognition of dementia by nurses. , 2003, Journal of advanced nursing.

[25]  C. Franz,et al.  Pathways to Dementia Diagnosis: Evidence for Cross-Ethnic Differences , 2004, Alzheimer disease and associated disorders.

[26]  Thanh-Thu T. Tran,et al.  Screening for Early Alzheimer's Disease: Is There Still a Role for the Mini-Mental State Examination? , 2005, Primary care companion to the Journal of clinical psychiatry.

[27]  Stephen Salloway,et al.  Executive dysfunction and apathy predict functional impairment in Alzheimer disease. , 2003, The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry.

[28]  J. Cummings,et al.  The Montreal Cognitive Assessment, MoCA: A Brief Screening Tool For Mild Cognitive Impairment , 2005, Journal of the American Geriatrics Society.

[29]  L. Wahlund,et al.  Impaired verb fluency: A sign of mild cognitive impairment , 2005, Brain and Language.

[30]  M. Marzanski Would you like to know what is wrong with you? On telling the truth to patients with dementia , 2000, Journal of medical ethics.

[31]  P A Parmelee,et al.  Geriatric Depression Scale , 2002 .

[32]  J Ballenger Depression in Patients With Mild Cognitive Impairment Increases the Risk of Developing Dementia of Alzheimer Type: A Prospective Cohort StudyModrego PJ, Ferrández J (Hosp de Alcañiz, Spain) Arch Neurol 61:1290–1293, 2004§ , 2006 .

[33]  S. Manson,et al.  American Indians/Alaska Natives and Dementia , 2002, Alzheimer disease and associated disorders.

[34]  G. Livingston,et al.  Secrets and lies: the dilemma of disclosing the diagnosis to an adult with dementia. , 2003, Age and ageing.

[35]  R. Green,et al.  Depression as a risk factor for Alzheimer disease: the MIRAGE Study. , 2003, Archives of neurology.

[36]  H. J. Husband,et al.  Diagnostic disclosure in dementia: an opportunity for intervention? , 2000, International journal of geriatric psychiatry.

[37]  Oscar L Lopez,et al.  Depressive symptoms, vascular disease, and mild cognitive impairment: findings from the Cardiovascular Health Study. , 2006, Archives of general psychiatry.

[38]  M. Delazer,et al.  Clock Drawing, Clock Reading, Clock Setting, and Judgment of Clock Faces in Elderly People with Dementia and Depression , 2004, Journal of the American Geriatrics Society.

[39]  Philip Scheltens,et al.  The impact of diagnostic disclosure in dementia: a qualitative case analysis , 2005, International Psychogeriatrics.

[40]  Richard Schulz,et al.  Dementia caregiver intervention research: in search of clinical significance. , 2002, The Gerontologist.

[41]  C. Patterson,et al.  The Recognition, Assessment and Management of Dementing Disorders: Conclusions from the Canadian Consensus Conference on Dementia , 1999, Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques.

[42]  Cynthia Owsley,et al.  Timed Instrumental Activities of Daily Living Tasks: Relationship to Cognitive Function and Everyday Performance Assessments in Older Adults , 2002, Gerontology.

[43]  C. Becker,et al.  Factors relating to the use of physical restraints in psychogeriatric care: A paradigm for elder abuse , 2005, Zeitschrift für Gerontologie und Geriatrie (Print).

[44]  C. Derouesné [Mini-mental state examination]. , 2001, Revue neurologique.

[45]  P. Allebeck,et al.  Life events and psychosocial factors in elderly suicides – a case–control study , 2001, Psychological Medicine.

[46]  V. Camus,et al.  Factor analysis supports the evidence of existing hyperactive and hypoactive subtypes of delirium , 2000, International journal of geriatric psychiatry.

[47]  S K Inouye,et al.  Clarifying confusion: the confusion assessment method. A new method for detection of delirium. , 1990, Annals of internal medicine.

[48]  S. Inouye,et al.  Delirium Superimposed on Dementia: A Systematic Review , 2002, Journal of the American Geriatrics Society.

