Principles of Testing for Carcinogenic Activity

[1]  A. Apostolou Relevance of maximum tolerated dose to human carcinogenic risk. , 1990, Regulatory toxicology and pharmacology : RTP.

[2]  E. Oppenheimer,et al.  A COMPARATIVE STUDY OF THE EFFECTS OF IMBEDDING CELLOPHANE AND POLYSTYRENE FILMS IN RATS. , 1964, Cancer research.

[3]  Y Kurokawa,et al.  Validation of transgenic mice carrying the human prototype c-Ha-ras gene as a bioassay model for rapid carcinogenicity testing. , 1998, Environmental health perspectives.

[4]  E Dybing,et al.  T25: a simplified carcinogenic potency index: description of the system and study of correlations between carcinogenic potency and species/site specificity and mutagenicity. , 1997, Pharmacology & toxicology.

[5]  R. Davies,et al.  Photocarcinogenesis Safety Testing , 1993 .

[6]  W. Creutzfeldt,et al.  Efficacy and safety of omeprazole in the long-term treatment of peptic ulcer and reflux oesophagitis resistant to ranitidine. , 1990, Digestion.

[7]  M. Aardema,et al.  The pH 6.7 Syrian hamster embryo cell transformation assay for assessing the carcinogenic potential of chemicals. , 1996, Mutation research.

[8]  Gary M Williams,et al.  The hepatocyte primary culture/DNA repair test using hepatocytes from several species , 1987, Cell Biology and Toxicology.

[9]  G. Williams,et al.  Short- and intermediate-term carcinogenicity testing--a review. Part 2: available experimental models. , 1998, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

[10]  A. Maekawa,et al.  Granular cell foci of the uterus in Donryu rats. , 1998, Journal of comparative pathology.

[11]  K. Keenan Commentary. The uncontrolled variable in risk assessment: ad libitum overfed rodents--fat, facts and fiction. , 1996, Toxicologic pathology.

[12]  P. Wutzler,et al.  Genetic risks of antiviral nucleoside analogues--a survey. , 2001, Antiviral research.

[13]  G. Williams Mechanistic considerations in cancer risk assessment. , 1999, Inhalation toxicology.

[14]  A. Turturro,et al.  Caloric restriction and toxicity. , 1995, Fundamental and applied toxicology : official journal of the Society of Toxicology.

[15]  A. Monro Are lifespan rodent carcinogenicity studies defensible for pharmaceutical agents? , 1996, Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie.

[16]  G. Williams,et al.  Structure-activity relationships in the rat hepatocyte DNA-repair test for 300 chemicals. , 1989, Mutation research.

[17]  A. Hoberman,et al.  Photocarcinogenesis and Consumer Product Testing: Technical Aspects , 1991 .

[18]  J. Haseman,et al.  Analysis of National Toxicology Program rodent bioassay data for anticarcinogenic effects. , 1996, Mutation research.

[19]  A. Rane,et al.  Acetyltransferase in humans: development and tissue distribution. , 1986, Pharmacology.

[20]  V. Dunkel,et al.  Reliability of the hepatocyte primary culture/DNA repair test in testing of coded carcinogens and noncarcinogens. , 1982, Mutation research.

[21]  R. Hallowes,et al.  Tumours of the mammary gland. , 1973, IARC scientific publications.

[22]  G. Williams,et al.  Methods for evaluating chemical genotoxicity. , 1989, Annual review of pharmacology and toxicology.

[23]  B. Lima,et al.  Mechanisms of nongenotoxic carcinogenesis and assessment of the human hazard. , 2000 .

[24]  G. Williams,et al.  DNA reactive and epigenetic carcinogens. , 1992, Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie.

[25]  E. Debruyne,et al.  Phenobarbital, beta-naphthoflavone, clofibrate, and pregnenolone-16alpha-carbonitrile do not affect hepatic thyroid hormone UDP-glucuronosyl transferase activity, and thyroid gland function in mice. , 1999, Toxicology and applied pharmacology.

[26]  C. Capen,et al.  Neoplastic Lesions of Questionable Significance to Humans , 1994, Toxicologic pathology.

[27]  R. Scheuplein,et al.  Permeability of the Skin , 1971 .

[28]  A. Monro,et al.  Veterinary drugs no longer need testing for carcinogenicity in rodent bioassays. , 1998, Regulatory toxicology and pharmacology : RTP.

[29]  C. Powell,et al.  The dose-dependent effect of BHT (butylated hydroxytoluene) on vitamin K-dependent blood coagulation in rats. , 1994, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

[30]  G. Williams,et al.  International cancer risk assessment: the impact of biologic mechanisms. , 1992, Regulatory toxicology and pharmacology : RTP.

[31]  W. Halliwell Submucosal Mesenchymal Tumors of the Mouse Urinary Bladder , 1998, Toxicologic pathology.

[32]  M. Cayen Considerations in the Design of Toxicokinetic Programs , 1995, Toxicologic pathology (Print).

[33]  J. Contrera,et al.  Predicting the carcinogenic potential of pharmaceuticals in rodents using molecular structural similarity and E-state indices. , 2003, Regulatory toxicology and pharmacology : RTP.

