Major histocompatibility complex-directed susceptibility to rheumatoid arthritis.

[1]  T. Lybrand,et al.  Use of T cell receptor/HLA-DRB1*04 molecular modeling to predict site-specific interactions for the DR shared epitope associated with rheumatoid arthritis. , 1997, Arthritis and rheumatism.

[2]  G. Nepom,et al.  MHC-DRB allelic sequences incorporate distinct intragenic trans-specific segments. , 1997, Tissue antigens.

[3]  P. Davis,et al.  Immunogenetic similarities between patients with Felty's syndrome and those with clonal expansions of large granular lymphocytes in rheumatoid arthritis. , 1997, Arthritis and rheumatism.

[4]  E. Zanelli,et al.  Critical residues on HLA-DRB1*0402 HV3 peptide for HLA-DQ8-restricted immunogenicity: implications for rheumatoid arthritis predisposition. , 1997, Journal of immunology.

[5]  U. Wagner,et al.  HLA markers and prediction of clinical course and outcome in rheumatoid arthritis. , 1997, Arthritis and rheumatism.

[6]  L. Mitchell,et al.  HLA-DR restrictive supertypes dominate promiscuous T cell recognition: association of multiple HLA-DR molecules with susceptibility to autoimmune diseases. , 1997, The Journal of rheumatology.

[7]  H. Rammensee,et al.  A distinctive peptide binding motif for HLA-DRB1*0407, an HLA-DR4 subtype not associated with rheumatoid arthritis , 1997, Immunogenetics.

[8]  S. Pillemer,et al.  HLA-DRB1 genes and disease severity in rheumatoid arthritis. The MIRA Trial Group. Minocycline in Rheumatoid Arthritis. , 1996, Arthritis and rheumatism.

[9]  G. Nepom,et al.  Critical contribution of beta chain residue 57 in peptide binding ability of both HLA-DR and -DQ molecules. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[10]  G. Nepom,et al.  Ancestral major histocompatibility complex DRB genes beget conserved patterns of localized polymorphisms. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[11]  J. O'dell,et al.  Treatment of rheumatoid arthritis with methotrexate alone, sulfasalazine and hydroxychloroquine, or a combination of all three medications. , 1996, The New England journal of medicine.

[12]  T. Lybrand,et al.  Recognition of altered self major histocompatibility complex molecules modulated by specific peptide interactions , 1996, European journal of immunology.

[13]  T. Lybrand,et al.  A structural model for TCR recognition of the HLA class II shared epitope sequence implicated in susceptibility to rheumatoid arthritis. , 1996, Journal of autoimmunity.

[14]  V. Gnau,et al.  Natural ligand motifs of closely related HLA-DR4 molecules predict features of rheumatoid arthritis associated peptides. , 1996, Biochimica et biophysica acta.

[15]  E. Zanelli,et al.  Immune response of HLA-DQ8 transgenic mice to peptides from the third hypervariable region of HLA-DRB1 correlates with predisposition to rheumatoid arthritis. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[16]  V. Gersuk,et al.  Prognostic implications of HLA genotyping in the early assessment of patients with rheumatoid arthritis. , 1996, The Journal of rheumatology. Supplement.

[17]  I. Auger,et al.  HLA–DR4 and HLA–DR10 motifs that carry susceptibility to rheumatoid arthritis bind 70–kD heat shock proteins , 1996, Nature Medicine.

[18]  G. Nepom,et al.  HLA-DQB1 codon 57 is critical for peptide binding and recognition , 1996, The Journal of experimental medicine.

[19]  P. Lipsky,et al.  Presentation of self peptides by dendritic cells: possible implications for the pathogenesis of rheumatoid arthritis. , 1996, Arthritis and rheumatism.

[20]  J. Reginster,et al.  Rheumatic and musculoskeletal diseases and impaired quality of life: a challenge for rheumatologists. , 1996, The Journal of rheumatology.

[21]  J. Yélamos,et al.  Association of the shared epitope with radiological severity of rheumatoid arthritis. , 1996, The Journal of rheumatology.

[22]  D. Kirschmann,et al.  Naturally processed peptides from rheumatoid arthritis associated and non-associated HLA-DR alleles. , 1995, Journal of immunology.

[23]  R. Karr,et al.  Negatively charged residues interacting with the p4 pocket confer binding specificity to DRB1*0401. , 1995, Arthritis and rheumatism.

