Studies Utilizing Murine T Cell Clones Ir Genes, Ia Antigens and MLR Stimulating Determinants

Approximately 3 years ago, in Vol. 35, we presented preliminary data regarding the potential for cloning murine alloreactive T cells {Watanabe et al. 1977). Subsequently it has been possible for us to isolate and characterize clones of murine alloreactive T cells {Fathman & Hengartner 1978, 1979a, 1979b, Hengartner & Fathman 1980) and clones of murine T cells reactive with soluble antigens (Kimoto & Fathman 1980). Utilizing clones reactive with alloantigens, as well as clones reactive with soluble antigens in combination with monoclonal antibodies directed at Ia antigens and a variety of congenic, recombinant congenic and mutant mice, it has been possible to demonstrate that I region encoded MLR stimulating determinants, Ia antigens and immune response genes are all associated with the same cell surface products and are indistinguishable.

[1]  M. Kimoto,et al.  Antigen-reactive T cell clones. I. Transcomplementing hybrid I-A-region gene products function effectively in antigen presentation , 1980, The Journal of experimental medicine.

[2]  C. Fathman.  Hybrid I region antigens. , 1980, Transplantation.

[3]  R. Steinman,et al.  Contribution of dendritic cells to stimulation of the murine syngeneic mixed leukocyte reaction , 1980, The Journal of experimental medicine.

[4]  J. Watson.  Continuous proliferation of murine antigen-specific helper T lymphocytes in culture , 1979, The Journal of experimental medicine.

[5]  M. Sandrin,et al.  B6.C-H-2bm12. A new H-2 mutation in the I region in the mouse , 1979, The Journal of experimental medicine.

[6]  J. Chiller,et al.  Propagation of antigen-specific T cell helper function in vitro. , 1979, Journal of immunology.

[7]  C. Fathman,et al.  Crossreactive mixed lymphocyte reaction determinants recognized by cloned alloreactive T cells. , 1979, Proceedings of the National Academy of Sciences of the United States of America.

[8]  C. Fathman,et al.  In vitro secondary MLR. III: Hybrid histocompatibility determinants. , 1978, Journal of immunology.

[9]  B. Benacerraf.  Opinion A Hypothesis to Relate the Specificity of T Lymphocytes and the Activity of I Region-Specific Ir Genes in Macrophages and B Lymphocytes , 1978 .

[10]  C. Fathman,et al.  Clones of alloreactive T cells , 1978, Nature.

[11]  H. Binz,et al.  Induction of specific transplantation immune reactions using anti- idiotypic antibodies , 1978, The Journal of experimental medicine.

[12]  A. Coutinho,et al.  Clonal Growth of T Cells in vitro: Preliminary Attempts to a Quantitative Approach , 1977, Immunological reviews.

[13]  C. Fathman,et al.  In vitro secondary mixed leukocyte reaction (MLR) , 1977, European journal of immunology.

[14]  G. Dennert,et al.  Continuously proliferating T killer cells specific for H-2b targets: selection and characterization. , 1976, Journal of immunology.

[15]  W. Paul,et al.  In vitro selection and extended culture of antigen-specific T lymphocytes. II. Mechanisms of selection. , 1975, Journal of immunology.

[16]  H. Macdonald,et al.  GENERATION OF CYTOTOXIC T LYMPHOCYTES IN VITRO , 1974, The Journal of experimental medicine.

[17]  C. Fathman,et al.  Clones of alloreactive T cells. I. A. unique homozygous MLR-stimulating determinant present on B6 stimulators. , 1980, Immunogenetics.

[18]  B. Benacerraf.  A hypothesis to relate the specificity of T lymphocytes and the activity of I region-specific Ir genes in macrophages and B lymphocytes. , 1978, Journal of immunology.

[19]  H. Binz,et al.  Antigen-binding, idiotypic receptors from T lymphocytes: an analysis of their biochemistry, genetics, and use as immunogens to produce specific immune tolerance. , 1977, Cold Spring Harbor symposia on quantitative biology.