Ginsenoside Rg1 protects against ischemic/reperfusion-induced neuronal injury through miR-144/Nrf2/ARE pathway

[1]  N. Chen,et al.  Upregulating the Expression of Survivin-HBXIP Complex Contributes to the Protective Role of IMM-H004 in Transient Global Cerebral Ischemia/Reperfusion , 2018, Molecular Neurobiology.

[2]  Luyong Zhang,et al.  A Dual AMPK/Nrf2 Activator Reduces Brain Inflammation After Stroke by Enhancing Microglia M2 Polarization. , 2018, Antioxidants & redox signaling.

[3]  Jun Wang,et al.  Protective effects of geniposide and ginsenoside Rg1 combination treatment on rats following cerebral ischemia are mediated via microglial microRNA‑155‑5p inhibition. , 2017, Molecular medicine reports.

[4]  M. Bennett,et al.  Oxidative stress and DNA damage after cerebral ischemia: Potential therapeutic targets to repair the genome and improve stroke recovery , 2017, Neuropharmacology.

[5]  Yaqi Tan,et al.  C19, a C-terminal peptide of CKLF1, decreases inflammation and proliferation of dermal capillaries in psoriasis , 2017, Scientific Reports.

[6]  Honglin Li,et al.  Britanin Ameliorates Cerebral Ischemia-Reperfusion Injury by Inducing the Nrf2 Protective Pathway. , 2017, Antioxidants & redox signaling.

[7]  N. Chen,et al.  IMM-H004, A New Coumarin Derivative, Improved Focal Cerebral Ischemia via Blood-Brain Barrier Protection in Rats. , 2017, Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association.

[8]  Mengxue Xu,et al.  Nrf2—a Promising Therapeutic Target for Defensing Against Oxidative Stress in Stroke , 2017, Molecular Neurobiology.

[9]  Liangyu Zhang,et al.  Nrf2/ARE pathway inhibits ROS-induced NLRP3 inflammasome activation in BV2 cells after cerebral ischemia reperfusion , 2017, Inflammation Research.

[10]  Ping Liu,et al.  MicroRNA-144 modulates oxidative stress tolerance in SH-SY5Y cells by regulating nuclear factor erythroid 2-related factor 2-glutathione axis , 2017, Neuroscience Letters.

[11]  Yan Zheng,et al.  Inhibition of microRNA‐153 protects neurons against ischemia/reperfusion injury in an oxygen–glucose deprivation and reoxygenation cellular model by regulating Nrf2/HO‐1 signaling , 2017, Journal of biochemical and molecular toxicology.

[12]  R. Morishita,et al.  Angiotensin II Peptide Vaccine Protects Ischemic Brain Through Reducing Oxidative Stress , 2017, Stroke.

[13]  Yang Liu,et al.  Protective effects of ginsenoside Rg1 against oxygen-glucose-deprivation-induced apoptosis in neural stem cells , 2017, Journal of the Neurological Sciences.

[14]  Shi-feng Chu,et al.  Antioxidant activities of ginsenoside Rg1 against cisplatin-induced hepatic injury through Nrf2 signaling pathway in mice , 2017, Free radical research.

[15]  Yanyan Zhang,et al.  Protective Effect of Ginsenoside Rg1 on Hematopoietic Stem/Progenitor Cells through Attenuating Oxidative Stress and the Wnt/β-Catenin Signaling Pathway in a Mouse Model of d-Galactose-induced Aging , 2016, International journal of molecular sciences.

[16]  T. Murohara,et al.  Sodium Sulfide Attenuates Ischemic-Induced Heart Failure by Enhancing Proteasomal Function in an Nrf2-Dependent Manner , 2016, Circulation. Heart failure.

[17]  Chunbing Zhang,et al.  An Antagomir to MicroRNA-106b-5p Ameliorates Cerebral Ischemia and Reperfusion Injury in Rats Via Inhibiting Apoptosis and Oxidative Stress , 2016, Molecular Neurobiology.

[18]  N. Chen,et al.  Ginsenoside Rg1 attenuates motor impairment and neuroinflammation in the MPTP-probenecid-induced parkinsonism mouse model by targeting α-synuclein abnormalities in the substantia nigra. , 2016, Toxicology letters.

[19]  A. Wen,et al.  Posttreatment with 11-Keto-β-Boswellic Acid Ameliorates Cerebral Ischemia–Reperfusion Injury: Nrf2/HO-1 Pathway as a Potential Mechanism , 2015, Molecular Neurobiology.

[20]  A. Kong,et al.  Epigenetic regulation of Keap1-Nrf2 signaling. , 2015, Free radical biology & medicine.

[21]  Bi-Li Zhang,et al.  Inhibiting microRNA-144 abates oxidative stress and reduces apoptosis in hearts of streptozotocin-induced diabetic mice. , 2015, Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology.

[22]  Y. Shi,et al.  Tanshinone IIA protects dopaminergic neurons against 6-hydroxydopamine-induced neurotoxicity through miR-153/NF-E2-related factor 2/antioxidant response element signaling pathway , 2015, Neuroscience.

