Advances in Molecular and Cellular Therapies for Hearing Loss.

[1]  Donald L. Swiderski,et al.  Cochlear implants and ex vivo BDNF gene therapy protect spiral ganglion neurons , 2007, Hearing Research.

[2]  Mark A Behlke,et al.  Design of active small interfering RNAs. , 2007, Current opinion in molecular therapeutics.

[3]  E. Yumoto,et al.  Dan is required for normal morphogenesis and patterning in the developing chick inner ear , 2007, Development, growth & differentiation.

[4]  J. Ito,et al.  Cell-gene delivery of brain-derived neurotrophic factor to the mouse inner ear. , 2006, Molecular therapy : the journal of the American Society of Gene Therapy.

[5]  Huawei Li,et al.  Engraftment and differentiation of embryonic stem cell-derived neural progenitor cells in the cochlear nerve trunk: growth of processes into the organ of Corti. , 2006, Journal of neurobiology.

[6]  V. Hornung,et al.  siRNA and isRNA: two edges of one sword. , 2006, Molecular therapy : the journal of the American Society of Gene Therapy.

[7]  Channy Park,et al.  Flunarizine induces Nrf2-mediated transcriptional activation of heme oxygenase-1 in protection of auditory cells from cisplatin , 2006, Cell Death and Differentiation.

[8]  T. Tuschl,et al.  On the art of identifying effective and specific siRNAs , 2006, Nature Methods.

[9]  R. Samulski,et al.  Adeno-associated virus serotypes: vector toolkit for human gene therapy. , 2006, Molecular therapy : the journal of the American Society of Gene Therapy.

[10]  J. Bennett,et al.  In vivo delivery of recombinant viruses to the fetal murine cochlea: transduction characteristics and long-term effects on auditory function. , 2006, Molecular therapy : the journal of the American Society of Gene Therapy.

[11]  R. Miyamoto,et al.  In Vivo and In Vitro Characterization of Bone Marrow‐Derived Stem Cells in the Cochlea , 2006, The Laryngoscope.

[12]  J. Schelter,et al.  Designing siRNA That Distinguish between Genes That Differ by a Single Nucleotide , 2006, PLoS genetics.

[13]  B. Cullen.  Is RNA interference involved in intrinsic antiviral immunity in mammals? , 2006, Nature Immunology.

[14]  Jae-Hyung Lee,et al.  Heme oxygenase-1 attenuates the cisplatin-induced apoptosis of auditory cells via down-regulation of reactive oxygen species generation. , 2006, Free radical biology & medicine.

[15]  R. A. Schmiedt,et al.  Contribution of bone marrow hematopoietic stem cells to adult mouse inner ear: Mesenchymal cells and fibrocytes , 2006, The Journal of comparative neurology.

[16]  Stephanie B. Epp,et al.  Fate of Embryonic Stem Cells Transplanted into the Deafened Mammalian Cochlea , 2006, Cell transplantation.

[17]  Y. Raphael,et al.  Transgene correction maintains normal cochlear structure and function in 6-month-old Myo15a mutant mice , 2006, Hearing Research.

[18]  J. Ito,et al.  Cell transplantation to the auditory nerve and cochlear duct , 2006, Experimental Neurology.

[19]  A. Lee,et al.  Design of noninflammatory synthetic siRNA mediating potent gene silencing in vivo. , 2006, Molecular therapy : the journal of the American Society of Gene Therapy.

[20]  C. Petit.  From deafness genes to hearing mechanisms: harmony and counterpoint. , 2006, Trends in molecular medicine.

[21]  Youping Deng,et al.  Glucocorticoid regulation of genes in the amiloride-sensitive sodium transport pathway by semicircular canal duct epithelium of neonatal rat. , 2006, Physiological genomics.

[22]  J. Ito,et al.  Engraftment of embryonic stem cell-derived neurons into the cochlear modiolus , 2005, Neuroreport.

