Structure-Function Relationships to Guide Rational Design and Fabrication of Particulate Food Delivery Systems

The rational design and fabrication of food-grade delivery systems can draw extensively from the knowledge gained through the development of drug delivery systems. This review provides a concise overview of particulate delivery systems and outlines current research trends linking their structural properties to their functionality, e.g., matrix compatibility, stability, release characteristics and bioavailability. The need to establish quantitative structure–function relationships (QSFR) between particle properties and delivery system functionality is highlighted for the efficient development of food-grade delivery systems in the future.

[1]  G. Macfarlane,et al.  Validation of a Three-Stage Compound Continuous Culture System for Investigating the Effect of Retention Time on the Ecology and Metabolism of Bacteria in the Human Colon , 1998, Microbial Ecology.

[2]  D. Mcclements,et al.  Effect of interfacial protein cross-linking on the in vitro digestibility of emulsified corn oil by pancreatic lipase. , 2008, Journal of agricultural and food chemistry.

[3]  P. Sanguansri,et al.  Impact of oil type on nanoemulsion formation and Ostwald ripening stability. , 2008, Langmuir : the ACS journal of surfaces and colloids.

[4]  D. Lairon,et al.  Emulsions et absorption des lipides : Importance des propriétés physicochimiques : Lipides, nutrition et science de l'aliment , 1997 .

[5]  Siyeon Rhee,et al.  Influence of encapsulation of emulsified lipids with chitosan on their in vivo digestibility , 2007 .

[6]  H. Brøndsted,et al.  Current applications of polysaccharides in colon targeting. , 1996, Critical reviews in therapeutic drug carrier systems.

[7]  Philippe Marteau,et al.  A Multicompartmental Dynamic Computer-controlled Model Simulating the Stomach and Small Intestine , 1995 .

[8]  L. Sanguansri,et al.  NMR of Microencapsulated Fish Oil Samples During In Vitro Digestion , 2009 .

[9]  J. Groten,et al.  Toxicological evaluation of chemical mixtures. , 2002, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

[10]  G. Gibson,et al.  Effects of resistant starch type III polymorphs on human colon microbiota and short chain fatty acids in human gut models. , 2008, Journal of agricultural and food chemistry.

[11]  D. Mcclements.  Theoretical prediction of emulsion color. , 2002, Advances in colloid and interface science.

[12]  C. Barrow,et al.  Stabilization of highly unsaturated fatty acids and delivery into foods , 2007 .

[13]  H. Mu.  Bioavailability of omega-3 long-chain polyunsaturated fatty acids from foods , 2008 .

[14]  T. Howes,et al.  Hydrocolloid Gel Particles: Formation, Characterization, and Application , 2008, Critical reviews in food science and nutrition.

[15]  D. Lairon,et al.  Digestion and absorption of 2 fat emulsions with different droplet sizes in the human digestive tract. , 1999, The American journal of clinical nutrition.

[16]  A. Beynen,et al.  The concept of iron bioavailability and its assessment , 1999, European journal of nutrition.

[17]  Mary Ann Augustin,et al.  Nano- and micro-structured assemblies for encapsulation of food ingredients. , 2009, Chemical Society reviews.

[18]  J. Weiss,et al.  Liposomal Nanocapsules in Food Science and Agriculture , 2005, Critical reviews in food science and nutrition.

[19]  E. Shimoni,et al.  Effects of long chain fatty acid unsaturation on the structure and controlled release properties of amylose complexes , 2009 .

[20]  R. J. Hunter,et al.  The sedimentation behaviour of coagulated particles of small radius , 1986 .

[21]  D. Mcclements,et al.  Emulsion-based delivery systems for lipophilic bioactive components. , 2007, Journal of food science.

[22]  D. Mcclements.  Understanding and Controlling the Microstructure of Complex Foods , 2007 .

[23]  S. Hill,et al.  Aroma permeability of hydroxypropyl maize starch films. , 2009, Journal of agricultural and food chemistry.

