Hepatic metabolism of insulin.

[1]  W. Duckworth,et al.  Insulin metabolism and degradation. , 1981, Endocrine reviews.

[2]  W. Duckworth,et al.  The degradation of monoiodotyrosyl insulin isomers by insulin protease. , 1984, Endocrinology.

[3]  B. Posner,et al.  Effect of chloroquine on the internalization of 125I-insulin into subcellular fractions of rat liver. Evidence for an effect of chloroquine on Golgi elements. , 1982, The Journal of biological chemistry.

[4]  P. Pilch,et al.  The beta subunit of the insulin receptor is an insulin-activated protein kinase. , 1983, Biochemistry.

[5]  W. Duckworth,et al.  Selective effects of inhibitors of hormone processing on insulin action in isolated hepatocytes. , 1984, Endocrinology.

[6]  B. Posner,et al.  Endocytosis of peptide hormones and other ligands. , 1982, Endocrine reviews.

[7]  B. Draznin,et al.  Inhibition of intracellular proteolysis by insulin in isolated rat hepatocytes. Possible role of internalized hormone. , 1982, The Journal of biological chemistry.

[8]  W. Duckworth Insulin degradation: mechanisms, products, and significance. , 1988, Endocrine reviews.

[9]  A. Kitabchi,et al.  Early Detection of Degraded A14-125I-Insulin in Human Fibroblasts by the Use of High Performance Liquid Chromatography , 1983, Diabetes.

[10]  A. Ullrich,et al.  Human insulin receptors mutated at the ATP-binding site lack protein tyrosine kinase activity and fail to mediate postreceptor effects of insulin. , 1987, The Journal of biological chemistry.

[11]  D. Steiner,et al.  Binding and degradation of 125I-insulin by rat hepatocytes. , 1975, The Journal of biological chemistry.

[12]  R. Roth,et al.  Defective internalization of insulin and its receptor in cells expressing mutated insulin receptors lacking kinase activity. , 1987, The Journal of biological chemistry.

[13]  Identification of A chain cleavage sites in intact insulin produced by insulin protease and isolated hepatocytes. , 1987, Biochemical and biophysical research communications.

[14]  W. Duckworth,et al.  Evidence that Bacitracin Alters Intracellular Insulin Metabolism in Isolated Rat Hepatocytes , 1985, Diabetes.

[15]  W. Duckworth,et al.  HPLC Analysis of Insulin Degradation Products From Isolated Hepatocytes: Effects of Inhibitors Suggest Intracellular and Extracellular Pathways , 1987, Diabetes.

[16]  E. L. Johnson,et al.  The protein-tyrosine kinase activity of the insulin receptor is necessary for insulin-mediated receptor down-regulation. , 1987, The Journal of biological chemistry.

[17]  K. Amano,et al.  Insulin-degrading enzyme is capable of degrading receptor-bound insulin. , 1988, Biochemical and biophysical research communications.

[18]  C. Kahn,et al.  Insulin stimulates tyrosine phosphorylation of the insulin receptor in a cell-free system , 1982, Nature.

[19]  W. Duckworth,et al.  Degradation products of insulin generated by hepatocytes and by insulin protease. , 1988, The Journal of biological chemistry.

[20]  W. Duckworth,et al.  Receptor Binding Properties of Monoiodotyrosyl Insulin Isomers Purified by High Performance Liquid Chromatography , 1983, Diabetes.

[21]  W. Duckworth,et al.  Isolation of insulin degradation products from endosomes derived from intact rat liver. , 1988, The Journal of biological chemistry.

[22]  W. Duckworth,et al.  Localization of insulin degradation products to an intracellular site in isolated rat hepatocytes. , 1986, Biochemical and biophysical research communications.

[23]  W. Duckworth,et al.  High performance liquid chromatographic analysis of insulin degradation by rat skeletal muscle insulin protease. , 1986, Endocrinology.

[24]  W. Duckworth,et al.  Receptor binding and biological activity of specifically labeled [125I]- and [127I]monoiodoinsulin isomers in isolated rat adipocytes. , 1984, Endocrinology.

[25]  D. Morgan,et al.  Acute insulin action requires insulin receptor kinase activity: introduction of an inhibitory monoclonal antibody into mammalian cells blocks the rapid effects of insulin. , 1987, Proceedings of the National Academy of Sciences of the United States of America.

[26]  I. Goldfine The insulin receptor: molecular biology and transmembrane signaling. , 1987, Endocrine reviews.

[27]  B. Posner,et al.  Characterization of rat liver endosomal fractions. In vivo activation of insulin-stimulable receptor kinase in these structures. , 1986, The Journal of biological chemistry.

[28]  R. Roth,et al.  Insulin receptor: evidence that it is a protein kinase. , 1983, Science.