[49]  J. Henrard,et al.  Major depression as a risk factor for early institutionalization of dementia patients living in the community , 2005, International journal of geriatric psychiatry.

[50]  M. Albert,et al.  Clinical features associated with costs in early AD , 2006, Neurology.

[51]  S. Engelborghs,et al.  Neuropsychiatric symptoms of dementia: cross‐sectional analysis from a prospective, longitudinal Belgian study , 2005, International journal of geriatric psychiatry.

[52]  D. Salmon,et al.  Frontal behavioral syndromes and functional status in probable Alzheimer disease. , 2003, The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry.

[53]  V. Wadley,et al.  Loss of calculation abilities in patients with mild and moderate Alzheimer disease. , 2003, Archives of neurology.

[54]  R. Cheston,et al.  Group psychotherapy and people with dementia , 2003, Aging & mental health.

[55]  B. L. Beattie,et al.  Disclosing a Diagnosis of Alzheimer’s Disease: Patient and Family Experiences , 2001, Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques.

[56]  D. Cahn-Weiner,et al.  Neuropsychological Predictors of Everyday Memory and Everyday Functioning in Patients with Mild Alzheimer's Disease , 2003, Journal of geriatric psychiatry and neurology.

[57]  J. Bates,et al.  Psychosocial interventions for people with a milder dementing illness: a systematic review. , 2004, Journal of advanced nursing.

[58]  N. Dendukuri,et al.  Does Delirium Increase Hospital Stay? , 2003, Journal of the American Geriatrics Society.

[59]  L. Rubenstein,et al.  Development and Testing of a Five‐Item Version of the Geriatric Depression Scale , 1999, Journal of the American Geriatrics Society.

[60]  H. Richardson,et al.  A comparison of scoring protocols on the Clock Drawing Test in relation to ease of use, diagnostic group, and correlations with Mini-Mental State Examination. , 2002, Journal of the American Geriatrics Society.

[61]  A. Biderman,et al.  Depression and falls among community dwelling elderly people: a search for common risk factors , 2002, Journal of epidemiology and community health.

[62]  Nandini Dendukuri,et al.  Risk factors for depression among elderly community subjects: a systematic review and meta-analysis. , 2003, The American journal of psychiatry.

[63]  E. Olsson,et al.  Motor Function in Subjects with Mild Cognitive Impairment and Early Alzheimer’s Disease , 2005, Dementia and Geriatric Cognitive Disorders.

[64]  B. Mulsant,et al.  Is delirium different when it occurs in dementia? A study using the delirium rating scale. , 1998, The Journal of neuropsychiatry and clinical neurosciences.

[65]  S. Inouye,et al.  Delirium superimposed on dementia in a community-dwelling managed care population: a 3-year retrospective study of occurrence, costs, and utilization. , 2005, The journals of gerontology. Series A, Biological sciences and medical sciences.

[66]  J. Traphagan,et al.  Cultural Factors in Dementia: Perspectives from the Anthropology of Aging , 2005, Alzheimer disease and associated disorders.

[67]  O. Almeida,et al.  Short versions of the geriatric depression scale: a study of their validity for the diagnosis of a major depressive episode according to ICD‐10 and DSM‐IV , 1999, International journal of geriatric psychiatry.

[68]  K. Milisen,et al.  Cognitive assessment and differentiating the 3 Ds (dementia, depression, delirium). , 2006, The Nursing clinics of North America.

[69]  W. Jagust,et al.  Degree of discrepancy between self and other‐reported everyday functioning by cognitive status: dementia, mild cognitive impairment, and healthy elders , 2005, International journal of geriatric psychiatry.

[70]  C. Ashton,et al.  Treatable comorbid conditions and use of VA health care services among patients with dementia. , 2005, Psychiatric services.

[71]  K. Wild,et al.  Identifying Driving Impairment in Alzheimer Disease: A Comparison of Self and Observer Reports Versus Driving Evaluation , 2003, Alzheimer disease and associated disorders.