[24]  Partho Ghosh,et al.  The structure of an intermediate in class II MHC maturation: CLIP bound to HLA-DR3 , 1995, Nature.

[25]  R. Karr,et al.  Structural requirements of peptide and MHC for DR(alpha, beta 1*0401)-restricted T cell antigen recognition. , 1995, Journal of immunology.

[26]  J. Reveille,et al.  Most African-American Patients with Rheumatoid Arthritis Do Not Have the Rheumatoid Antigenic Determinant (Epitope) , 1995, Annals of Internal Medicine.

[27]  P. Tugwell,et al.  Combination therapy with cyclosporine and methotrexate in severe rheumatoid arthritis. The Methotrexate-Cyclosporine Combination Study Group. , 1995, The New England journal of medicine.

[28]  F. Breedveld New perspectives on treating rheumatoid arthritis. , 1995, The New England journal of medicine.

[29]  A. Hill,et al.  Naturally processed peptides from two disease-resistance-associated HLA-DR13 alleles show related sequence motifs and the effects of the dimorphism at position 86 of the HLA-DR beta chain. , 1995, Proceedings of the National Academy of Sciences of the United States of America.

[30]  M. González-Gay,et al.  Could HLA-DRB1 be the protective locus in rheumatoid arthritis? , 1995, Immunology today.

[31]  J. Daurès,et al.  Prognostic factors in rheumatoid arthritis. Comparative study of two subsets of patients according to severity of articular damage. , 1995, British journal of rheumatology.

[32]  C. Weyand,et al.  Correlation between disease phenotype and genetic heterogeneity in rheumatoid arthritis. , 1995, The Journal of clinical investigation.

[33]  R. Karr,et al.  Peptide binding specificity of HLA-DR4 molecules: correlation with rheumatoid arthritis association , 1995, The Journal of experimental medicine.

[34]  A. Sette,et al.  Pocket 4 of the HLA-DR(alpha,beta 1*0401) molecule is a major determinant of T cells recognition of peptide , 1995, The Journal of experimental medicine.

[35]  A. Sette,et al.  Tolerance to a self-peptide from the third hypervariable region of HLA DRB1*0401 in rheumatoid arthritis patients and normal subjects. , 1994, Journal of immunology.

[36]  Paul Wordsworth,et al.  Genetic typing of patients with inflammatory arthritis at presentation can be used to predict outcome. , 1994, Arthritis and rheumatism.

[37]  Z. Nagy,et al.  Precise prediction of major histocompatibility complex class II-peptide interaction based on peptide side chain scanning , 1994, The Journal of experimental medicine.

[38]  S. Matsushita,et al.  Allele specificity of structural requirement for peptides bound to HLA- DRB1*0405 and -DRB1*0406 complexes: implication for the HLA-associated susceptibility to methimazole-induced insulin autoimmune syndrome , 1994, The Journal of experimental medicine.

[39]  D. Zaller,et al.  Prediction of peptide affinity to HLA DRB1*0401. , 1994, International archives of allergy and immunology.

[40]  Don C. Wiley,et al.  Crystal structure of the human class II MHC protein HLA-DR1 complexed with an influenza virus peptide , 1994, Nature.

[41]  J. Trowsdale,et al.  Novel genes in the human major histocompatibility complex class-II region. , 1994, International archives of allergy and immunology.

[42]  A. Begovich,et al.  Erosive rheumatoid factor negative and positive rheumatoid arthritis are immunogenetically similar. , 1994, The Journal of rheumatology.

[43]  M F del Guercio,et al.  HLA DR4w4-binding motifs illustrate the biochemical basis of degeneracy and specificity in peptide-DR interactions. , 1993, Journal of immunology.

[44]  William Arbuthnot Sir Lane,et al.  Specificity and promiscuity among naturally processed peptides bound to HLA-DR alleles , 1993, The Journal of experimental medicine.

[45]  G. Nepom,et al.  Autoreactive T cells from a type I diabetic recognize multiple class II products. , 1993, Human immunology.

[46]  Antonio Lanzavecchia,et al.  The set of naturally processed peptides displayed by DR molecules is tuned by polymorphism of residue 86 , 1993, European journal of immunology.

[47]  C. Weyand,et al.  The Influence of HLA-DRB1 Genes on Disease Severity in Rheumatoid Arthritis , 1992, Annals of Internal Medicine.