[23]  H. Paulson,et al.  Silencing Primary Dystonia: Lentiviral-Mediated RNA Interference Therapy for DYT1 Dystonia , 2005, The Journal of Neuroscience.

[24]  B. Williams,et al.  Activation of the mammalian immune system by siRNAs , 2005, Nature Biotechnology.

[25]  R. Shepherd,et al.  Survival of Partially Differentiated Mouse Embryonic Stem Cells in the Scala Media of the Guinea Pig Cochlea , 2005, Journal of the Association for Research in Otolaryngology.

[26]  H. Mizukami,et al.  Specific and efficient transduction of Cochlear inner hair cells with recombinant adeno-associated virus type 3 vector. , 2005, Molecular therapy : the journal of the American Society of Gene Therapy.

[27]  Richard J. H. Smith,et al.  In vitro and in vivo suppression of GJB2 expression by RNA interference. , 2005, Human molecular genetics.

[28]  D. Ganem,et al.  A Virus-Encoded Inhibitor That Blocks RNA Interference in Mammalian Cells , 2005, Journal of Virology.

[29]  M. Salminen,et al.  Xenografted fetal dorsal root ganglion, embryonic stem cell and adult neural stem cell survival following implantation into the adult vestibulocochlear nerve , 2005, Experimental Neurology.

[30]  S. Le,et al.  Evidence that HIV-1 encodes an siRNA and a suppressor of RNA silencing. , 2005, Immunity.

[31]  Claes Wahlestedt,et al.  A systematic analysis of the silencing effects of an active siRNA at all single-nucleotide mismatched target sites , 2005, Nucleic acids research.

[32]  J. Bale,et al.  Sensorineural hearing loss in children , 2005, The Lancet.

[33]  Ryosei Minoda,et al.  Auditory hair cell replacement and hearing improvement by Atoh1 gene therapy in deaf mammals , 2005, Nature Medicine.

[34]  Jonathan D. Smith,et al.  Expression of the carrier protein apolipoprotein D in the mouse inner ear , 2005, Hearing Research.

[35]  M. Ulfendahl,et al.  NGF stimulates extensive neurite outgrowth from implanted dorsal root ganglion neurons following transplantation into the adult rat inner ear , 2005, Neurobiology of Disease.

[36]  M. Montcouquiol,et al.  Math1 regulates development of the sensory epithelium in the mammalian cochlea , 2004, Nature Neuroscience.

[37]  M. Ulfendahl,et al.  Central migration of neuronal tissue and embryonic stem cells following transplantation along the adult auditory nerve , 2004, Brain Research.

[38]  V. Ambros.  The functions of animal microRNAs , 2004, Nature.

[39]  Phillip A. Sharp,et al.  The RNAi revolution , 2004, Nature.

[40]  K. Kawamoto,et al.  Adenovirus-Mediated Expression of Brain-Derived Neurotrophic Factor Protects Spiral Ganglion Neurons from Ototoxic Damage , 2004, Audiology and Neurotology.

[41]  Zhong-yan Liu,et al.  Morphology of auditory hair cells in guinea pig cochlea after transgene expression , 2004, Hearing Research.

[42]  Shunli Liu,et al.  [Protection of NT3 gene transfection on the guinea pig cochlea treated with gentamicin]. , 2004, Lin chuang er bi yan hou ke za zhi = Journal of clinical otorhinolaryngology.

[43]  K. Omori,et al.  Transplantation of neural stem cells into the modiolus of mouse cochleae injured by cisplatin. , 2004, Acta oto-laryngologica. Supplementum.

[44]  Y. Sasai,et al.  Fates of mouse embryonic stem cells transplanted into the inner ears of adult mice and embryonic chickens. , 2004, Acta oto-laryngologica. Supplementum.

[45]  J. Ito,et al.  Survival of fetal Rat otocyst cells grafted into the damaged inner ear , 2004, Acta oto-laryngologica. Supplementum.