[24]  E. Shimoni,et al.  Utilization of amylose-lipid complexes as molecular nanocapsules for conjugated linoleic Acid. , 2005, Biomacromolecules.

[25]  N. Garti,et al.  Protein-Polysaccharide Interactions for Stabilization of Food Emulsions , 2002 .

[26]  H. Bouwmeester,et al.  A review of analytical methods for the identification and characterization of nano delivery systems in food. , 2008, Journal of agricultural and food chemistry.

[27]  S. Kosaraju.  Colon Targeted Delivery Systems: Review of Polysaccharides for Encapsulation and Delivery , 2005, Critical reviews in food science and nutrition.

[28]  E. Shimoni,et al.  Continuous dual feed homogenization for the production of starch inclusion complexes for controlled release of nutrients , 2008 .

[29]  G. Gibson,et al.  Metabolism of Maillard reaction products by the human gut microbiota--implications for health. , 2006, Molecular nutrition & food research.

[30]  M. Subirade,et al.  Food protein-based materials as nutraceutical delivery systems , 2006 .

[31]  D. Lairon,et al.  Emulsion and absorption of lipids: the importance of physicochemical properties , 1997 .

[32]  Xiao Dong Chen,et al.  GIT Physicochemical Modeling - A Critical Review , 2006 .

[33]  E. Pelan,et al.  Colloidal delivery systems for micronutrients and nutraceuticals , 2008 .

[34]  H. Bianco-Peled,et al.  Studying different dimensions of amylose-long chain fatty acid complexes: Molecular, nano and micro level characteristics , 2009 .

[35]  D. Mcclements,et al.  Controlling Lipid Bioavailability through Physicochemical and Structural Approaches , 2008, Critical reviews in food science and nutrition.

[36]  David Julian McClements,et al.  Food Emulsions: Principles, Practice, and Techniques , 1998 .

[37]  C. Porter,et al.  Lipids and lipid-based formulations: optimizing the oral delivery of lipophilic drugs , 2007, Nature Reviews Drug Discovery.

[38]  Yangang Liu,et al.  Relationship of refractive index to mass density and self-consistency of mixing rules for multicomponent mixtures like ambient aerosols , 2008 .

[39]  Sir,et al.  Development and applicability of an in vitro digestionmodel in assessing the bioaccessibility of contaminants from food , 2004 .

[40]  J. Dressman,et al.  Influence of physicochemical properties on dissolution of drugs in the gastrointestinal tract. , 1997, Advanced drug delivery reviews.

[41]  D. Mcclements,et al.  Designing Food Structure to Control Stability, Digestion, Release and Absorption of Lipophilic Food Components , 2008 .

[42]  J. Siepmann,et al.  Mathematical modeling of drug delivery. , 2008, International journal of pharmaceutics.

[43]  Gustavo V. Barbosa-Cánovas,et al.  Fundamental aspects of controlled release in foods , 1995 .

[44]  G. V. Aken,et al.  17 – Relating food microstructure to sensory quality , 2007 .

[45]  D. Mcclements,et al.  Influence of Interfacial Composition on in Vitro Digestibility of Emulsified Lipids: Potential Mechanism for Chitosan's Ability to Inhibit Fat Digestion , 2006 .

[46]  R. Mezzenga,et al.  Food structure and functionality: a soft matter perspective. , 2008, Soft matter.

[47]  W. Verstraete,et al.  Validation of the Simulator of the Human Intestinal Microbial Ecosystem (SHIME) Reactor Using Microorganism-associated Activities , 1994 .

[48]  D. Lairon,et al.  Effects of droplet size, triacylglycerol composition, and calcium on the hydrolysis of complex emulsions by pancreatic lipase : an in vitro study , 1992 .

[49]  J. Aguilera,et al.  Food microstructure affects the bioavailability of several nutrients. , 2007, Journal of food science.