Design and Analysis of Microarray Experiments for Pharmacogenomics

7.1 Potential uses of biomarkers . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 7.2 Clinical uses of genetic profiling . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2 7.3 Two stages of pharmacogenomic development . . . . . . . . . . . . . . . . . . . . . . . . . . 3 7.4 Multiplicity in pharmacogenomics . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 5 7.5 Designing pharmacogenomic studies . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 12 7.6 Analyzing microarray data by modeling . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 17 7.7 A proof of concept experiment . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 19 7.8 Software Implementation . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 24

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