[46]  K. Kawamoto,et al.  Antioxidant gene therapy can protect hearing and hair cells from ototoxicity. , 2004, Molecular therapy : the journal of the American Society of Gene Therapy.

[47]  Tatsuo Nakamura,et al.  Transplantation of bone marrow stromal cells into the cochlea of chinchillas , 2004, Neuroreport.

[48]  Y. Kaneda,et al.  Intrathecal injection of HVJ‐E containing HGF gene to cerebrospinal fluid can prevent and ameliorate hearing impairment in rats , 2004, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[49]  James O. Pickles,et al.  Mutation in Mitochondrial DNA as a Cause of Presbyacusis , 2003, Audiology and Neurotology.

[50]  M. Ulfendahl,et al.  Survival of neuronal tissue following xenograft implantation into the adult rat inner ear , 2003, Experimental Neurology.

[51]  R. Kageyama,et al.  Fate of neural stem cells grafted into injured inner ears of mice , 2003, Neuroreport.

[52]  Z. Estrov,et al.  Adult stem cells for tissue repair - a new therapeutic concept? , 2003, The New England journal of medicine.

[53]  P. Zamore,et al.  Selective silencing by RNAi of a dominant allele that causes amyotrophic lateral sclerosis , 2003, Aging cell.

[54]  D. Bagger-sjöbäck,et al.  Allografted fetal dorsal root ganglion neuronal survival in the guinea pig cochlea , 2003, Brain Research.

[55]  M. I. Lomax,et al.  Pathways for protection from noise induced hearing loss. , 2003, Noise & health.

[56]  Haibin Xia,et al.  Allele-specific silencing of dominant disease genes , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[57]  K. Kawamoto,et al.  Math1 Gene Transfer Generates New Cochlear Hair Cells in Mature Guinea Pigs In Vivo , 2003, The Journal of Neuroscience.

[58]  D. Orlic.  Adult Bone Marrow Stem Cells Regenerate Myocardium in Ischemic Heart Disease , 2003, Annals of the New York Academy of Sciences.

[59]  Toshimitsu Kobayashi,et al.  Transgenic expression of a dominant-negative connexin26 causes degeneration of the organ of Corti and non-syndromic deafness. , 2003, Human molecular genetics.

[60]  Paul G Shekelle,et al.  Screening and management of adult hearing loss in primary care: clinical applications. , 2003, JAMA.

[61]  F. Natt,et al.  Independent combinatorial effect of antisense oligonucleotides and RNAi-mediated specific inhibition of the recombinant rat P2X3 receptor. , 2003, Nucleic acids research.

[62]  J. Vermeesch,et al.  Skeletal muscle repair by adult human mesenchymal stem cells from synovial membrane , 2003, The Journal of cell biology.

[63]  C. F. Bennett,et al.  Efficient Reduction of Target RNAs by Small Interfering RNA and RNase H-dependent Antisense Agents , 2003, The Journal of Biological Chemistry.

[64]  J. Ito,et al.  Trophic support of mouse inner ear by neural stem cell transplantation , 2003, Neuroreport.

[65]  R. Bernards,et al.  Stable suppression of tumorigenicity by virus-mediated RNA interference. , 2002, Cancer cell.

[66]  J. Polak,et al.  Stem cells: sources and applications. , 2002, Clinical otolaryngology and allied sciences.

[67]  G. Daley,et al.  Correction of a Genetic Defect by Nuclear Transplantation and Combined Cell and Gene Therapy , 2002, Cell.

[68]  Bruce G. Jenkins,et al.  Embryonic stem cells develop into functional dopaminergic neurons after transplantation in a Parkinson rat model , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[69]  H. Ishikawa,et al.  New approach for the establishment of mouse early embryonic stem cells and induction of their differentiation. , 2001, Human cell.

[70]  A. Summerfield,et al.  Prevalence of permanent childhood hearing impairment in the United Kingdom and implications for universal neonatal hearing screening: questionnaire based ascertainment study. , 2001, BMJ : British Medical Journal.