[34]  J K Haseman,et al.  Use of statistical decision rules for evaluating laboratory animal carcinogenicity studies. , 1990, Fundamental and applied toxicology : official journal of the Society of Toxicology.

[35]  A. C. Hunter,et al.  Nanomedicine: current status and future prospects , 2005, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[36]  M. Katsuki,et al.  Most tumors in transgenic mice with human c-Ha-ras gene contained somatically activated transgenes. , 1990, Oncogene.

[37]  Karen Blackburn,et al.  Application of the threshold of toxicological concern approach to ingredients in personal and household care products. , 2005, Regulatory toxicology and pharmacology : RTP.

[38]  K. Ruben Gabriel,et al.  A Simple Method of Multiple Comparisons of Means , 1978 .

[39]  James S MacDonald,et al.  Human carcinogenic risk evaluation, part IV: assessment of human risk of cancer from chemical exposure using a global weight-of-evidence approach. , 2004, Toxicological sciences : an official journal of the Society of Toxicology.

[40]  I. White,et al.  Major inter-species differences in the rates of O-sulphonation and O-glucuronylation of alpha-hydroxytamoxifen in vitro: a metabolic disparity protecting human liver from the formation of tamoxifen-DNA adducts. , 2000, Carcinogenesis.

[41]  A. Jacobs Prediction of 2-year carcinogenicity study results for pharmaceutical products: how are we doing? , 2005, Toxicological sciences : an official journal of the Society of Toxicology.

[42]  D. Gaylor,et al.  Dose-response trend tests for tumorigenesis, adjusted for body weight. , 1999, Toxicological sciences : an official journal of the Society of Toxicology.

[43]  L. Wattenberg Chemoprevention of cancer. , 1996, Preventive medicine.

[44]  P. Fenner-Crisp,et al.  Risk assessment of carcinogens in food with special consideration of non-genotoxic carcinogens. Scientific arguments for use of risk assessment and for changing the Delaney Clause specifically. , 1996, Experimental and Toxicological Pathology.

[45]  F. D. de Gruijl,et al.  UV‐induced skin cancer in a hairless mouse model , 1995, BioEssays : news and reviews in molecular, cellular and developmental biology.

[46]  D W Nebert,et al.  P450 superfamily: update on new sequences, gene mapping, accession numbers and nomenclature. , 1996, Pharmacogenetics.

[47]  S. Sieber,et al.  Carrier activity of sonicated small liposomes containing melphalan to regional lymph nodes of rats. , 1983, Pharmacology.

[48]  E. Mcconnell Pathology Requirements for Rodent Two-Year Studies I. A Review of Current Procedures , 1983, Toxicologic pathology.

[49]  V. Riley Psychoneuroendocrine influences on immunocompetence and neoplasia. , 1981, Science.

[50]  C. Capen,et al.  Mechanisms of hormone-mediated carcinogenesis of the ovary in mice. , 1995, Mutation research.

[51]  C. Dunnett A Multiple Comparison Procedure for Comparing Several Treatments with a Control , 1955 .

[52]  J J Gart,et al.  Statistical issues in interpretation of chronic bioassay tests for carcinogenicity. , 1979, Journal of the National Cancer Institute.

[53]  G. Williams,et al.  Safety assessment of butylated hydroxyanisole and butylated hydroxytoluene as antioxidant food additives. , 1999, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

[54]  Dawn G Goodman,et al.  Best Practices Guideline: Toxicologic Histopathology , 2004, Toxicologic pathology.

[55]  G. Williams,et al.  Genotoxicity of carcinogens in human hepatocytes: application in hazard assessment. , 1988, Toxicology and applied pharmacology.

[56]  G. Long,et al.  Precision in Data Acquisition and Reporting of Organ Weights in Rats and Mice , 1998, Toxicologic pathology.

[57]  David Y. Lai,et al.  PPARα Agonist-Induced Rodent Tumors: Modes of Action and Human Relevance , 2003 .

[58]  J. Bucher,et al.  Evaluating the human relevance of chemically induced animal tumors. , 2004, Toxicological sciences : an official journal of the Society of Toxicology.

[59]  R. Eiben,et al.  Trends in mortality, body weights and tumor incidences of Wistar rats over 20 years. , 1999, Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie.

[60]  C. D. Jackson,et al.  2-year Toxicity Study of Doxylamine Succinate in the Fischer 344 Rat , 1993 .

[61]  S. Thorgeirsson,et al.  Contribution of CYP1A1 and CYP1A2 to the activation of heterocyclic amines in monkeys and human. , 1994, Carcinogenesis.

[62]  P. Baldrick Carcinogenicity Evaluation: Comparison of Tumor Data from Dual Control Groups in the Sprague–Dawley Rat , 2005, Toxicologic pathology.

[63]  Chung-Xiou Wang,et al.  Diethylnitrosamine exposure-responses for DNA ethylation, hepatocellular proliferation, and initiation of carcinogenesis in rat liver display non-linearities and thresholds , 1999, Archives of Toxicology.