Semen collection from young cancer patients

The Annual Meeting of the British Andrology Society held in Bristol in October 2000 included a short symposium of invited speakers to address some of the increasingly difficult dilemmas encountered by doctors who deal with young boys undergoing treatments that are likely to render them sterile. Public awareness in this area is growing and, increasingly, young boys undergoing such treatments, and their parents, are requesting sperm storage. The first speaker at the symposium was Dr Helen Kershaw who works as a clinician in the field of paediatric oncology. She set the scene by explaining the incidence of childhood cancer, the treatments available, survival rates and the urgent time frame in which oncologists must work. Dr Catherine Coulson, who gave the second talk, works as a clinician in the field of reproductive medicine and has experience of counselling boys and their parents before attempting to store sperm. She explained some of the difficulties encountered and raised the question of whether storing sperm was always justified. The third speaker was Dr John Radford who works as an oncologist and has conducted research into the uptake and use of stored sperm. He has researched the possibility of storing germ cells before sterilizing treatment for Hodgkin and non-Hodgkin lymphoma, and injection of the cryopreserved germ cells into the testes after treatment. Dr Victor Larcher, who works as a paediatrician and has an interest in ethics and the law, gave the final talk. He explored some of the ethical issues surrounding sperm storage generally and issues of consent in children in particular. Discussion was lively and raised the question of who should provide counselling in such cases and for how long. The need to provide an urgent service and yet provide information that is easily understandable so that truly informed consent is obtained is clearly taxing those working in the field.

[1]  W. Wallace,et al.  Fertility preservation for children treated for cancer (1): scientific advances and research dilemmas , 2001, Archives of disease in childhood.

[2]  W. Wallace,et al.  Fertility preservation for children treated for cancer (2): ethics of consent for gamete storage and experimentation , 2001, Archives of disease in childhood.

[3]  J. Radford,et al.  Isolation of germ cells from human testicular tissue for low temperature storage and autotransplantation. , 2001, Fertility and sterility.

[4]  A. Agarwal,et al.  Cryopreservation of Gametes in Young Patients With Cancer , 1998, Journal of pediatric hematology/oncology.

[5]  G. Koren,et al.  Empirical examination of the ability of children to consent to clinical research. , 1998, Journal of medical ethics.

[6]  R. Brinster,et al.  Reconstitution of spermatogenesis from frozen spermatogonial stem cells , 1996, Nature Medicine.

[7]  R. Brinster,et al.  Germline transmission of donor haplotype following spermatogonial transplantation. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[8]  R. Brinster,et al.  Spermatogenesis following male germ-cell transplantation. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[9]  R. Hautmann,et al.  Reproductive toxicity with and without LHRHA administration during adjuvant chemotherapy in patients with germ cell tumors. , 1990, Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme.

[10]  J. A. Ward,et al.  Protection of spermatogenesis in rats from the cytotoxic procarbazine by the depot formulation of Zoladex, a gonadotropin-releasing hormone agonist. , 1990, Cancer research.

[11]  G. Clayden Medical Research with Children: Ethics, Law and Practice , 1986 .

[12]  J. Hainsworth,et al.  Effect of a luteinizing hormone releasing hormone agonist given during combination chemotherapy on posttherapy fertility in male patients with lymphoma: preliminary observations , 1985 .

[13]  R. Brinster,et al.  Transplantation of male germ line stem cells restores fertility in infertile mice , 2000, Nature Medicine.

[14]  Politika tudományok Human Fertilisation and Embryology Act 1990. , 1990, Halsbury's statutes of England. Great Britain.

[15]  S. Gollamudi Medical Research with Children: Ethics, Law and Practice , 1987, The Yale Journal of Biology and Medicine.