Pulsed magnetization transfer imaging: evaluation of technique.

With use of an established physical model, numeric simulations were performed to evaluate current imaging protocols for the two primary applications of magnetization transfer: cerebral magnetic resonance angiography and neuroimaging of white matter disease. The authors found that the current technique is appropriate in the former but suboptimal in the latter. Further clinical investigations could potentially improve magnetization protocols for neuroimaging.

[1]  G. Radda,et al.  Oxygenation dependence of the transverse relaxation time of water protons in whole blood at high field. , 1982, Biochimica et biophysica acta.

[2]  M. Schnall,et al.  Magnetization transfer imaging with pulsed off‐resonance saturation: Variation in contrast with saturation duty cycle , 1994, Journal of magnetic resonance imaging : JMRI.

[3]  C. Morrison,et al.  A Model for Magnetization Transfer in Tissues , 1995, Magnetic resonance in medicine.

[4]  Bob S. Hu,et al.  Pulsed magnetization transfer spin‐echo MR imaging , 1993, Journal of magnetic resonance imaging : JMRI.

[5]  E. Purcell,et al.  Effects of Diffusion on Free Precession in Nuclear Magnetic Resonance Experiments , 1954 .

[6]  M Filippi,et al.  A Magnetization Transfer Imaging Study of Normal-Appearing White Matter in Multiple Sclerosis , 1995, Neurology.

[7]  R M Henkelman,et al.  Optimal pulse sequence for imaging hepatic metastases. , 1986, Radiology.

[8]  R. Henkelman,et al.  Understanding pulsed magnetization transfer , 1997, Journal of magnetic resonance imaging : JMRI.

[9]  D L Parker,et al.  MR angiography by multiple thin slab 3D acquisition , 1991, Magnetic resonance in medicine.

[10]  D. Parker,et al.  A quantitative study of ramped radio frequency, magnetization transfer, and slab thickness in three-dimensional time-of-flight magnetic resonance angiography in a patient population. , 1996, Investigative radiology.

[11]  J. Groen,et al.  Fast Field Echo imaging: an overview and contrast calculations. , 1988, Magnetic resonance imaging.

[12]  J C Gore,et al.  Factors influencing contrast in fast spin-echo MR imaging. , 1992, Magnetic resonance imaging.

[13]  Gottfried Otting,et al.  Proton exchange rates from amino acid side chains— implications for image contrast , 1996, Magnetic resonance in medicine.

[14]  D Atkinson,et al.  Improved MR angiography: magnetization transfer suppression with variable flip angle excitation and increased resolution. , 1994, Radiology.

[15]  M Rovaris,et al.  Relation between MR abnormalities and patterns of cognitive impairment in multiple sclerosis , 1998, Neurology.

[16]  Elliot R. Mcveigh,et al.  Optimization of survey protocols for mri , 1990, Magnetic resonance in medicine.

[17]  R I Grossman,et al.  Quantitative volumetric magnetization transfer analysis in multiple sclerosis: Estimation of macroscopic and microscopic disease burden , 1996, Magnetic resonance in medicine.

[18]  Albert Macovski,et al.  Estimating oxygen saturation of blood in vivo with MR imaging at 1.5 T , 1991 .

[19]  S. Meiboom,et al.  Modified Spin‐Echo Method for Measuring Nuclear Relaxation Times , 1958 .

[20]  R M Henkelman,et al.  Quantitative interpretation of magnetization transfer , 1993, Magnetic resonance in medicine.

[21]  H. Steinmetz,et al.  Intracranial stenoocclusive disease: MR angiography with magnetization transfer and variable flip angle. , 1996, AJNR. American journal of neuroradiology.

[22]  G E Santyr,et al.  Magnetization transfer effects in multislice MR imaging. , 1993, Magnetic resonance imaging.

[23]  B D Ross,et al.  Absolute Quantitation of Water and Metabolites in the Human Brain. I. Compartments and Water , 1993 .

[24]  R I Grossman,et al.  Microscopic disease in normal-appearing white matter on conventional MR images in patients with multiple sclerosis: assessment with magnetization-transfer measurements. , 1995, Radiology.

[25]  R M Henkelman,et al.  A flexible magnetization transfer line shape derived from tissue experimental data , 1997, Magnetic resonance in medicine.

[26]  R M Henkelman,et al.  Relaxivity and magnetization transfer of white matter lipids at MR imaging: importance of cerebrosides and pH. , 1994, Radiology.

[27]  Bob S. Hu,et al.  Magnetization transfer time‐of‐flight magnetic resonance angiography , 1992, Magnetic resonance in medicine.

[28]  G. C. Hurst,et al.  Cerebral white matter: technical development and clinical applications of effective magnetization transfer (MT) power concepts for high-power, thin-section, quantitative MT examinations. , 1996, Radiology.

[29]  R I Grossman,et al.  Magnetization transfer: theory and clinical applications in neuroradiology. , 1994, Radiographics : a review publication of the Radiological Society of North America, Inc.

[30]  D L Parker,et al.  Experimental and theoretical studies of vessel contrast‐to‐noise ratio in intracranial time‐of‐flight MR angiography , 1996, Journal of magnetic resonance imaging : JMRI.

[31]  J Hua,et al.  Analysis of on‐ and off‐resonance magnetization transfer techniques , 1995, Journal of magnetic resonance imaging : JMRI.

[32]  H. Aronen,et al.  Spin lock and magnetization transfer imaging of head and neck tumors. , 1996, Radiology.

[33]  F. Barkhof,et al.  Magnetization transfer contrast (MTC) and long repetition time spin-echo MR imaging in multiple sclerosis. , 1998, Magnetic resonance imaging.