Multifunctional cationic host defence peptides and their clinical applications

[1]  B. Nordén,et al.  Dual functions of the human antimicrobial peptide LL-37-target membrane perturbation and host cell cargo delivery. , 2010, Biochimica et biophysica acta.

[2]  Guangshun Wang,et al.  Antimicrobial peptides: discovery, design and novel therapeutic strategies. , 2010 .

[3]  R. Hancock,et al.  Cost-effective expression and purification of antimicrobial and host defense peptides in Escherichia coli , 2010, Peptides.

[4]  Eduardo Guaní-Guerra,et al.  Antimicrobial peptides: general overview and clinical implications in human health and disease. , 2010, Clinical immunology.

[5]  V. Torchilin,et al.  Intracellular transduction using cell-penetrating peptides. , 2010, Molecular bioSystems.

[6]  R. Hancock,et al.  Synthetic Cationic Peptide IDR-1002 Provides Protection against Bacterial Infections through Chemokine Induction and Enhanced Leukocyte Recruitment , 2010, The Journal of Immunology.

[7]  R. Rose CD-NP, a chimeric natriuretic peptide for the treatment of heart failure. , 2010, Current opinion in investigational drugs.

[8]  R. Hancock,et al.  Fine tuning host responses in the face of infection: Emerging roles and clinical applications of host defence peptides , 2010 .

[9]  T. Falla,et al.  Efficacy of hexapeptide-7 on menopausal skin. , 2010, Journal of drugs in dermatology : JDD.

[10]  R. Hancock,et al.  Therapeutic potential of HDPs as immunomodulatory agents. , 2010, Methods in molecular biology.

[11]  F. Schweizer,et al.  Cationic amphiphilic peptides with cancer-selective toxicity. , 2009, European journal of pharmacology.

[12]  P. Nibbering,et al.  Antimicrobial Peptide hLF1-11 Directs Granulocyte-Macrophage Colony-Stimulating Factor-Driven Monocyte Differentiation toward Macrophages with Enhanced Recognition and Clearance of Pathogens , 2009, Antimicrobial Agents and Chemotherapy.

[13]  A. Mor Multifunctional host defense peptides: antiparasitic activities , 2009, The FEBS journal.

[14]  M. Kesting,et al.  Host Defense Peptides as Effector Molecules of the Innate Immune Response: A Sledgehammer for Drug Resistance? , 2009, International journal of molecular sciences.

[15]  L. Foster,et al.  Intracellular Receptor for Human Host Defense Peptide LL-37 in Monocytes1 , 2009, The Journal of Immunology.

[16]  R. Hancock,et al.  Potential of immunomodulatory host defense peptides as novel anti-infectives , 2009, Trends in Biotechnology.

[17]  L. Babiuk,et al.  A novel vaccine adjuvant comprised of a synthetic innate defence regulator peptide and CpG oligonucleotide links innate and adaptive immunity. , 2009, Vaccine.

[18]  Shuang-quan Zhang,et al.  Production of a cytotoxic cationic antibacterial peptide in Escherichia coli using SUMO fusion partner , 2009, Applied Microbiology and Biotechnology.

[19]  R. Juliano,et al.  Cell-targeting and cell-penetrating peptides for delivery of therapeutic and imaging agents. , 2009, Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology.

[20]  L. Babiuk,et al.  CpG oligonucleotide, host defense peptide and polyphosphazene act synergistically, inducing long-lasting, balanced immune responses in cattle. , 2009, Vaccine.

[21]  M. Spielmann,et al.  Human beta‐defensin‐3 promotes wound healing in infected diabetic wounds , 2009, The journal of gene medicine.

[22]  B. Gowen,et al.  Killing of Trypanosomatid Parasites by a Modified Bovine Host Defense Peptide, BMAP-18 , 2009, PLoS neglected tropical diseases.

[23]  Artem Cherkasov,et al.  Use of artificial intelligence in the design of small peptide antibiotics effective against a broad spectrum of highly antibiotic-resistant superbugs. , 2009, ACS chemical biology.

[24]  R. Hancock,et al.  The roles of cathelicidin LL-37 in immune defences and novel clinical applications , 2009, Current opinion in hematology.

[25]  Benjamin A Lipsky,et al.  Topical versus systemic antimicrobial therapy for treating mildly infected diabetic foot ulcers: a randomized, controlled, double-blinded, multicenter trial of pexiganan cream. , 2008, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[26]  S. C. Kim,et al.  Mechanism of anticancer activity of buforin IIb, a histone H2A-derived peptide. , 2008, Cancer letters.

