Case–Control Study of Breast Cancer in India: Role of PERIOD3 Clock Gene Length Polymorphism and Chronotype

Background: This study examined a PERIOD3 (PER3) gene variable number tandem repeat polymorphism and chronotype as potential BrCA risk factors among Indian women. Methods: This case–control study included sporadic, histologically confirmed BrCA cases (n = 255) and controls (n = 249) from India with data collection from 2010–2012. Results: Women with the 4/5 or 5/5 PER3 genotype had a nonstatistically significant 33% increased odds of BrCA. Cases were more likely to have a morning (OR = 2.43, 95% CI = 1.23–4.81) or evening (OR = 2.55, 95% CI = 1.19–5.47) chronotype. Conclusions: Findings are consistent with the possibility that extremes in chronotype may elicit circadian desynchronization, resulting in increased BrCA susceptibility.

[1]  S. Hankinson,et al.  Chronotype and Breast Cancer Risk in a Cohort of US Nurses , 2013, Chronobiology international.

[2]  R. Vermeulen,et al.  The association between different night shiftwork factors and breast cancer: a case–control study , 2013, British Journal of Cancer.

[3]  H. Brauch,et al.  Night work and breast cancer estrogen receptor status--results from the German GENICA study. , 2013, Scandinavian journal of work, environment & health.

[4]  J. Spinelli,et al.  Increased risk of breast cancer associated with long-term shift work in Canada , 2013, Occupational and Environmental Medicine.

[5]  V. Salomaa,et al.  Associations of Chronotype and Sleep With Cardiovascular Diseases and Type 2 Diabetes , 2013, Chronobiology international.

[6]  T. Åkerstedt,et al.  Breast cancer among shift workers: results of the WOLF longitudinal cohort study. , 2013, Scandinavian journal of work, environment & health.

[7]  P. Guénel,et al.  Night work and breast cancer: A population‐based case–control study in France (the CECILE study) , 2013, International journal of cancer.

[8]  L. Fritschi,et al.  Self-reported sleep duration, sleep quality, and breast cancer risk in a population-based case-control study. , 2013, American journal of epidemiology.

[9]  T. Erren.  Shift work and cancer research: can chronotype predict susceptibility in night-shift and rotating-shift workers? , 2013, Occupational and Environmental Medicine.

[10]  J. Burch,et al.  Disruption of Circadian Rhythms and Sleep: Role in Carcinogenesis , 2013 .

[11]  J. Violanti,et al.  Association of the Period3 clock gene length polymorphism with salivary cortisol secretion among police officers. , 2013, Neuro endocrinology letters.

[12]  Ilona Merikanto,et al.  Circadian clock disruptions and the risk of cancer , 2012, Annals of medicine.

[13]  Olaf Neumann,et al.  Methylome analysis and integrative profiling of human HCCs identify novel protumorigenic factors , 2012, Hepatology.

[14]  P. Bhatti,et al.  Invited commentary: Shift work and cancer. , 2012, American journal of epidemiology.

[15]  J. Siemiatycki,et al.  Night work and the risk of cancer among men. , 2012, American journal of epidemiology.

[16]  C. Eastman,et al.  Blacks (African Americans) Have Shorter Free-Running Circadian Periods Than Whites (Caucasian Americans) , 2012, Chronobiology international.

[17]  R. Stevens,et al.  Case-control study of shift-work and breast cancer risk in Danish nurses: impact of shift systems. , 2012, European journal of cancer.

[18]  Johnni Hansen,et al.  Nested case–control study of night shift work and breast cancer risk among women in the Danish military , 2012, Occupational and Environmental Medicine.

[19]  Céline Vetter,et al.  Social Jetlag and Obesity , 2012, Current Biology.

[20]  T. Laatikainen,et al.  Relation of Chronotype to Sleep Complaints in the General Finnish Population , 2012, Chronobiology international.

[21]  Dawei Li,et al.  Reduced Expression of PER3 Is Associated with Incidence and Development of Colon Cancer , 2012, Annals of Surgical Oncology.

[22]  Derk-Jan Dijk,et al.  Sleep, Diurnal Preference, Health, and Psychological Well-being: A Prospective Single-Allelic-Variation Study , 2012, Chronobiology international.