[48]  N. Gt,et al.  Prediction of susceptibility to rheumatoid arthritis by human leukocyte antigen genotyping. , 1992 .

[49]  W. Thomson,et al.  Population genetics of rheumatoid arthritis. , 1992, Rheumatic diseases clinics of North America.

[50]  Paul Wordsworth,et al.  HLA heterozygosity contributes to susceptibility to rheumatoid arthritis. , 1992, American journal of human genetics.

[51]  H. Mcdevitt,et al.  Evolution of major histocompatibility complex class II allelic diversity: direct descent in mice and humans. , 1992, Proceedings of the National Academy of Sciences of the United States of America.

[52]  R. Vaughan,et al.  HLA class II sequence polymorphisms and susceptibility to rheumatoid arthritis in Greeks. The HLA-DR beta shared-epitope hypothesis accounts for the disease in only a minority of Greek patients. , 1992, Arthritis and rheumatism.

[53]  L. Andersson,et al.  Exon encoding the antigen-binding site of MHC class II beta-chains is divided into two subregions with different evolutionary histories. , 1992, Journal of immunology.

[54]  S. Albani,et al.  The susceptibility sequence to rheumatoid arthritis is a cross-reactive B cell epitope shared by the Escherichia coli heat shock protein dnaJ and the histocompatibility leukocyte antigen DRB10401 molecule. , 1992, The Journal of clinical investigation.

[55]  P. Kraulis A program to produce both detailed and schematic plots of protein structures , 1991 .

[56]  A. Zwinderman,et al.  Association of HLA-DR4 with a more progressive disease course in patients with rheumatoid arthritis. Results of a followup study. , 1991, Arthritis and rheumatism.

[57]  J. Ragoussis,et al.  Cloning of the HLA class II region in yeast artificial chromosomes. , 1991, Proceedings of the National Academy of Sciences of the United States of America.

[58]  H. Erlich,et al.  Allelic diversity is generated by intraexon sequence exchange at the DRB1 locus of primates. , 1991, Proceedings of the National Academy of Sciences of the United States of America.

[59]  G. Nepom,et al.  Association of HLA-Dw16 with rheumatoid arthritis in Yakima Indians. Further evidence for the "shared epitope" hypothesis. , 1991, Arthritis and rheumatism.

[60]  E. Thorsby,et al.  Rheumatoid arthritis may be primarily associated with HLA-DR4 molecules sharing a particular sequence at residues 67-74. , 1990, Tissue antigens.

[61]  J. Hansen,et al.  Structural requirements for recognition of the HLA-Dw14 class II epitope: a key HLA determinant associated with rheumatoid arthritis. , 1990, Proceedings of the National Academy of Sciences of the United States of America.

[62]  T. Pincus,et al.  HLA-DR alleles with naturally occurring amino acid substitutions and risk for development of rheumatoid arthritis. , 1990, Arthritis and rheumatism.

[63]  J. Bell,et al.  HLA-DR4 subtype frequencies in rheumatoid arthritis indicate that DRB1 is the major susceptibility locus within the HLA class II region. , 1989, Proceedings of the National Academy of Sciences of the United States of America.

[64]  A. Calin,et al.  Destructive arthritis, rheumatoid factor, and HLA-DR4. Susceptibility versus severity, a case-control study. , 1989, Arthritis and rheumatism.

[65]  J. Roudier,et al.  Susceptibility to rheumatoid arthritis maps to a T-cell epitope shared by the HLA-Dw4 DR beta-1 chain and the Epstein-Barr virus glycoprotein gp110. , 1989, Proceedings of the National Academy of Sciences of the United States of America.

[66]  D. Stage,et al.  HLA genes associated with rheumatoid arthritis. Identification of susceptibility alleles using specific oligonucleotide probes. , 1989, Arthritis and rheumatism.

[67]  T. Pincus,et al.  Associations of HLA-DR4 with rheumatoid factor and radiographic severity in rheumatoid arthritis. , 1988, The American journal of medicine.

[68]  P. Gregersen,et al.  The shared epitope hypothesis. An approach to understanding the molecular genetics of susceptibility to rheumatoid arthritis. , 1987, Arthritis and rheumatism.

[69]  William N. Kelley,et al.  Textbook of rheumatology , 1985 .