[72]  W. Bouman,et al.  Attitudes of Patients With Mild Dementia and Their Carers Towards Disclosure of the Diagnosis , 2003, International Psychogeriatrics.

[73]  S. Iliffe,et al.  The Implications of the Early Recognition of Dementia for Multiprofessional Teamworking , 2003 .

[74]  A. Monsch,et al.  Assessment of everyday behavior in Alzheimer's disease patients: Its significance for diagnostics and prediction of disease progression , 2005, American journal of Alzheimer's disease and other dementias.

[75]  R. Ownby,et al.  Relationship of behavioral and psychological symptoms to cognitive impairment and functional status in Alzheimer's disease , 2000, International journal of geriatric psychiatry.

[76]  D. Knopman,et al.  Patterns of Care in the Early Stages of Alzheimer's Disease: Impediments to Timely Diagnosis , 2000, Journal of the American Geriatrics Society.

[77]  Michal Abrahamowicz,et al.  Delirium predicts 12-month mortality. , 2002, Archives of internal medicine.

[78]  M. Beers,et al.  Updating the Beers criteria for potentially inappropriate medication use in older adults: results of a US consensus panel of experts. , 2003, Archives of internal medicine.

[79]  Ismo Räihä,et al.  Diagnosing cognitive impairment and dementia in primary health care -- a more active approach is needed. , 2003, Age and ageing.

[80]  Charles D. Smith,et al.  The characteristics of dementia caregiving onset , 2003, American journal of Alzheimer's disease and other dementias.

[81]  C. Delaporte Ways of announcing a late-onset, heritable, disabling disease and their psychological consequences. , 1996, Genetic counseling.

[82]  Ling Han,et al.  The Prognostic Significance of Subsyndromal Delirium in Elderly Medical Inpatients , 2003, Journal of the American Geriatrics Society.

[83]  Y. Stern,et al.  Functional deficits in patients with mild cognitive impairment: Prediction of AD , 2002, Neurology.

[84]  K. Langa,et al.  Additive effects of cognitive function and depressive symptoms on mortality in elderly community-living adults. , 2003, The journals of gerontology. Series A, Biological sciences and medical sciences.

[85]  C. Mateer,et al.  Awareness of financial skills in dementia , 2004, Aging & mental health.

[86]  B. Reisberg,et al.  Equilibrium and Limb Coordination in Mild Cognitive Impairment and Mild Alzheimer's Disease , 1999, Journal of the American Geriatrics Society.

[87]  S. Newman,et al.  Psychosocial interventions for caregivers of people with dementia: a systematic review. , 2001, Aging & mental health.

[88]  Theodore Speroff,et al.  Evaluation of delirium in critically ill patients: Validation of the Confusion Assessment Method for the Intensive Care Unit (CAM-ICU) , 2001, Critical care medicine.

[89]  S. Anderson,et al.  Driver landmark and traffic sign identification in early Alzheimer’s disease , 2005, Journal of Neurology, Neurosurgery & Psychiatry.

[90]  H. Dodge,et al.  Cognitive impairment as a strong predictor of incident disability in specific ADL-IADL tasks among community-dwelling elders: the Azuchi Study. , 2005, The Gerontologist.

[91]  L. Clare Managing threats to self: awareness in early stage Alzheimer's disease. , 2003, Social science & medicine.

[92]  C. Lyketsos,et al.  Characteristics and outcomes of dementia residents in an assisted living facility , 2000, International journal of geriatric psychiatry.

[93]  P. Werner Factors influencing intentions to seek a cognitive status examination: a study based on the Health Belief Model , 2003, International journal of geriatric psychiatry.

[94]  B L Miller,et al.  Self awareness and personality change in dementia , 2005, Journal of Neurology, Neurosurgery & Psychiatry.

[95]  A. Juby,et al.  The value of clock drawing in identifying executive cognitive dysfunction in people with a normal Mini-Mental State Examination score. , 2002, CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne.