Formulation of effects of atropine, pralidoxime and magnesium sulfate on cardiac tissue levels of nitric oxide, malondialdehyde and glutathione in organophosphate poisoning using artificial neural network

Anticholinesterase poisoning is an important health problem in our country, and a complete understanding of its underlying mechanisms is essential for the emergency physician. So, this study focused on two purposes. First one was aimed to investigate the biochemical analysis to determine the tissue levels of malondialdehyde (MDA), glutathione and nitric oxide (NO). Secondly, it was planned to model and formulate the effects of some drugs on cardiac tissues levels of NO, MDA and glutathione in acute organophosphate poisoning in rats by the application of neural network based on experimental results. It has been planned to determine whether artificial neural network (ANN) is appropriate tool to analyze and formulate it. As a result, it has been considered that ANN can be effectively used to model NO, MDA and glutathione level. The performances of ANN formulation versus target experimental values are found to be quite high. It is concluded that, proposed NN models are also presented as simple explicit mathematical functions for further use by researchers.

[1]  Mustafa Canakci,et al.  Performance and exhaust emissions of a gasoline engine using artificial neural network , 2007 .

[2]  Simon Haykin,et al.  Neural Networks: A Comprehensive Foundation , 1998 .

[3]  James L. McClelland,et al.  Parallel distributed processing: explorations in the microstructure of cognition, vol. 1: foundations , 1986 .

[4]  Geoffrey E. Hinton,et al.  Learning internal representations by error propagation , 1986 .

[5]  K. Yagi,et al.  Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. , 1979, Analytical biochemistry.

[6]  T. Kwong,et al.  Organophosphate Pesticides: Biochemistry and Clinical Toxicology , 2002, Therapeutic drug monitoring.

[7]  C. Napolitano,et al.  Torsade de Pointes , 2012, Drugs.

[8]  Al-Ali,et al.  Cardiac manifestations of acute carbamate and organophosphate poisoning. , 1997, Heart.

[9]  L. Karalliedde.  Organophosphorus poisoning and anaesthesia , 1999, Anaesthesia.

[10]  E. Kaplinsky,et al.  Q-T prolongation and polymorphous ("torsade de pointes") ventricular arrhythmias associated with organophosphorus insecticide poisoning. , 1982, The American journal of cardiology.

[11]  A. Maisel,et al.  Polymorphic ventricular tachycardia and other complex arrhythmias in organophosphate insecticide poisoning. , 1984, Journal of electrocardiology.

[12]  M. Sungur,et al.  Intensive care management of organophosphate insecticide poisoning , 2001, Critical care.

[13]  M. Arad,et al.  Organophosphates and the heart. , 1993, Chest.

[14]  Erdoğan Kanca,et al.  Prediction of martensite and austenite start temperatures of the Fe-based shape memory alloys by artificial neural networks , 2008 .

[15]  P. Karki,et al.  Cardiac and electrocardiographical manifestations of acute organophosphate poisoning. , 2004, Singapore medical journal.

[16]  Ming-Hsi Wang,et al.  Q-T interval prolongation and pleomorphic ventricular tachyarrhythmia (`Torsade de pointes') in organophosphate poisoning: report of a case , 1998, Human & experimental toxicology.

[17]  B. Alaşehirli,et al.  No evidence for an association between the Glu298Asp polymorphism of the endothelial nitric oxide synthase gene and fibromyalgia syndrome , 2006, Rheumatology International.

[18]  E. Odacı,et al.  Oral erdosteine administration attenuates cisplatin-induced renal tubular damage in rats. , 2003, Pharmacological research.

[19]  C. Yıldırım,et al.  Cardiac damage in acute organophosphate poisoning in rats: effects of atropine and pralidoxime. , 2009, The American journal of emergency medicine.

[20]  N. Delibaş,et al.  Cardiotoxicity in rats induced by methidathion and ameliorating effect of vitamins E and C , 2004, Human & experimental toxicology.

[21]  E. Bar-Meir,et al.  Early onset of ventricular tachyarrhythmias in organophosphate intoxication. , 2002, The Israel Medical Association journal : IMAJ.

[22]  Soteris A. Kalogirou,et al.  Artificial intelligence for the modeling and control of combustion processes: a review , 2003 .

[23]  D. Bagchi,et al.  In vitro and in vivo generation of reactive oxygen species, DNA damage and lactate dehydrogenase leakage by selected pesticides. , 1995, Toxicology.