The Potential Impact of Preventive HIV Vaccines in China: Results and Benefits of a Multi-Province Modeling Collaboration

China’s commitment to implementing established and emerging HIV/AIDS prevention and control strategies has led to substantial gains in terms of access to antiretroviral treatment and prevention services, but the evolving and multifaceted HIV/AIDS epidemic in China highlights the challenges of maintaining that response. This study presents modeling results exploring the potential impact of HIV vaccines in the Chinese context at varying efficacy and coverage rates, while further exploring the potential implications of vaccination programs aimed at reaching populations at highest risk of HIV infection. A preventive HIV vaccine would add a powerful tool to China’s response, even if not 100% efficacious or available to the full population.

[1]  T. Brown,et al.  Updates to the Spectrum/Estimation and Projection Package (EPP) model to estimate HIV trends for adults and children , 2012, Sexually Transmitted Infections.

[2]  C. Latkin,et al.  Assessment of changes in risk behaviors during 3 years of posttrial follow-up of male circumcision trial participants uncircumcised at trial closure in Rakai, Uganda. , 2012, American journal of epidemiology.

[3]  S. Swindells,et al.  Prevention of HIV-1 infection with early antiretroviral therapy , 2011, Journal of Family Planning and Reproductive Health Care.

[4]  M. G. Fonseca,et al.  Modeling HIV Vaccines in Brazil: Assessing the Impact of a Future HIV Vaccine on Reducing New Infections, Mortality and Number of People Receiving ARV , 2010, PloS one.

[5]  L. Bollinger.  How can we calculate the “E” in “CEA”? , 2008, AIDS.

[6]  J. Stover,et al.  The impact of an AIDS vaccine in developing countries: a new model and initial results. , 2007, Health affairs.

[7]  Stephen Moses,et al.  Male circumcision for HIV prevention in young men in Kisumu, Kenya: a randomised controlled trial , 2007, The Lancet.

[8]  David F. Gordon.  The Next Wave of HIV/AIDS: Nigeria, Ethiopia, Russia, India, and China , 2002 .

[9]  J. Leichliter,et al.  Human papillomavirus vaccine and sexual behavior among adolescent and young women. , 2012, American journal of preventive medicine.

[10]  N. Michael,et al.  Joint United Nations Programme on HIV/AIDS. , 2004, Military medicine.