[71]  S. Ikehara,et al.  Prevention of accelerated presbycusis by bone marrow transplantation in senescence-accelerated mice , 2001, Bone Marrow Transplantation.

[72]  F. Martinez,et al.  Drug-induced Otoxicity: Current Status , 2001 .

[73]  M. Entman,et al.  Regeneration of ischemic cardiac muscle and vascular endothelium by adult stem cells. , 2001, The Journal of clinical investigation.

[74]  J. Weiler,et al.  Specific inhibition of the rat ligand-gated ion channel P2X3 function via methoxyethoxy-modified phosphorothioated antisense oligonucleotides. , 2001, Antisense & nucleic acid drug development.

[75]  T. Tuschl,et al.  Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells , 2001, Nature.

[76]  K. Sugaya,et al.  Human neural stem cells improve cognitive function of aged brain , 2001, Neuroreport.

[77]  A. Peel,et al.  Cochlear function and transgene expression in the guinea pig cochlea, using adenovirus- and adeno-associated virus-directed gene transfer. , 2001, Human gene therapy.

[78]  M. Hansen,et al.  Multiple Distinct Signal Pathways, Including an Autocrine Neurotrophic Mechanism, Contribute to the Survival-Promoting Effect of Depolarization on Spiral Ganglion Neurons In Vitro , 2001, The Journal of Neuroscience.

[79]  A. Lalwani,et al.  Cochlear gene delivery through an intact round window membrane in mouse. , 2001, Human gene therapy.

[80]  Anil K. Lalwani,et al.  A surgical approach appropriate for targeted cochlear gene therapy in the mouse , 2001, Hearing Research.

[81]  T. Tuschl,et al.  RNA interference is mediated by 21- and 22-nucleotide RNAs. , 2001, Genes & development.

[82]  Sho Kanzaki,et al.  Spiral Ganglion Neurons Are Protected from Degeneration by GDNF Gene Therapy , 2000, Journal of the Association for Research in Otolaryngology.

[83]  O. Danos,et al.  Canine Adenovirus Type 2 Attachment and Internalization: Coxsackievirus-Adenovirus Receptor, Alternative Receptors, and an RGD-Independent Pathway , 2000, Journal of Virology.

[84]  Steven D. Carson.  Limited proteolysis of the coxsackievirus and adenovirus receptor (CAR) on HeLa cells exposed to trypsin , 2000, FEBS letters.

[85]  A. Lalwani,et al.  Cochlear microinjection and its effects upon auditory function in the guinea pig , 2000, European Archives of Oto-Rhino-Laryngology.

[86]  A. Lalwani,et al.  Safety of adeno-associated virus as cochlear gene transfer vector: analysis of distant spread beyond injected cochleae. , 2000, Molecular therapy : the journal of the American Society of Gene Therapy.

[87]  L. Naldini,et al.  Lentiviral vectors: excellent tools for experimental gene transfer and promising candidates for gene therapy , 2000, The journal of gene medicine.

[88]  Jian Wang,et al.  Auditory plasticity and hyperactivity following cochlear damage , 2000, Hearing Research.

[89]  W. Gao,et al.  Overexpression of Math1 induces robust production of extra hair cells in postnatal rat inner ears , 2000, Nature Neuroscience.

[90]  J. Qiu,et al.  The interaction of heparin sulfate and adeno-associated virus 2. , 2000, Virology.

[91]  W. Arnold,et al.  Successful Treatment of Noise‐Induced Cochlear Ischemia, Hypoxia, and Hearing Loss , 1999, Annals of the New York Academy of Sciences.

[92]  X. Estivill,et al.  Mutations in GJB6 cause nonsyndromic autosomal dominant deafness at DFNA3 locus , 1999, Nature Genetics.

[93]  J. Gray,et al.  Prospects for the clinical application of neural transplantation with the use of conditionally immortalized neuroepithelial stem cells. , 1999, Philosophical transactions of the Royal Society of London. Series B, Biological sciences.