[27]  J. Burnett,et al.  Design, synthesis, and actions of a novel chimeric natriuretic peptide: CD-NP. , 2008, Journal of the American College of Cardiology.

[28]  J. Frøkiaer,et al.  AP214, an analogue of alpha-melanocyte-stimulating hormone, ameliorates sepsis-induced acute kidney injury and mortality. , 2008, Kidney international.

[29]  M. Kesting,et al.  Host Defense Peptides in Wound Healing , 2008, Molecular medicine.

[30]  B. Brandsdal,et al.  Antimicrobial peptides with stability toward tryptic degradation. , 2008, Biochemistry.

[31]  R. Hancock,et al.  Alternative mechanisms of action of cationic antimicrobial peptides on bacteria , 2007, Expert review of anti-infective therapy.

[32]  Oreola Donini,et al.  An anti-infective peptide that selectively modulates the innate immune response , 2007, Nature Biotechnology.

[33]  L. Babiuk,et al.  Innate immunity and new adjuvants. , 2007, Revue scientifique et technique.

[34]  R. Hancock,et al.  Cationic host defence peptides: Innate immune regulatory peptides as a novel approach for treating infections , 2007, Cellular and Molecular Life Sciences.

[35]  R. Hancock,et al.  Antimicrobial and host-defense peptides as new anti-infective therapeutic strategies , 2006, Nature Biotechnology.

[36]  R. Hancock,et al.  Antibacterial peptides for therapeutic use: obstacles and realistic outlook. , 2006, Current opinion in pharmacology.

[37]  T. S. Wilkinson,et al.  The human cationic host defense peptide LL‐37 mediates contrasting effects on apoptotic pathways in different primary cells of the innate immune system , 2006, Journal of leukocyte biology.

[38]  D. Hoskin,et al.  Cationic antimicrobial peptides as novel cytotoxic agents for cancer treatment , 2006, Expert opinion on investigational drugs.

[39]  R. Hancock,et al.  Peptide Antimicrobial Agents , 2006, Clinical Microbiology Reviews.

[40]  M. Zasloff Inducing endogenous antimicrobial peptides to battle infections. , 2006, Proceedings of the National Academy of Sciences of the United States of America.

[41]  R. Hancock,et al.  Host defence peptides from invertebrates--emerging antimicrobial strategies. , 2006, Immunobiology.

[42]  Vyacheslav Kalchenko,et al.  Inhibition of tumor growth and elimination of multiple metastases in human prostate and breast xenografts by systemic inoculation of a host defense-like lytic peptide. , 2006, Cancer research.

[43]  R. Hancock,et al.  Cationic host defense (antimicrobial) peptides. , 2006, Current opinion in immunology.

[44]  M. Ammendolia,et al.  Bovine lactoferrin peptidic fragments involved in inhibition of Echovirus 6 in vitro infection. , 2006, Antiviral research.

[45]  V. Nizet Antimicrobial peptide resistance mechanisms of human bacterial pathogens. , 2006, Current issues in molecular biology.

[46]  V. Nizet,et al.  Keratinocyte Production of Cathelicidin Provides Direct Activity against Bacterial Skin Pathogens , 2005, Infection and Immunity.

[47]  Glen R. Nemerow,et al.  Antiviral cyclic d,l-α-peptides: Targeting a general biochemical pathway in virus infections , 2005 .

[48]  C. Hawkey,et al.  Rdp58 Is a Novel and Potentially Effective Oral Therapy for Ulcerative Colitis , 2005, Inflammatory bowel diseases.

[49]  Robert E. W. Hancock,et al.  Antimicrobial Peptide Therapeutics for Cystic Fibrosis , 2005, Antimicrobial Agents and Chemotherapy.

[50]  F. Tangy,et al.  The antimicrobial peptide dermaseptin S4 inhibits HIV-1 infectivity in vitro. , 2005, Virology.

[51]  D. Davidson,et al.  Impact of LL‐37 on anti‐infective immunity , 2005, Journal of leukocyte biology.

[52]  Alessandro Tossi,et al.  Mammalian defensins: structures and mechanism of antibiotic activity , 2005, Journal of leukocyte biology.

[53]  K. Brogden Antimicrobial peptides: pore formers or metabolic inhibitors in bacteria? , 2005, Nature Reviews Microbiology.

[54]  Robert E W Hancock,et al.  A re-evaluation of the role of host defence peptides in mammalian immunity. , 2005, Current protein & peptide science.

