Evaluation of serum lipid concentrations among U.S. workers exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin.

2,3,7,8-Tetrachlorodibenzo-p-dioxin alters lipid metabolism in animals; however, evidence for such an effect in humans is conflicting. This conflict was addressed using data from a cross-sectional medical study conducted between 1987 and 1988. The exposed participants had been employed at least 15 y earlier in the manufacture of 2,4,5-trichlorophenol or one of its derivatives at two chemical plants in the United States. A total of 281 workers and 260 unexposed referents participated. Workers had substantial exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin, evidenced by a median serum 2,3,7,8-tetrachlorodibenzo-p-dioxin concentration of 406.6 femtograms/gram of serum (fg/g serum), compared with 36.9 fg/g serum among the referents. A slight association between triglyceride concentration and serum 2,3,7,8-tetrachlorodibenzo-p-dioxin concentration was found (p = .05). Over the range of observed 2,3,7,8-tetrachlorodibenzo-p-dioxin values (i.e., 37-19000 fg/g serum), triglyceride concentration increased only about 0.4 mmol/I. No association was found between an abnormally elevated triglyceride (i.e., > 2.82 mmol/I) concentration and serum 2,3,7,8-tetrachlorodibenzo-p-dioxin concentration. An association was also found between serum 2,3,7,8-tetrachlorodibenzo-p-dioxin concentration and an abnormal high-density lipoprotein concentration (p = .09). in summary, there was evidence of an effect on lipid metabolism in a group of workers with high serum 2,3,7,8-tetrachlorodibenzo-p-dioxin concentrations. The influence of serum 2,3,7,8-tetrachlorodibenzo-p-dioxin on lipid concentrations, however, was small, compared with the influence of other factors.

[1]  G. Myers,et al.  Blood lipid measurements: Variations and practical utility , 1992, JAMA.

[2]  W. Halperin,et al.  Evaluation of chronic bronchitis, chronic obstructive pulmonary disease, and ventilatory function among workers exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin. , 1991, The American review of respiratory disease.

[3]  D. Phillips,et al.  Chlorinated hydrocarbon levels in human serum: Effects of fasting and feeding , 1989, Archives of environmental contamination and toxicology.

[4]  W. Halperin,et al.  Progress of the NIOSH cross-sectional medical study of workers occupationally exposed to chemicals contaminated with 2,3,7,8-TCDD , 1989 .

[5]  L. L. Needham,et al.  Medical evaluation of subjects with known body levels of 2,3,7,8-tetrachlorodibenzo-p-dioxin. , 1989, Journal of toxicology and environmental health.

[6]  F. Matsumura,et al.  Rabbit serum hypertriglyceridemia after administration of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). , 1988, Journal of toxicology and environmental health.

[7]  Daniel Steinberg,et al.  Report of the National Cholesterol Education Program Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults. The Expert Panel. , 1988, Archives of internal medicine.

[8]  N. Mantel,et al.  Clinical laboratory manifestations of exposure to dioxin in children. A six-year study of the effects of an environmental disaster near Seveso, Italy. , 1986, JAMA.

[9]  K. Steinberg,et al.  Health effects of long-term exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin. , 1986, JAMA.

[10]  R Rej,et al.  Subchronic oral toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin in the guinea pig: comparisons with a PCB-containing transformer fluid pyrolysate. , 1986, Fundamental and applied toxicology : official journal of the Society of Toxicology.

[11]  R. Moore,et al.  Effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and fasting on body weight and lipid parameters in rats. , 1985, Toxicology and applied pharmacology.

[12]  J. Michalek,et al.  An Epidemiologic Investigation of Health Effects in Air Force Personnel Following Exposure to Herbicides. Extract Reproductive Outcomes Executive Summary introduction and Conclusions. , 1992 .

[13]  L. Kuller,et al.  Total and cardiovascular mortality in relation to cigarette smoking, serum cholesterol concentration, and diastolic blood pressure among black and white males followed up for five years. , 1984, American heart journal.

[14]  V. Hertzberg,et al.  Human health effects of 2,4,5-T and its toxic contaminants. , 1984, JAMA.

[15]  J. V. Martin.  Lipid abnormalities in workers exposed to dioxin. , 1984, British journal of industrial medicine.

[16]  W. Castelli,et al.  Epidemiology of coronary heart disease: the Framingham study. , 1984, The American journal of medicine.

[17]  R. Lilis,et al.  Health status of workers with past exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin in the manufacture of 2,4,5-trichlorophenoxyacetic acid: comparison of findings with and without chloracne. , 1984, American journal of industrial medicine.

[18]  G. May.  Tetrachlorodibenzodioxin: a survey of subjects ten years after exposure. , 1982, British journal of industrial medicine.

[19]  J. Pickova,et al.  The development and prognosis of chronic intoxication by tetrachlordibenzo-p-dioxin in men. , 1981, Archives of environmental health.

[20]  R. A. Neal,et al.  Toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin in the golden Syrian hamster. , 1980, Toxicology and applied pharmacology.

[21]  G. Franceschini,et al.  Increased total and high density lipoprotein cholesterol with apoprotein changes resembling streptozotocin diabetes in tetrachlorodibenzodioxin (TCDD) treated rats. , 1980, Biochemical pharmacology.

[22]  B. N. Gupta,et al.  Hematologic and clinical chemistry effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin in laboratory animals. , 1973, Environmental health perspectives.

[23]  W. Kannel,et al.  Serum cholesterol, lipoproteins, and the risk of coronary heart disease. The Framingham study. , 2020, Annals of internal medicine.