[94]  D. Trono,et al.  Transgene expression in the guinea pig cochlea mediated by a lentivirus-derived gene transfer vector. , 1999, Human gene therapy.

[95]  Bassem A. Hassan,et al.  Math1: an essential gene for the generation of inner ear hair cells. , 1999, Science.

[96]  P. G. Walsh,et al.  The epidemiology of hearing impairment in an Australian adult population. , 1999, International journal of epidemiology.

[97]  P. Decouflé,et al.  Prevalence and characteristics of children with serious hearing impairment in metropolitan Atlanta, 1991-1993. , 1999, Pediatrics.

[98]  Bernd Fritzsch,et al.  Making and breaking the innervation of the ear: neurotrophic support during ear development and its clinical implications , 1999, Cell and Tissue Research.

[99]  Thomas Friedrich,et al.  KCNQ4, a Novel Potassium Channel Expressed in Sensory Outer Hair Cells, Is Mutated in Dominant Deafness , 1999, Cell.

[100]  J. Schacht,et al.  Stimulation of free radical formation by aminoglycoside antibiotics 1 The data in this paper have been presented, in part, at the meeting of the Association for Research in Otolaryngology, February 1996. 1 , 1999, Hearing Research.

[101]  K. Xia,et al.  Mutations in the gene encoding gap junction protein β-3 associated with autosomal dominant hearing impairment , 1998, Nature Genetics.

[102]  M. Barbacid,et al.  The combined effects of trkB and trkC mutations on the innervation of the inner ear , 1998, International Journal of Developmental Neuroscience.

[103]  A. Salt,et al.  Longitudinal endolymph movements induced by perilymphatic injections , 1998, Hearing Research.

[104]  H. Staecker,et al.  Factors controlling hair-cell regeneration/repair in the inner ear , 1998, Current Opinion in Neurobiology.

[105]  C. Morton,et al.  Association of unconventional myosin MYO15 mutations with human nonsyndromic deafness DFNB3. , 1998, Science.

[106]  B. Chait,et al.  The structure of the potassium channel: molecular basis of K+ conduction and selectivity. , 1998, Science.

[107]  M. King,et al.  Mutation in transcription factor POU4F3 associated with inherited progressive hearing loss in humans. , 1998, Science.

[108]  A. Fire,et al.  Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans , 1998, Nature.

[109]  A. Kakigi,et al.  Effect of artificial endolymph injection into the cochlear duct on the endocochlear potential , 1998, Hearing Research.

[110]  David W. Lin,et al.  Breakdown of Stria Vascularis Blood-Labyrinth Barrier in C3H/lpr Autoimmune Disease Mice , 1997, Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery.

[111]  D. Trune.  Cochlear Immunoglobulin in the C3H/lpr Mouse Model for Autoimmune Hearing Loss , 1997, Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery.

[112]  Paul Kruszka,et al.  Neurotrophins can enhance spiral ganglion cell survival after inner hair cell loss , 1997, International Journal of Developmental Neuroscience.

[113]  D. Kelsell,et al.  Connexin 26 mutations in hereditary non-syndromic sensorineural deafness , 1997, nature.

[114]  A. Kay,et al.  Trophic Support of Cultured Spiral Ganglion Neurons by Depolarization Exceeds and Is Additive with that by Neurotrophins or cAMP and Requires Elevation of [Ca2+]i within a Set Range , 1997, The Journal of Neuroscience.

[115]  T. Deacon,et al.  Specific axon guidance factors persist in the adult brain as demonstrated by pig neuroblasts transplanted to the rat , 1996, Neuroscience.

[116]  F. Gage,et al.  Differentiation of adult hippocampus-derived progenitors into olfactory neurons in vivo , 1996, Nature.

[117]  J. T. Corwin,et al.  Regenerative Proliferation in Organ Cultures of the Avian Cochlea: Identification of the Initial Progenitors and Determination of the Latency of the Proliferative Response , 1996, The Journal of Neuroscience.