[55]  G. Nemerow,et al.  Antiviral cyclic D,L-alpha-peptides: targeting a general biochemical pathway in virus infections. , 2005, Bioorganic & medicinal chemistry.

[56]  M. Cho,et al.  Pn-AMP1, a plant defense protein, induces actin depolarization in yeasts. , 2004, Plant & cell physiology.

[57]  R. Kaptein,et al.  The nisin–lipid II complex reveals a pyrophosphate cage that provides a blueprint for novel antibiotics , 2004, Nature Structural &Molecular Biology.

[58]  Y. Shai,et al.  Suppression of Human Prostate Tumor Growth in Mice by a Cytolytic d-, l-Amino Acid Peptide , 2004, Cancer Research.

[59]  Niv Papo,et al.  Effect of drastic sequence alteration and D-amino acid incorporation on the membrane binding behavior of lytic peptides. , 2004, Biochemistry.

[60]  Robert E. W. Hancock,et al.  Can innate immunity be enhanced to treat microbial infections? , 2004, Nature Reviews Microbiology.

[61]  K. Hahm,et al.  Antinematodal effect of antimicrobial peptide, PMAP‐23, isolated from porcine myeloid against Caenorhabditis elegans , 2004, Journal of peptide science : an official publication of the European Peptide Society.

[62]  E. Eklund,et al.  The Human Antimicrobial Peptide LL-37 Transfers Extracellular DNA Plasmid to the Nuclear Compartment of Mammalian Cells via Lipid Rafts and Proteoglycan-dependent Endocytosis* , 2004, Journal of Biological Chemistry.

[63]  D. Hoover,et al.  Multiple roles of antimicrobial defensins, cathelicidins, and eosinophil-derived neurotoxin in host defense. , 2004, Annual review of immunology.

[64]  A. Garden,et al.  A multinational, randomized phase III trial of iseganan HCl oral solution for reducing the severity of oral mucositis in patients receiving radiotherapy for head-and-neck malignancy. , 2004, International journal of radiation oncology, biology, physics.

[65]  R. Hancock,et al.  The Cationic Antimicrobial Peptide LL-37 Modulates Dendritic Cell Differentiation and Dendritic Cell-Induced T Cell Polarization , 2004, The Journal of Immunology.

[66]  R. Cunliffe,et al.  Expression and regulation of antimicrobial peptides in the gastrointestinal tract , 2004, Journal of leukocyte biology.

[67]  I. Nagaoka,et al.  Effect of antibacterial cathelicidin peptide CAP18/LL-37 on sepsis in neonatal rats , 2004, Pediatric Surgery International.

[68]  K. Rabe,et al.  The Antimicrobial Peptide LL-37 Activates Innate Immunity at the Airway Epithelial Surface by Transactivation of the Epidermal Growth Factor Receptor 1 , 2003, The Journal of Immunology.

[69]  M. Zasloff,et al.  Hagfish intestinal antimicrobial peptides are ancient cathelicidins , 2003, Peptides.

[70]  M. Coventry,et al.  The effect of bovine lactoferrin and lactoferricin B on the ability of feline calicivirus (a norovirus surrogate) and poliovirus to infect cell cultures , 2003, Journal of applied microbiology.

[71]  M. Weichenthal,et al.  Inducible and Constitutive &bgr;-Defensins Are Differentially Expressed in Crohn's Disease and Ulcerative Colitis , 2003, Inflammatory bowel diseases.

[72]  T. Ganz,et al.  Wound Healing and Expression of Antimicrobial Peptides/Polypeptides in Human Keratinocytes, a Consequence of Common Growth Factors1 , 2003, The Journal of Immunology.

[73]  S. Zahler,et al.  An angiogenic role for the human peptide antibiotic LL-37/hCAP-18. , 2003, The Journal of clinical investigation.

[74]  Dong-Kuk Lee,et al.  Mechanism of lipid bilayer disruption by the human antimicrobial peptide, LL-37. , 2003, Biochemistry.

[75]  A. Ramamoorthy,et al.  MSI-78, an analogue of the magainin antimicrobial peptides, disrupts lipid bilayer structure via positive curvature strain. , 2003, Biophysical journal.

[76]  N. Salzman,et al.  Protection against enteric salmonellosis in transgenic mice expressing a human intestinal defensin , 2003, Nature.

[77]  T. Waldmann,et al.  Immunotherapy: past, present and future , 2003, Nature Medicine.

