A case of fetus in fetu.

explanation of this discrepancy may be that the child was hypersensitive to quinine. However, exchange transfusion, which is the logical method oftreatment, produced both a dramatic improvement in the child's clinical condition and a fall in plasma quinine concentrations. Quinine does not readily cross the blood-brain barrier (Goodman and Gilman, 1970), but in the present case the concentration of quinine in the CSF was about 35% of that in the plasma. It is generally thought that quinine has a direct toxic action on the retina which may take months to recover. In the present case it is of interest that, though the child was initially both deaf and blind, she recovered both faculties within 5 days.