New quinazoline sulfonamide derivatives as potential anticancer agents: Identifying a promising hit with dual EGFR/VEGFR-2 inhibitory and radiosensitizing activity.
暂无分享,去创建一个
[1] M. El-Zahabi,et al. Novel promising benzoxazole/benzothiazole‐derived immunomodulatory agents: Design, synthesis, anticancer evaluation, and in silico ADMET analysis , 2023, Archiv der Pharmazie.
[2] M. Ghoneim,et al. Design, synthesis, and docking of novel thiazolidine‐2,4‐dione multitarget scaffold as new approach for cancer treatment , 2023, Archiv der Pharmazie.
[3] M. El-Zahabi,et al. Design, synthesis, anticancer evaluation, in silico docking and ADMET analysis of novel indole-based thalidomide analogs as promising immunomodulatory agents. , 2023, Journal of biomolecular structure & dynamics.
[4] I. Eissa,et al. Immunomodulatory quinazoline-based thalidomide analogs: Design, synthesis, apoptosis and anticancer evaluations , 2023, Journal of Molecular Structure.
[5] Riham F. George,et al. Exploration of thiazolidine‐2,4‐diones as tyrosine kinase inhibitors: Design, synthesis, ADMET, docking, and antiproliferative evaluations , 2022, Archiv der Pharmazie.
[6] F. Ragab,et al. Antiproliferative, antiangiogenic and apoptotic effect of new hybrids of quinazoline-4(3H)-ones and sulfachloropyridazine. , 2022, European journal of medicinal chemistry.
[7] Xi Chen,et al. Design, Synthesis and Antitumor Activities of Novel Quinazolinone Derivatives as Potential EGFR Inhibitors. , 2022, Chemical & pharmaceutical bulletin.
[8] Riham F. George,et al. Design and synthesis of some new 6-bromo-2-(pyridin-3-yl)-4-substituted quinazolines as multi tyrosine kinase inhibitors. , 2022, Bioorganic chemistry.
[9] Reihane Ghomashi,et al. Recent Advances on Biological Active Sulfonamide based Hybrid Compounds Part A: Two-Component Sulfonamide Hybrids. , 2022, Current medicinal chemistry.
[10] Riham F. George,et al. Design, synthesis, in silico docking, ADMET and anticancer evaluations of thiazolidine-2,4-diones bearing heterocyclic rings as dual VEGFR-2/EGFRT790M tyrosine kinase inhibitors , 2022, RSC advances.
[11] M. Abdelgawad,et al. Design, Molecular Docking, Synthesis, Anticancer and Anti-Hyperglycemic Assessments of Thiazolidine-2,4-diones Bearing Sulfonylthiourea Moieties as Potent VEGFR-2 Inhibitors and PPARγ Agonists , 2022, Pharmaceuticals.
[12] Shengmin Shi,et al. Dual target inhibitors based on EGFR: Promising anticancer agents for the treatment of cancers (2017-). , 2021, European journal of medicinal chemistry.
[13] I. Eissa,et al. Phthalazine‐based VEGFR‐2 inhibitors: Rationale, design, synthesis, in silico, ADMET profile, docking, and anticancer evaluations , 2021, Archiv der Pharmazie.
[14] S. Salama,et al. Design, synthesis, molecular docking and in silico ADMET profile of pyrano[2,3-d]pyrimidine derivatives as antimicrobial and anticancer agents. , 2021, Bioorganic chemistry.
[15] C. Supuran,et al. Biological evaluation, radiosensitizing activity and structural insights of novel halogenated quinazoline-sulfonamide conjugates as selective human carbonic anhydrases IX/XII inhibitors. , 2021, Bioorganic chemistry.
[16] M. Abdel-Kader,et al. Synthesis of some quinazolinones inspired from the natural alkaloid L-norephedrine as EGFR inhibitors and radiosensitizers , 2020, Journal of enzyme inhibition and medicinal chemistry.
[17] M. Kamal,et al. Tumor angiogenesis and VEGFR-2: mechanism, pathways and current biological therapeutic interventions. , 2020, Current drug metabolism.
[18] K. Wagner,et al. PPARs and Angiogenesis—Implications in Pathology , 2020, International journal of molecular sciences.
[19] K. Abouzid,et al. Scaffold hopping and redesign approaches for quinazoline based urea derivatives as potent VEGFR-2 inhibitors. , 2020, Bioorganic chemistry.
[20] C. Supuran,et al. Iodoquinazolinones bearing benzenesulfonamide as human carbonic anhydrase I, II, IX and XII inhibitors: Synthesis, biological evaluation and radiosensitizing activity. , 2020, European journal of medicinal chemistry.
[21] A. Foroumadi,et al. A review on progression of epidermal growth factor receptor (EGFR) inhibitors as an efficient approach in cancer targeted therapy. , 2020, Bioorganic chemistry.