[78]  J. M. Lipton,et al.  Novel α-melanocyte stimulating hormone peptide analogues with high candidacidal activity , 2003 .

[79]  J. M. Lipton,et al.  Novel alpha-melanocyte stimulating hormone peptide analogues with high candidacidal activity. , 2003, Journal of Medicinal Chemistry.

[80]  Göran Carlsson,et al.  Deficiency of antibacterial peptides in patients with morbus Kostmann: an observation study , 2002, The Lancet.

[81]  Tomas Ganz,et al.  Endogenous antimicrobial peptides and skin infections in atopic dermatitis. , 2002, The New England journal of medicine.

[82]  I. M. Belyakov,et al.  DNA vaccines encoding human immunodeficiency virus-1 glycoprotein 120 fusions with proinflammatory chemoattractants induce systemic and mucosal immune responses. , 2002, Blood.

[83]  L. Kwak,et al.  Mammalian defensins in immunity: more than just microbicidal. , 2002, Trends in immunology.

[84]  K. Iwabuchi,et al.  A cathelicidin family of human antibacterial peptide LL‐37 induces mast cell chemotaxis , 2002, Immunology.

[85]  K. Hahm,et al.  Design of novel peptide analogs with potent fungicidal activity, based on PMAP-23 antimicrobial peptide isolated from porcine myeloid. , 2002, Biochemical and biophysical research communications.

[86]  R. Hancock,et al.  Sublethal Concentrations of Pleurocidin-Derived Antimicrobial Peptides Inhibit Macromolecular Synthesis in Escherichia coli , 2002, Antimicrobial Agents and Chemotherapy.

[87]  M. Zasloff Antimicrobial peptides of multicellular organisms , 2002, Nature.

[88]  Takaaki Ohtake,et al.  Innate antimicrobial peptide protects the skin from invasive bacterial infection , 2001, Nature.

[89]  Y. Shai,et al.  From “carpet” mechanism to de-novo designed diastereomeric cell-selective antimicrobial peptides , 2001, Peptides.

[90]  R. Hancock,et al.  Cationic peptides: effectors in innate immunity and novel antimicrobials. , 2001, The Lancet. Infectious diseases.

[91]  R. Hancock,et al.  Interaction of Cationic Antimicrobial Peptides with Model Membranes* , 2001, The Journal of Biological Chemistry.

[92]  H. Schäfer,et al.  Human α-defensin 1 (HNP-1) inhibits adenoviral infection in vitro , 2001, Regulatory Peptides.

[93]  L. Yang,et al.  Barrel-stave model or toroidal model? A case study on melittin pores. , 2001, Biophysical journal.

[94]  V. Nizet,et al.  Cutaneous injury induces the release of cathelicidin anti-microbial peptides active against group A Streptococcus. , 2001, The Journal of investigative dermatology.

[95]  R. Hancock,et al.  Structure and Mechanism of Action of an Indolicidin Peptide Derivative with Improved Activity against Gram-positive Bacteria* , 2001, The Journal of Biological Chemistry.

[96]  I. Nagaoka,et al.  Evaluation of the effects of peptide antibiotics human β‐defensins‐1/‐2 and LL‐37 on histamine release and prostaglandin D2 production from mast cells , 2001 .

[97]  I. Nagaoka,et al.  Evaluation of the effects of peptide antibiotics human beta-defensins-1/-2 and LL-37 on histamine release and prostaglandin D(2) production from mast cells. , 2001, European journal of immunology.

[98]  H. Schäfer,et al.  Human alpha-defensin 1 (HNP-1) inhibits adenoviral infection in vitro. , 2001, Regulatory peptides.

[99]  Ji Ming Wang,et al.  Ll-37, the Neutrophil Granule–And Epithelial Cell–Derived Cathelicidin, Utilizes Formyl Peptide Receptor–Like 1 (Fprl1) as a Receptor to Chemoattract Human Peripheral Blood Neutrophils, Monocytes, and T Cells , 2000, The Journal of experimental medicine.

[100]  R. Hancock,et al.  The role of cationic antimicrobial peptides in innate host defences. , 2000, Trends in microbiology.

[101]  R. Hancock,et al.  The role of antimicrobial peptides in animal defenses. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[102]  R. Hancock,et al.  Antibacterial Action of Structurally Diverse Cationic Peptides on Gram-Positive Bacteria , 2000, Antimicrobial Agents and Chemotherapy.

