sex, or baseline MMSE, although those that declined had a significantly higher level of education at baseline (p1⁄4.017). There was a trend for an association of family history and decline, such that 7 out of 8 individuals that declined had a family history, with 6 out of 8 of these subjects having a maternal family history of dementia (p1⁄4.052). There was no significant association between the presence of an ApoE4 allele and decline, in fact no individuals that declined had an ApoE4 allele. Conclusions:While this is a small sample, there is some evidence for the role of a family history, or related genetic associations, in predicting decline in cognition related to Alzheimer’s disease. There is growing evidence in the literature that there is something other than APOE that is possibly determining risk and progression in subjects with a family history of AD.