[23]  R. Sarin,et al.  Multiple Pathway-Based Genetic Variations Associated with Tobacco Related Multiple Primary Neoplasms , 2012, PloS one.

[24]  X. Gu,et al.  The circadian mutation PER2S662G is linked to cell cycle progression and tumorigenesis , 2011, Cell Death and Differentiation.

[25]  Till Roenneberg,et al.  Depression Scores Associate With Chronotype and Social Jetlag in a Rural Population , 2011, Chronobiology international.

[26]  S. Pallesen,et al.  Association Study of a Variable-Number Tandem Repeat Polymorphism in the Clock Gene PERIOD3 and Chronotype in Norwegian University Students , 2011, Chronobiology international.

[27]  J. Mill,et al.  Sleep quality and diurnal preference in a sample of young adults: Associations with 5HTTLPR, PER3, and CLOCK 3111 , 2011, American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics.

[28]  K. Shibui,et al.  Relation between morningness-eveningness score and depressive symptoms among patients with delayed sleep phase syndrome. , 2011, Sleep medicine.

[29]  S. Pallesen,et al.  Individual differences in tolerance to shift work--a systematic review. , 2011, Sleep medicine reviews.

[30]  S. Zienolddiny,et al.  American Journal of Epidemiology Original Contribution Night Work and Breast Cancer Risk among Norwegian Nurses: Assessment by Different Exposure Metrics , 2022 .

[31]  Daniel J Buysse,et al.  Circadian type and bed-timing regularity in 654 retired seniors: correlations with subjective sleep measures. , 2011, Sleep.

[32]  Wei Zhang,et al.  The role of polymorphisms in circadian pathway genes in breast tumorigenesis , 2011, Breast Cancer Research and Treatment.

[33]  Yoshiya Moriguchi,et al.  EVENING PREFERENCE IS RELATED TO THE INCIDENCE OF DEPRESSIVE STATES INDEPENDENT OF SLEEP-WAKE CONDITIONS , 2010, Chronobiology international.

[34]  R. Secolin,et al.  Interactions of polymorphisms in different clock genes associated with circadian phenotypes in humans , 2010, Genetics and molecular biology.

[35]  A. Balmain,et al.  Deletion of the PER3 gene on chromosome 1p36 in recurrent ER-positive breast cancer. , 2010, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[36]  A. Derossis,et al.  Is Breast Cancer the Same Disease in Asian and Western Countries? , 2010, World Journal of Surgery.

[37]  D. Dijk,et al.  PERIOD3, circadian phenotypes, and sleep homeostasis. , 2010, Sleep medicine reviews.

[38]  Céline Vetter,et al.  Shift-work research: Where do we stand, where should we go? , 2010 .

[39]  S. Gery,et al.  Circadian rhythms and cancer , 2010, Cell cycle.

[40]  K. Straif,et al.  Painting, firefighting, and shiftwork. , 2010, IARC monographs on the evaluation of carcinogenic risks to humans.

[41]  S. Tufik,et al.  Do Caucasian and Asian clocks tick differently? , 2010, Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas.

[42]  V. Natale,et al.  Depressive symptomatology is influenced by chronotypes. , 2009, Journal of affective disorders.

[43]  Patricia A. Wood,et al.  Clock Genes and Cancer , 2009, Integrative cancer therapies.

[44]  R. Stevens.  Working against our endogenous circadian clock: Breast cancer and electric lighting in the modern world. , 2009, Mutation research.

[45]  J. Hébert,et al.  Mapping cancer mortality‐to‐incidence ratios to illustrate racial and sex disparities in a high‐risk population , 2009, Cancer.

[46]  Enrico Smeraldi,et al.  A length polymorphism in the circadian clock gene Per3 influences age at onset of bipolar disorder , 2008, Neuroscience Letters.

[47]  D. Dijk,et al.  Inter-individual differences in habitual sleep timing and entrained phase of endogenous circadian rhythms of BMAL1, PER2 and PER3 mRNA in human leukocytes. , 2008, Sleep.

[48]  M. Gordijn,et al.  Epidemiology of the human circadian clock. , 2007, Sleep medicine reviews.

[49]  G. O'Connor,et al.  Genome-wide association of sleep and circadian phenotypes , 2007, BMC Medical Genetics.

