Alzheimer’s Disease and Speech Background

Developing a possible diagnostic test for Alzheimer’s disease (AD) based on speech is used throughout this book to illustrate the application of the machine learning methods we describe. This application has many of the characteristics typical of such tasks: one has some idea that a set of features characterizing samples that one possesses might be able to classify the objects into two or more classes. Lacking sufficient depth of understanding of how this might be caused, one goes searching for useful patterns in the data—a fishing expedition.

[1]  William Dale,et al.  Olfactory Dysfunction Predicts Subsequent Dementia in Older U.S. Adults , 2018, Journal of the American Geriatrics Society.

[2]  Beatrice Santorini,et al.  Building a Large Annotated Corpus of English: The Penn Treebank , 1993, CL.

[3]  Victor H. Yngve,et al.  A model and an hypothesis for language structure , 1960 .

[4]  Brian Roark,et al.  Spoken Language Derived Measures for Detecting Mild Cognitive Impairment , 2011, IEEE Transactions on Audio, Speech, and Language Processing.

[5]  Kirill Sakhnov,et al.  Dynamical Energy-Based Speech/Silence Detector for Speech Enhancement Applications , 2009 .

[6]  Sylvester Olubolu Orimaye,et al.  Learning Predictive Linguistic Features for Alzheimer’s Disease and related Dementias using Verbal Utterances , 2014, CLPsych@ACL.

[7]  A. Kertesz The Western Aphasia Battery , 1982 .

[8]  H. Sichel On a Distribution Law for Word Frequencies , 1975 .

[9]  D R Wekstein,et al.  Linguistic ability in early life and cognitive function and Alzheimer's disease in late life. Findings from the Nun Study. , 1996, JAMA.

[10]  Kathleen C. Fraser,et al.  Linguistic Features Identify Alzheimer's Disease in Narrative Speech. , 2015, Journal of Alzheimer's disease : JAD.

[11]  Herman Buschke,et al.  Abnormality of gait as a predictor of non-Alzheimer's dementia. , 2002, The New England journal of medicine.

[12]  R. Gunning The Technique of Clear Writing. , 1968 .

[13]  M. Coleman,et al.  A computer readability formula designed for machine scoring. , 1975 .

[14]  Hongbing Hu,et al.  A spectral/temporal method for robust fundamental frequency tracking. , 2008, The Journal of the Acoustical Society of America.

[15]  David A Bennett,et al.  Education and cognitive reserve in old age , 2019, Neurology.

[16]  Tanja Schultz,et al.  Manual and Automatic Transcriptions in Dementia Detection from Speech , 2017, INTERSPEECH.

[17]  J. Weuve,et al.  Alzheimer disease in the United States (2010–2050) estimated using the 2010 census , 2013, Neurology.

[18]  Jinglong Wu,et al.  Human Characteristics of Sound Localization under Masking for the Early Detection of Dementia , 2011 .

[19]  N. Cercone,et al.  Automatic detection and rating of dementia of Alzheimer type through lexical analysis of spontaneous speech , 2005, IEEE International Conference Mechatronics and Automation, 2005.

[20]  J. David Schaffer,et al.  Speech Processing Approach for Diagnosing Dementia in an Early Stage , 2017, INTERSPEECH.

[21]  Hyungsin Kim,et al.  The ClockMe system: computer-assisted screening tool for dementia , 2013 .

[22]  Eugene Charniak,et al.  A Maximum-Entropy-Inspired Parser , 2000, ANLP.

[23]  Philip Scheltens,et al.  Timely Diagnosis for Alzheimer’s Disease: A Literature Review on Benefits and Challenges , 2015, Journal of Alzheimer's disease : JAD.

[24]  Ryan L. Boyd,et al.  The Development and Psychometric Properties of LIWC2015 , 2015 .

[25]  Heidi Christensen,et al.  Diagnosing People with Dementia Using Automatic Conversation Analysis , 2016, INTERSPEECH.

[26]  K. Davis,et al.  A new rating scale for Alzheimer's disease. , 1984, The American journal of psychiatry.

[27]  K. Forbes-McKay,et al.  Detecting subtle spontaneous language decline in early Alzheimer’s disease with a picture description task , 2005, Neurological Sciences.

[28]  E. H. Simpson Measurement of Diversity , 1949, Nature.

[29]  S. Fay,et al.  Goal setting and attainment in Alzheimer’s disease patients treated with donepezil , 2002, Journal of neurology, neurosurgery, and psychiatry.

[30]  Peter Garrard,et al.  Features and machine learning classification of connected speech samples from patients with autopsy proven Alzheimer's disease with and without additional vascular pathology. , 2014, Journal of Alzheimer's disease : JAD.

[31]  P. Vemuri,et al.  Clinical epidemiology of Alzheimer’s disease: assessing sex and gender differences , 2014, Clinical epidemiology.

[32]  Wonyong Sung,et al.  A statistical model-based voice activity detection , 1999, IEEE Signal Processing Letters.

[33]  David Snowdon,et al.  Aging with Grace: What the Nun Study Teaches Us About Leading Longer, Healthier, and More Meaningful Lives , 2001 .

[34]  Michael A Covington,et al.  Automatic measurement of propositional idea density from part-of-speech tagging , 2008, Behavior research methods.

[35]  J. Schneider,et al.  National Institute on Aging–Alzheimer's Association guidelines for the neuropathologic assessment of Alzheimer's disease , 2012, Alzheimer's & Dementia.

[36]  B. Bornstein,et al.  [THE SENILE BRAIN]. , 1963, Harefuah.

[37]  S. Folstein,et al.  "Mini-mental state". A practical method for grading the cognitive state of patients for the clinician. , 1975, Journal of psychiatric research.

[38]  R. Kinno,et al.  Can the ‘Head-Turning Sign’ Be a Clinical Marker of Alzheimer's Disease? , 2011, Dementia and Geriatric Cognitive Disorders Extra.

[39]  Sarah E. Wallace,et al.  Performing Cookie Theft Picture Content Analyses to Delineate Cognitive-Communication Impairments , 2008 .

[40]  V. Manera,et al.  Automatic speech analysis for the assessment of patients with predementia and Alzheimer's disease , 2015, Alzheimer's & dementia.

[41]  Jesús B. Alonso,et al.  Feature selection for spontaneous speech analysis to aid in Alzheimer's disease diagnosis: A fractal dimension approach , 2015, Comput. Speech Lang..

[42]  G. Udny Yule,et al.  The statistical study of literary vocabulary , 1944 .

[43]  R. Stelzmann,et al.  An english translation of alzheimer's 1907 paper, “über eine eigenartige erkankung der hirnrinde” , 1995, Clinical anatomy.

[44]  R. Flesch A new readability yardstick. , 1948, The Journal of applied psychology.

[45]  Ronald C Petersen,et al.  Comparison of Gait Parameters for Predicting Cognitive Decline: The Mayo Clinic Study of Aging. , 2016, Journal of Alzheimer's disease : JAD.

[46]  M. Weiner Commentary on “Diagnosis of Alzheimer's disease: Two decades of progress.” Central role of technology in the treatment and prevention of Alzheimer's disease , 2005, Alzheimer's & Dementia.

[47]  M. Gatz,et al.  Relationship Between Education and Dementia: An Updated Systematic Review , 2011, Alzheimer disease and associated disorders.

[48]  Sheldon Rosenberg,et al.  Indicators of linguistic competence in the peer group conversational behavior of mildly retarded adults , 1987, Applied Psycholinguistics.