Textiles which have direct contact with the skin should have appropriate biophysical properties. There are especially high requirements of textiles used by hospitalised patients, who remain in bed in a prone position for a long time. The paper will present the results of the analysis connected with designing sheet fabrics with biophysical properties aimed at creating an appropriate surrounding for the patient’s body. In the textile selection the following elements will be analysed: composition (hydrophilic fibres - cotton; hydrophobic fibres - polypropylene fibres and their spatial distribution), the product’s weave and con struction (embossed fabrics and satin fabrics). The paper will present the following results of laboratory research examining hygienic comfort under the following categories: vapour permeability, air permeability and water absorption. The paper will also present the results of their assessment when confronted with the results of the application research carried out in hospitals. The application research was carried out at the Department of Anaesthesiology and Intensive Care Medicine, Barlicki Clinic of the Medical Academy of Łodź and at the Department of Rehabilitation, Łask Hospital.