[50]  J. Kaprio,et al.  Heritability of diurnal type: a nationwide study of 8753 adult twin pairs , 2007, Journal of sleep research.

[51]  Christopher R. Jones,et al.  Modeling of a Human Circadian Mutation Yields Insights into Clock Regulation by PER2 , 2007, Cell.

[52]  T. Ebisawa,et al.  Circadian rhythms in the CNS and peripheral clock disorders: human sleep disorders and clock genes. , 2007, Journal of pharmacological sciences.

[53]  P. Gupta,et al.  Stage at diagnosis and relative differences in breast and prostate cancer incidence in India: comparison with the United States. , 2006, Asian Pacific journal of cancer prevention : APJCP.

[54]  Dirk H. Hellhammer,et al.  Morningness and eveningness: The free cortisol rise after awakening in “early birds” and “night owls” , 2006, Biological Psychology.

[55]  M. Wittmann,et al.  Social Jetlag: Misalignment of Biological and Social Time , 2006, Chronobiology international.

[56]  Jan-Gowth Chang,et al.  Disturbance of circadian gene expression in endometrial cancer: detection by real-time quantitative RT-PCR. , 2005, Oncology reports.

[57]  M. Weale,et al.  Evolution of a Length Polymorphism in the Human PER3 Gene, a Component of the Circadian System , 2005, Journal of biological rhythms.

[58]  Ming-Feng Hou,et al.  Deregulated expression of the PER1, PER2 and PER3 genes in breast cancers. , 2005, Carcinogenesis.

[59]  Tongzhang Zheng,et al.  Period3 structural variation: a circadian biomarker associated with breast cancer in young women. , 2005, Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology.

[60]  Nelson A. M. Lemos,et al.  Association of the length polymorphism in the human Per3 gene with the delayed sleep-phase syndrome: does latitude have an influence upon it? , 2005, Sleep.

[61]  P. V. Noord.  Breast Cancer and the Brain: a Neurodevelopmental Hypothesis to Explain the Opposing Effects of Caloric Deprivation during the Dutch Famine of 1944–1945 on Breast Cancer and Its Risk Factors , 2004 .

[62]  P. V. van Noord.  Breast cancer and the brain: a neurodevelopmental hypothesis to explain the opposing effects of caloric deprivation during the Dutch famine of 1944-1945 on breast cancer and its risk factors. , 2004, The Journal of nutrition.

[63]  Josephine Arendt,et al.  A length polymorphism in the circadian clock gene Per3 is linked to delayed sleep phase syndrome and extreme diurnal preference. , 2003, Sleep.

[64]  T. Paunio,et al.  Circadian Clock-Related Polymorphisms in Seasonal Affective Disorder and their Relevance to Diurnal Preference , 2003, Neuropsychopharmacology.

[65]  B. Yeole,et al.  An epidemiological assessment of increasing incidence and trends in breast cancer in Mumbai and other sites in India, during the last two decades. , 2003, Asian Pacific journal of cancer prevention : APJCP.

[66]  C A Czeisler,et al.  Association of intrinsic circadian period with morningness-eveningness, usual wake time, and circadian phase. , 2001, Behavioral neuroscience.

[67]  M. Dubocovich,et al.  Familial advanced sleep phase syndrome. , 2001, Archives of neurology.

[68]  B. Bioulac,et al.  Is Self-Reported Morbidity Related to the Circadian Clock? , 2001, Journal of biological rhythms.

[69]  Christopher R. Jones,et al.  An hPer2 Phosphorylation Site Mutation in Familial Advanced Sleep Phase Syndrome , 2001, Science.

[70]  K. H. Dow,et al.  Quality of life, survivorship, and psychosocial adjustment of young women with breast cancer after breast-conserving surgery and radiation therapy. , 2000, Oncology nursing forum.

[71]  F. Ferraro,et al.  Psychometric properties of the reduced Horne and Ostberg questionnaire , 2000 .

[72]  B Bioulac,et al.  Morningness/eveningness and the need for sleep , 1999, Journal of sleep research.

[73]  Simon Folkard,et al.  The Standard Shiftwork Index: a battery of questionnaires for assessing shiftwork-related problems , 1995 .

[74]  Daniel J Buysse,et al.  The Pittsburgh sleep quality index: A new instrument for psychiatric practice and research , 1989, Psychiatry Research.