Synthesis of some 7‐substituted‐2,4,8(1H,3H,7H)pyrimido[5,4‐d]pyrimidinetriones

A synthesis of 2,4,8-pyrimido[5,4-d]pyrimidinetriones under mild conditions from ethyl 5-ethoxymethyleneamino-orotate allows the introduction of a variety of substituents regiospecifically into the 7-position. The 7-methyl and 7-benzyl derivatives were methylated with trimethyl phosphate to the 1,3,7-trialkyl derivatives.

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