[23]  F. Mach,et al.  Pathophysiology and Treatments of Oxidative Injury in Ischemic Stroke: Focus on the Phagocytic NADPH Oxidase 2. , 2015, Antioxidants & redox signaling.

[24]  J. Zhen,et al.  Ginsenoside Rg1 ameliorates oxidative stress and myocardial apoptosis in streptozotocin-induced diabetic rats , 2015, Journal of Zhejiang University-SCIENCE B.

[25]  Q. Hou,et al.  Ginsenoside Rg1 protects against transient focal cerebral ischemic injury and suppresses its systemic metabolic changes in cerabral injury rats , 2015, Acta pharmaceutica Sinica. B.

[26]  C. Che,et al.  Recent advances in ginseng as cancer therapeutics: a functional and mechanistic overview. , 2015, Natural product reports.

[27]  J. Gan,et al.  A systematic review and meta-analysis of Ginsenoside-Rg1 (G-Rg1) in experimental ischemic stroke , 2015, Scientific Reports.

[28]  Liang Liu,et al.  Traumatic Brain Injury Dysregulates MicroRNAs to Modulate Cell Signaling in Rat Hippocampus , 2014, PloS one.

[29]  R. Gladstone,et al.  MicroRNA-144 is a circulating effector of remote ischemic preconditioning , 2014, Basic Research in Cardiology.

[30]  N. Chen,et al.  Nrf2 pathway activation contributes to anti-fibrosis effects of ginsenoside Rg1 in a rat model of alcohol- and CCl4-induced hepatic fibrosis , 2014, Acta Pharmacologica Sinica.

[31]  N. Chen,et al.  Neutralization of chemokine-like factor 1, a novel C-C chemokine, protects against focal cerebral ischemia by inhibiting neutrophil infiltration via MAPK pathways in rats , 2014, Journal of Neuroinflammation.

[32]  Ai-ju Liu,et al.  Ginsenoside Rg1 provides neuroprotection against blood brain barrier disruption and neurological injury in a rat model of cerebral ischemia/reperfusion through downregulation of aquaporin 4 expression. , 2014, Phytomedicine : international journal of phytotherapy and phytopharmacology.

[33]  S. Weber,et al.  NRF2-regulation in brain health and disease: Implication of cerebral inflammation , 2014, Neuropharmacology.

[34]  Seung Woo Shin,et al.  Ginsenoside Re Rescues Methamphetamine-Induced Oxidative Damage, Mitochondrial Dysfunction, Microglial Activation, and Dopaminergic Degeneration by Inhibiting the Protein Kinase Cδ Gene , 2014, Molecular Neurobiology.

[35]  Steven C. R. Williams,et al.  Sulforaphane preconditioning of the Nrf2/HO-1 defense pathway protects the cerebral vasculature against blood-brain barrier disruption and neurological deficits in stroke. , 2013, Free radical biology & medicine.

[36]  H. Schmidt,et al.  Neuroprotection after stroke by targeting NOX4 as a source of oxidative stress. , 2013, Antioxidants & redox signaling.

[37]  P. Fraser The role of free radical generation in increasing cerebrovascular permeability. , 2011, Free radical biology & medicine.

[38]  K. Abe,et al.  Expression of Keap1–Nrf2 system and antioxidative proteins in mouse brain after transient middle cerebral artery occlusion , 2011, Brain Research.

[39]  S. Srinivasula,et al.  Nrf2-mediated induction of p62 controls Toll-like receptor-4–driven aggresome-like induced structure formation and autophagic degradation , 2011, Proceedings of the National Academy of Sciences.

[40]  M. Telen,et al.  microRNA miR-144 modulates oxidative stress tolerance and associates with anemia severity in sickle cell disease. , 2010, Blood.

[41]  M. Tang,et al.  Salvianolic acid B improves motor function after cerebral ischemia in rats , 2006, Behavioural pharmacology.

[42]  T. Murphy,et al.  A Small-Molecule-Inducible Nrf2-Mediated Antioxidant Response Provides Effective Prophylaxis against Cerebral Ischemia In Vivo , 2005, The Journal of Neuroscience.

[43]  Lin He,et al.  MicroRNAs: small RNAs with a big role in gene regulation , 2004, Nature Reviews Genetics.

[44]  Lin He,et al.  MicroRNAs: small RNAs with a big role in gene regulation , 2004, Nature Reviews Genetics.

[45]  S. Ashwal,et al.  Core and Penumbral Nitric Oxide Synthase Activity during Cerebral Ischemia and Reperfusion in the Rat Pup , 1999, Pediatric Research.

[46]  S. Ashwal,et al.  Core and penumbral nitric oxide synthase activity during cerebral ischemia and reperfusion. , 1998, Stroke.

[47]  A. Baba,et al.  Edaravone, a radical scavenger, inhibits mitochondrial permeability transition pore in rat brain. , 2007, Journal of pharmacological sciences.

[48]  F. Fang,et al.  Ginsenoside Rg1 reduces MPTP-induced substantia nigra neuron loss by suppressing oxidative stress , 2005, Acta Pharmacologica Sinica.