[118]  B Malgrange,et al.  NT‐3 and/or BDNF therapy prevents loss of auditory neurons following loss of hair cells , 1996, Neuroreport.

[119]  F. Gage,et al.  Survival and differentiation of adult neuronal progenitor cells transplanted to the adult brain. , 1995, Proceedings of the National Academy of Sciences of the United States of America.

[120]  Rudolf Jaenisch,et al.  Complementary roles of BDNF and NT-3 in vestibular and auditory development , 1995, Neuron.

[121]  M. Brandon,et al.  Membrane dynamics during migration of placental cells through trophectodermal tight junctions in sheep and goats , 1994, Cell and Tissue Research.

[122]  T. Tamiya,et al.  Gene transfer into experimental brain tumors mediated by adenovirus, herpes simplex virus, and retrovirus vectors. , 1994, Human gene therapy.

[123]  J. T. Corwin,et al.  Ultrastructural evidence for hair cell regeneration in the mammalian inner ear. , 1993, Science.

[124]  J. T. Corwin,et al.  Regenerative proliferation in inner ear sensory epithelia from adult guinea pigs and humans. , 1993, Science.

[125]  T. Takeda,et al.  Pressure Relationship between Perilymph and Endolymph Associated with Endolymphatic Infusion , 1991, The Annals of otology, rhinology, and laryngology.

[126]  S. Cannon,et al.  Evaluation of Eighth Nerve Integrity by the Electrically Evoked Middle Latency Response , 1989, Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery.

[127]  F. Wooding,et al.  Cell migration in the ruminant placenta: a freeze-fracture study. , 1983, Journal of ultrastructure research.

[128]  F. Linthicum,et al.  Viable spiral ganglion cells in congenital and acquired profound hearing loss , 1980, The Journal of Laryngology & Otology.

[129]  B. Clopton,et al.  Estimates of Essential Neural Elements for Stimulation through a Cochlear Prosthesis , 1980, The Annals of otology, rhinology & laryngology. Supplement.

[130]  H. Schuknecht,et al.  Ganglion cell populations in normal and pathological human cochleae. Implications for cochlear implantation. , 1978, The Laryngoscope.

[131]  M. Stroud,et al.  Clinical differentiation of conductive hearing loss , 1978, The Laryngoscope.

[132]  J. Frisén,et al.  Survival and neural differentiation of adult neural stem cells transplanted into the mature inner ear. , 2005, Experimental cell research.

[133]  J. Ito,et al.  Survival of neural stem cells in the cochlea. , 2001, Acta oto-laryngologica.

[134]  Y. Raphael,et al.  Transduction of the contralateral ear after adenovirus-mediated cochlear gene transfer , 2000, Gene Therapy.

[135]  E. Mäki-Torkko,et al.  Epidemiology of moderate to profound childhood hearing impairments in northern Finland. Any changes in ten years? , 1998, Scandinavian audiology.

[136]  T. Marttila,et al.  Prevalence of childhood hearing impairment in southern Finland. , 1995, Scandinavian audiology.

[137]  F. Gage,et al.  Isolation, characterization, and use of stem cells from the CNS. , 1995, Annual review of neuroscience.

[138]  A. Davis.  Epidemiological profile of hearing impairments: the scale and nature of the problem with special reference to the elderly. , 1990, Acta oto-laryngologica. Supplementum.

[139]  S. Juhn,et al.  Barrier systems in the inner ear. , 1988, Acta oto-laryngologica. Supplementum.

[140]  J. Pickles.  An Introduction to the Physiology of Hearing , 1982 .

[141]  H. Spoendlin.  Neuroanatomical basis of cochlear coding mechanisms. , 1975, Audiology : official organ of the International Society of Audiology.

[142]  H. Schuknecht,et al.  The Spiral Ganglion In Profound Deafness , 1968 .