[22] Ahmed M. El Kerdawy,et al. Design and Synthesis of some new 2,4,6-trisubstituted quinazoline EGFR inhibitors as targeted anticancer agents. , 2020, Bioorganic chemistry.
[23] I. Eissa,et al. Design, synthesis, molecular docking, and anticancer activity of benzoxazole derivatives as VEGFR‐2 inhibitors , 2019, Archiv der Pharmazie.
[24] A. Alqahtani,et al. Novel sulphonamide benzoquinazolinones as dual EGFR/HER2 inhibitors, apoptosis inducers and radiosensitizers , 2019, Journal of enzyme inhibition and medicinal chemistry.
[25] M. Alsaid,et al. Dual EGFR/HER2 inhibitors and apoptosis inducers: New benzo[g]quinazoline derivatives bearing benzenesulfonamide as anticancer and radiosensitizers. , 2018, Bioorganic chemistry.
[26] A. Karsan,et al. Evidence-based best practices for EGFR T790M testing in lung cancer in Canada. , 2018, Current oncology.
[27] Kongming Wu,et al. EGFR-TKIs resistance via EGFR-independent signaling pathways , 2018, Molecular Cancer.
[28] Mamdouh M. Ali,et al. Design, Synthesis, Molecular Docking, and Anticancer Activity of Phthalazine Derivatives as VEGFR‐2 Inhibitors , 2017, Archiv der Pharmazie.
[29] F. Ragab,et al. Discovery of Benzo[g]quinazolin benzenesulfonamide derivatives as dual EGFR/HER2 inhibitors. , 2017, European journal of medicinal chemistry.
[30] M. Alsaid,et al. Benzo[g]quinazolin-based scaffold derivatives as dual EGFR/HER2 inhibitors , 2017, Journal of enzyme inhibition and medicinal chemistry.
[31] D. Frezzetti,et al. VEGF as a potential target in lung cancer , 2017, Expert opinion on therapeutic targets.
[32] Mamdouh M. Ali,et al. Design, synthesis, molecular docking and cytotoxic evaluation of novel 2-furybenzimidazoles as VEGFR-2 inhibitors. , 2017, European journal of medicinal chemistry.
[33] Xueyan Yu,et al. EGFR TKI as first-line treatment for patients with advanced EGFR mutation-positive non-small-cell lung cancer , 2017, Oncotarget.
[34] F. Ragab,et al. Aromatase inhibitors and apoptotic inducers: Design, synthesis, anticancer activity and molecular modeling studies of novel phenothiazine derivatives carrying sulfonamide moiety as hybrid molecules. , 2017, European journal of medicinal chemistry.
[35] Li‐Ping Sun,et al. Design and discovery of 4-anilinoquinazoline-urea derivatives as dual TK inhibitors of EGFR and VEGFR-2. , 2017, European journal of medicinal chemistry.
[36] F. Ragab,et al. VEGFR-2 inhibitors and apoptosis inducers: synthesis and molecular design of new benzo[g]quinazolin bearing benzenesulfonamide moiety , 2017, Journal of enzyme inhibition and medicinal chemistry.
[37] P. Kulkarni,et al. 5-Benzylidene-2,4-thiazolidenedione derivatives: Design, synthesis and evaluation as inhibitors of angiogenesis targeting VEGR-2. , 2016, Bioorganic chemistry.
[38] Philip J. Chapman,et al. The discovery of 2-substituted phenol quinazolines as potent RET kinase inhibitors with improved KDR selectivity , 2016, European journal of medicinal chemistry.
[39] Rui M. V. Abreu,et al. Synthesis, antiangiogenesis evaluation and molecular docking studies of 1-aryl-3-[(thieno[3,2-b]pyridin-7-ylthio)phenyl]ureas: Discovery of a new substitution pattern for type II VEGFR-2 Tyr kinase inhibitors. , 2015, Bioorganic & medicinal chemistry.
[40] V. Torri,et al. Is there evidence for different effects among EGFR-TKIs? Systematic review and meta-analysis of EGFR tyrosine kinase inhibitors (TKIs) versus chemotherapy as first-line treatment for patients harboring EGFR mutations. , 2015, Critical reviews in oncology/hematology.
[41] R. Wahl,et al. Chemotherapy and Chemoprevention by Thiazolidinediones , 2015, BioMed research international.
[42] C. Ramaa,et al. A new dawn for the use of thiazolidinediones in cancer therapy , 2014, Expert opinion on investigational drugs.
[43] Huan-qiu Li,et al. Epidermal growth factor receptor inhibitors: a patent review (2010 – present) , 2014, Expert opinion on therapeutic patents.
