Aiming for safe anticoagulation.

Since its discovery more than 50 years ago, warfarin has endured as a remarkable drug and is now the 14th-largest-selling medication in the United States. The efficacy of oral anticoagulant therapy...

[1]  P. Koudstaal.  Optimal oral anticoagulant therapy in patients with nonrheumatic atrial fibrillation and recent cerebral ischemia. , 1995, The New England journal of medicine.

[2]  J. Vandenbroucke,et al.  Optimal oral anticoagulant therapy in patients with mechanical heart valves. , 1995, The New England journal of medicine.

[3]  J. Gardin,et al.  Prevalence of atrial fibrillation in elderly subjects (the Cardiovascular Health Study). , 1994, The American journal of cardiology.

[4]  R. White,et al.  Outpatient Use of a Portable International Normalized Ratio/Prothrombin Time Monitor , 1994, Southern medical journal.

[5]  Donald Martin,et al.  Risk Factors for Complications of Chronic Anticoagulation: A Multicenter Study , 1993, Annals of Internal Medicine.

[6]  J. Hirsh,et al.  Heparin: mechanism of action, pharmacokinetics, dosing considerations, monitoring, efficacy, and safety. , 1992, Chest.

[7]  D L Kent,et al.  A Model for Planning Optimal Follow-up for Outpatients on Warfarin Anticoagulation , 1992, Medical decision making : an international journal of the Society for Medical Decision Making.

[8]  J. Heaf,et al.  Bleeding complications to oral anticoagulant therapy: multivariate analysis of 1010 treatment years in 551 outpatients , 1991, Journal of internal medicine.

[9]  E. Gurfinkel,et al.  Comparison of two levels of anticoagulant therapy in patients with substitute heart valves. , 1991, The Journal of thoracic and cardiovascular surgery.

[10]  A. Gallus,et al.  Trial of different intensities of anticoagulation in patients with prosthetic heart valves. , 1990, The New England journal of medicine.

[11]  J. Hirsh,et al.  "Therapeutic range" for oral anticoagulant therapy. , 1986, Chest.