Functionalized superparamagnetic nanoparticles with a polymer containing β-cyclodextrin for the extraction of sertraline hydrochloride in biological samples.

In this study, a novel magnetic nanoadsorbent was synthesized by grafting β-cyclodextrin onto the modified surface of Fe3 O4 nanoparticles for the sorption and extraction of sertraline hydrochloride from human biological fluids. The extracted sertraline hydrochloride was measured by high-performance liquid chromatography. The grafted nanosorbent was confirmed by Fourier transform infrared spectroscopy, transmission electron microscopy, thermogravimetric analysis, and elemental analysis. The kinetic sorption of sertraline hydrochloride by magnetic nanosorbent was 1 h. The best temperature for sorption of sertraline hydrochloride was at 25°C at an optimum pH of 5. The adsorbed sertraline hydrochloride can be desorbed by using methanol solution containing acetic acid (5%) and trifluoroacetic acid (1%).

[1]  G. Vladisavljević,et al.  Mass transfer resistance in a liquid-phase microextraction employing a single hollow fiber under unsteady-state conditions. , 2012, Journal of separation science.

[2]  H. A. Panahi,et al.  Hollow-fiber-supported liquid membrane microextraction of amlodipine and atorvastatin. , 2014, Journal of separation science.

[3]  J. M. Cortés,et al.  Comparison of two extraction methods for the determination of selective serotonin reuptake inhibitors in sewage sludge by hollow fiber liquid-phase microextraction. , 2012, Journal of separation science.

[4]  C. Serna,et al.  Advances in magnetic nanoparticles for biotechnology applications , 2005 .

[5]  Y. Tu,et al.  The electrochemical behavior and oxidation mechanism of sertraline on a rutin modified electrode , 2012 .

[6]  F. D. de Sousa,et al.  Multi-equilibrium system based on sertraline and β-cyclodextrin supramolecular complex in aqueous solution. , 2011, International journal of pharmaceutics.

[7]  Y. Chevalier,et al.  Emulsions of β-cyclodextrins grafted to silicone for the transport of antifungal drugs , 2008 .

[8]  A. Niazi,et al.  Flotation-assisted homogeneous liquid–liquid microextraction for determination of thorium in water samples by inductively coupled plasma–mass spectrometry and Box–Behnken design , 2017 .

[9]  S. Bayari,et al.  Ab initio and density functional computations of the vibrational spectrum, molecular geometry and some molecular properties of the antidepressant drug sertraline (Zoloft) hydrochloride. , 2007, Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy.

[10]  Annett Rechtenbach,et al.  Synthesis and physical characterization of magnetite nanoparticles for biomedical applications , 2008 .

[11]  H. Ahmad panahi,et al.  Magnetic iron oxide nanoparticles grafted N-isopropylacrylamide/chitosan copolymer for the extraction and determination of letrozole in human biological samples. , 2017, Journal of separation science.

[12]  H. Ebrahimzadeh,et al.  Optimization of ion-pair based hollow fiber liquid phase microextraction combined with HPLC-UV for the determination of methimazole in biological samples and animal feed. , 2012, Journal of separation science.

[13]  C. Nerín,et al.  Three-phase hollow-fiber liquid-phase microextraction combined with HPLC-UV for the determination of isothiazolinone biocides in adhesives used for food packaging materials. , 2014, Journal of separation science.

[14]  E. Sellers,et al.  Comparative abuse liability of sertraline, alprazolam, and dextroamphetamine in humans. , 1995, Journal of clinical psychopharmacology.

[15]  V. Dravid,et al.  Self-assembled (SA) bilayer molecular coating on magnetic nanoparticles , 2001 .

[16]  Warrington Sj.  Clinical implications of the pharmacology of sertraline. , 1991 .

[17]  S. Warrington.  Clinical Implications of the Pharmacology of Sertraline , 1991, International clinical psychopharmacology.

[18]  S. Athanaselis,et al.  Development and validation of an EI-GC/MS method for the determination of sertraline and its major metabolite desmethyl-sertraline in blood. , 2011, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

[19]  P. Marquet,et al.  Methods for the determination of seven selective serotonin reuptake inhibitors and three active metabolites in human serum using high-performance liquid chromatography and gas chromatography. , 2000, Journal of chromatography. B, Biomedical sciences and applications.

[20]  D. Berardi,et al.  HPLC analysis of the second-generation antidepressant sertraline and its main metabolite N-desmethylsertraline in human plasma. , 2006, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

[21]  C. Hsu,et al.  Orbital polarization and Jahn–Teller distortion of strained La0.5Sr0.5MnO3 thin films , 2007 .

[22]  Homayon Ahmad Panahi,et al.  Synthesis and characterization of poly[N-isopropylacrylamide-co-1-(N,N-bis-carboxymethyl)amino-3-allylglycerol] grafted to magnetic nano-particles for the extraction and determination of fluvoxamine in biological and pharmaceutical samples. , 2014, Journal of chromatography. A.

[23]  A. Niazi,et al.  Analytical approaches for the determination of cobalt, nickel and copper by aeration-assisted homogeneous liquid–liquid microextraction and flame atomic absorption spectrometry , 2016 .

[24]  G. Frija,et al.  Liver positive enhancement after injection of superparamagnetic nanoparticles: respective role of circulating and uptaken particles. , 1997, Magnetic resonance imaging.

[25]  D. Figgitt,et al.  Sertraline , 2000 .

[26]  J. Markowitz,et al.  Clinical Pharmacokinetics of Sertraline , 2002, Clinical pharmacokinetics.

[27]  Christine Frahnert,et al.  Analysis of eighteen antidepressants, four atypical antipsychotics and active metabolites in serum by liquid chromatography: a simple tool for therapeutic drug monitoring. , 2003, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.