[44] F. Totzke,et al. Novel 2-chloro-4-anilino-quinazoline derivatives as EGFR and VEGFR-2 dual inhibitors. , 2014, European journal of medicinal chemistry.
[45] W. Pao,et al. Targeted therapies: Afatinib—new therapy option for EGFR-mutant lung cancer , 2013, Nature Reviews Clinical Oncology.
[46] P. Johnston,et al. Cancer drug resistance: an evolving paradigm , 2013, Nature Reviews Cancer.
[47] A. Dahan,et al. Oral Delivery of Lipophilic Drugs: The Tradeoff between Solubility Increase and Permeability Decrease When Using Cyclodextrin-Based Formulations , 2013, PloS one.
[48] Yoshikazu Ohta,et al. Structure-Based Approach for the Discovery of Pyrrolo[3,2-d]pyrimidine-Based EGFR T790M/L858R Mutant Inhibitors. , 2013, ACS medicinal chemistry letters.
[49] D. Ingber,et al. Forty-Year Journey of Angiogenesis Translational Research , 2011, Science Translational Medicine.
[50] Xiaoyuan Chen,et al. Integrin Targeted Delivery of Radiotherapeutics , 2011, Theranostics.
[51] Kyungik Lee,et al. Pharmacophore modeling and virtual screening studies for new VEGFR-2 kinase inhibitors. , 2010, European journal of medicinal chemistry.
[52] Paul Dent,et al. Synergistic combinations of signaling pathway inhibitors: mechanisms for improved cancer therapy. , 2009, Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy.
[53] L. Byers,et al. Dual targeting of the vascular endothelial growth factor and epidermal growth factor receptor pathways: rationale and clinical applications for non-small-cell lung cancer. , 2007, Clinical lung cancer.
[54] S. Wilhelm,et al. Discovery and development of sorafenib: a multikinase inhibitor for treating cancer , 2006, Nature Reviews Drug Discovery.
[55] N. Gray,et al. Rational design of inhibitors that bind to inactive kinase conformations , 2006, Nature chemical biology.
[56] D. Shima,et al. VEGF function in vascular pathogenesis. , 2006, Experimental cell research.
[57] E. Scholar,et al. Role of Tyrosine Kinase Inhibitors in Cancer Therapy , 2005, Journal of Pharmacology and Experimental Therapeutics.
[58] D. Schuppan,et al. Erlotinib induces cell cycle arrest and apoptosis in hepatocellular cancer cells and enhances chemosensitivity towards cytostatics. , 2005, Journal of hepatology.
[59] Sui Huang,et al. PPARγ as a therapeutic target for tumor angiogenesis and metastasis , 2005 .
[60] V. Boddi,et al. Correlation of Epidermal Growth Factor Receptor Expression with Tumor Microdensity Vessels and with Vascular Endothelial Growth Factor Expression in Ovarian Carcinoma , 2005, International journal of surgical pathology.
[61] A. Ullrich,et al. The discovery of receptor tyrosine kinases: targets for cancer therapy , 2004, Nature Reviews Cancer.
[62] Susan M. Kilroy,et al. PPARgamma ligands inhibit primary tumor growth and metastasis by inhibiting angiogenesis. , 2002, The Journal of clinical investigation.
[63] C. Arteaga. Epidermal growth factor receptor dependence in human tumors: more than just expression? , 2002, The oncologist.
[64] P. Furet,et al. Strategies toward the design of novel and selective protein tyrosine kinase inhibitors. , 1999, Pharmacology & therapeutics.
[65] W. Clark,et al. Biomarkers for individual susceptibility to carcinogenic agents: excretion and carcinogenic risk of benzo[a]pyrene metabolites. , 1992, Environmental health perspectives.
[66] D. Scudiero,et al. Evaluation of a soluble tetrazolium/formazan assay for cell growth and drug sensitivity in culture using human and other tumor cell lines. , 1988, Cancer research.
[67] Khaled El-Adl,et al. Pyrazolo[3,4-d]pyrimidine derivatives as EGFRT790M and VEGFR-2 dual TK inhibitors: Design, synthesis, molecular docking, ADMET profile and anticancer evaluations , 2023, Journal of Molecular Structure.
[68] R. Salgia,et al. Gefitinib response of erlotinib-refractory lung cancer involving meninges—role of EGFR mutation , 2006, Nature Clinical Practice Oncology.
[69] L. Ellis,et al. Vascular endothelial growth factor receptors: expression and function in solid tumors. , 2004, Clinical advances in hematology & oncology : H&O.
[70] F. Lombardo,et al. Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings. , 2001, Advanced drug delivery reviews.
[71] M. Shibuya,et al. Structure and function of vascular endothelial growth factor receptor-1 and -2. , 1999, Current topics in microbiology and immunology.
[72] J C Bailar,et al. Cancer undefeated. , 1997, The New England journal of medicine.