Multi-layer Perceptrons with Embedded Feature Selection with Application in Cancer Classification ∗

∗ This research was supported by the National Natural Science Foundation of China under Grant No. 60372050. Abstract — This paper proposed a novel neural network model, named multi-layer perceptrons with embedded feature selection (MLPs-EFS), where feature selection is incorporated into the training procedure. Compared with the classical MLPs, MLPs-EFS add a preprocessing step where each feature of the samples is multiplied by the corresponding scaling factor. By applying a truncated Laplace prior to the scaling factors, feature selection is integrated as a part of MLPs-EFS. Moreover, a variant of MLPs-EFS, named EFS+MLPs is also given, which perform feature selection more flexibly. Application in cancer classification validates the effectiveness of the proposed algorithms.

[1]  Guoqiang Peter Zhang,et al.  Neural networks for classification: a survey , 2000, IEEE Trans. Syst. Man Cybern. Part C.

[2]  R. Tibshirani Regression Shrinkage and Selection via the Lasso , 1996 .

[3]  Shoujue Wang,et al.  A More Complex Neuron in Biomimetic Pattern Recognition , 2005, 2005 International Conference on Neural Networks and Brain.

[4]  Deniz Erdogmus,et al.  Feature selection in MLPs and SVMs based on maximum output information , 2004, IEEE Transactions on Neural Networks.

[5]  Pat Langley,et al.  Selection of Relevant Features and Examples in Machine Learning , 1997, Artif. Intell..

[6]  Huan Liu,et al.  Neural-network feature selector , 1997, IEEE Trans. Neural Networks.

[7]  Licheng Jiao,et al.  Feature Scaling for Kernel Fisher Discriminant Analysis Using Leave-One-Out Cross Validation , 2006, Neural Computation.

[8]  Chun-Nan Hsu,et al.  The ANNIGMA-wrapper approach to fast feature selection for neural nets , 2002, IEEE Trans. Syst. Man Cybern. Part B.