[103]  Ji Ming Wang,et al.  Defensins act as potent adjuvants that promote cellular and humoral immune responses in mice to a lymphoma idiotype and carrier antigens. , 2000, International immunology.

[104]  James M. Wilson,et al.  Augmentation of Innate Host Defense by Expression of a Cathelicidin Antimicrobial Peptide , 1999, Infection and Immunity.

[105]  A. Singer,et al.  Cutaneous wound healing. , 1999, The New England journal of medicine.

[106]  M. Gilchrist,et al.  Neutrophil defensins induce histamine secretion from mast cells: mechanisms of action. , 1999, Journal of immunology.

[107]  E Maier,et al.  Mechanism of interaction of different classes of cationic antimicrobial peptides with planar bilayers and with the cytoplasmic membrane of Escherichia coli. , 1999, Biochemistry.

[108]  J. Lillard,et al.  Mechanisms for induction of acquired host immunity by neutrophil peptide defensins. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[109]  T. Walsh,et al.  Antifungal Peptides: Novel Therapeutic Compounds against Emerging Pathogens , 1999, Antimicrobial Agents and Chemotherapy.

[110]  X Zhang,et al.  A low-molecular-weight inhibitor against the chemokine receptor CXCR4: a strong anti-HIV peptide T140. , 1998, Biochemical and biophysical research communications.

[111]  C. B. Park,et al.  Mechanism of action of the antimicrobial peptide buforin II: buforin II kills microorganisms by penetrating the cell membrane and inhibiting cellular functions. , 1998, Biochemical and biophysical research communications.

[112]  C. Subbalakshmi,et al.  Mechanism of antimicrobial action of indolicidin. , 1998, FEMS microbiology letters.

[113]  K. Berndt,et al.  Conformation-dependent Antibacterial Activity of the Naturally Occurring Human Peptide LL-37* , 1998, The Journal of Biological Chemistry.

[114]  R. Hancock,et al.  Cationic peptides: a new source of antibiotics. , 1998, Trends in biotechnology.

[115]  N. Yoshida,et al.  A Small Molecule CXCR4 Inhibitor that Blocks T Cell Line–tropic HIV-1 Infection , 1997, The Journal of experimental medicine.

[116]  J. Fiddes,et al.  Protegrin-1: a broad-spectrum, rapidly microbicidal peptide with in vivo activity , 1997, Antimicrobial agents and chemotherapy.

[117]  G. Bondjers,et al.  Alternative splicing determines the binding of platelet-derived growth factor (PDGF-AA) to glycosaminoglycans. , 1996, Biochemistry.

[118]  N. Fujii,et al.  An antimicrobial peptide, magainin 2, induced rapid flip-flop of phospholipids coupled with pore formation and peptide translocation. , 1996, Biochemistry.

[119]  H. G. Boman,et al.  Mechanisms of action on Escherichia coli of cecropin P1 and PR-39, two antibacterial peptides from pig intestine , 1993, Infection and immunity.

[120]  Y. Shai,et al.  Interaction of antimicrobial dermaseptin and its fluorescently labeled analogues with phospholipid membranes. , 1992, Biochemistry.

[121]  J. D. Benson,et al.  Insulin-like growth factors I and II expression in the healing wound. , 1992, The Journal of surgical research.

[122]  T. Ganz,et al.  Interaction of human defensins with Escherichia coli. Mechanism of bactericidal activity. , 1989, The Journal of clinical investigation.

[123]  M J Banda,et al.  Wound macrophages express TGF-alpha and other growth factors in vivo: analysis by mRNA phenotyping. , 1988, Science.

[124]  J. Metcalf,et al.  Microbicidal/cytotoxic proteins of neutrophils are deficient in two disorders: Chediak-Higashi syndrome and "specific" granule deficiency. , 1988, The Journal of clinical investigation.

[125]  M. Zasloff,et al.  Magainins, a class of antimicrobial peptides from Xenopus skin: isolation, characterization of two active forms, and partial cDNA sequence of a precursor. , 1988, Proceedings of the National Academy of Sciences of the United States of America.

[126]  M. Zasloff,et al.  Magainins, a class of antimicrobial peptides from Xenopus skin: isolation, characterization of two active forms, and partial cDNA sequence of a precursor , 1987 .

[127]  T. Ganz,et al.  Correlation of binding of rabbit granulocyte peptides to Candida albicans with candidacidal activity , 1985, Infection and immunity.

[128]  H Lecar,et al.  Electrically gated ionic channels in lipid bilayers , 1977, Quarterly Reviews of Biophysics.