Dispersible hydrogel force sensors reveal patterns of solid mechanical stress in multicellular spheroid cultures

[1]  J. Zahn,et al.  Coherent Timescales and Mechanical Structure of Multicellular Aggregates. , 2018, Biophysical journal.

[2]  Ning Wang,et al.  Quantifying compressive forces between living cell layers and within tissues using elastic round microgels , 2018, Nature Communications.

[3]  W. Muller,et al.  Progressive polarity loss and luminal collapse disrupt tissue organization in carcinoma , 2017, Genes & development.

[4]  F. Ingremeau,et al.  Optical sensing of mechanical pressure based on diffusion measurement in polyacrylamide cell-like barometers. , 2017, Soft matter.

[5]  J. Prost,et al.  Cell-like pressure sensors reveal increase of mechanical stress towards the core of multicellular spheroids under compression , 2017, Nature Communications.

[6]  Dai Fukumura,et al.  Solid stress and elastic energy as measures of tumour mechanopathology , 2016, Nature Biomedical Engineering.

[7]  Christian Stüllein,et al.  Evaluation of Consistency in Spheroid Invasion Assays , 2016, Scientific Reports.

[8]  Junmin Lee,et al.  Interfacial geometry dictates cancer cell tumorigenicity. , 2016, Nature materials.

[9]  B. Fabry,et al.  Three-dimensional force microscopy of cells in biopolymer networks , 2015, Nature Methods.

[10]  Andrew S. LaCroix,et al.  Molecular-Scale Tools for Studying Mechanotransduction. , 2015, Annual review of biomedical engineering.

[11]  James C. Weaver,et al.  Hydrogels with tunable stress relaxation regulate stem cell fate and activity , 2015, Nature materials.

[12]  Lauren E. Jansen,et al.  Mechanics of intact bone marrow. , 2015, Journal of the mechanical behavior of biomedical materials.

[13]  Brendon M. Baker,et al.  Cell-mediated fiber recruitment drives extracellular matrix mechanosensing in engineered fibrillar microenvironments , 2015, Nature materials.

[14]  Y. Shao,et al.  Supersoft lithography: candy-based fabrication of soft silicone microstructures. , 2015, Lab on a chip.

[15]  Kelly M. Schultz,et al.  Measuring dynamic cell–material interactions and remodeling during 3D human mesenchymal stem cell migration in hydrogels , 2015, Proceedings of the National Academy of Sciences.

[16]  François Nédélec,et al.  Pulsatile cell-autonomous contractility drives compaction in the mouse embryo , 2015, Nature Cell Biology.

[17]  Stephanie L. Ham,et al.  Robotic production of cancer cell spheroids with an aqueous two-phase system for drug testing. , 2015, Journal of visualized experiments : JoVE.

[18]  D. Mooney,et al.  Substrate stress relaxation regulates cell spreading , 2015, Nature Communications.

[19]  Araxi O. Urrutia,et al.  YAP is essential for tissue tension to ensure vertebrate 3D body shape , 2015, Nature.

[20]  Frank Jülicher,et al.  Stress distributions and cell flows in a growing cell aggregate , 2014, Interface Focus.

[21]  David R. Liu,et al.  A DNA-based molecular probe for optically reporting cellular traction forces , 2014, Nature Methods.

[22]  E. Darling,et al.  3D Viscoelastic traction force microscopy. , 2014, Soft matter.

[23]  Dapeng Bi,et al.  A density-independent rigidity transition in biological tissues , 2014, Nature Physics.

[24]  David J. Caldwell,et al.  Noninvasive Quantification of In Vitro Osteoblastic Differentiation in 3D Engineered Tissue Constructs Using Spectral Ultrasound Imaging , 2014, PloS one.

[25]  Donald E Ingber,et al.  Quantifying cell-generated mechanical forces within living embryonic tissues , 2013, Nature Methods.

[26]  Jason P. Gleghorn,et al.  Quantitative approaches to uncover physical mechanisms of tissue morphogenesis. , 2013, Current opinion in biotechnology.

[27]  Marcos Lanio,et al.  Glassy dynamics in three-dimensional embryonic tissues , 2013, Journal of The Royal Society Interface.

[28]  Saloni R. Jain,et al.  Coevolution of solid stress and interstitial fluid pressure in tumors during progression: implications for vascular collapse. , 2013, Cancer research.

[29]  Thomas Lecuit,et al.  Mechanics of Epithelial Tissue Homeostasis and Morphogenesis , 2013, Science.

[30]  J. Brenton,et al.  Complex Stiffness Gradient Substrates for Studying Mechanotactic Cell Migration , 2012, Advanced materials.

[31]  Jason P. Gleghorn,et al.  Host epithelial geometry regulates breast cancer cell invasiveness , 2012, Proceedings of the National Academy of Sciences.

[32]  Triantafyllos Stylianopoulos,et al.  Causes, consequences, and remedies for growth-induced solid stress in murine and human tumors , 2012, Proceedings of the National Academy of Sciences.

[33]  Jason P. Gleghorn,et al.  Sculpting organs: mechanical regulation of tissue development. , 2012, Annual review of biomedical engineering.

[34]  Cheri X Deng,et al.  Noninvasive, quantitative, spatiotemporal characterization of mineralization in three-dimensional collagen hydrogels using high-resolution spectral ultrasound imaging. , 2012, Tissue engineering. Part C, Methods.

[35]  Casey M. Kraning-Rush,et al.  Cellular Traction Stresses Increase with Increasing Metastatic Potential , 2012, PloS one.

[36]  Thomas Boudou,et al.  A microfabricated platform to measure and manipulate the mechanics of engineered cardiac microtissues. , 2012, Tissue engineering. Part A.

[37]  Rakesh K Jain,et al.  Mechanical compression drives cancer cells toward invasive phenotype , 2011, Proceedings of the National Academy of Sciences.

[38]  Nicola Elvassore,et al.  Role of YAP/TAZ in mechanotransduction , 2011, Nature.

[39]  Wesley R. Legant,et al.  Measurement of mechanical tractions exerted by cells in three-dimensional matrices , 2010, Nature Methods.

[40]  M. Bönstrup,et al.  Development of a Drug Screening Platform Based on Engineered Heart Tissue , 2010, Circulation research.

[41]  Christopher S. Chen,et al.  Measuring mechanical tension across vinculin reveals regulation of focal adhesion dynamics , 2010, Nature.

[42]  Donald E Ingber,et al.  Mechanical control of tissue and organ development , 2010, Development.

[43]  G. Ateshian,et al.  Continuum modeling of biological tissue growth by cell division, and alteration of intracellular osmolytes and extracellular fixed charge density. , 2009, Journal of biomechanical engineering.

[44]  Christopher S. Chen,et al.  Microfabricated tissue gauges to measure and manipulate forces from 3D microtissues , 2009, Proceedings of the National Academy of Sciences.

[45]  David A. Weitz,et al.  Physical forces during collective cell migration , 2009 .

[46]  Kristi S. Anseth,et al.  Photodegradable Hydrogels for Dynamic Tuning of Physical and Chemical Properties , 2009, Science.

[47]  L. Davidson,et al.  Actomyosin stiffens the vertebrate embryo during crucial stages of elongation and neural tube closure , 2009, Development.

[48]  Lieven Thorrez,et al.  Drug‐screening platform based on the contractility of tissue‐engineered muscle , 2008, Muscle & nerve.

[49]  Frank Jülicher,et al.  Quantitative differences in tissue surface tension influence zebrafish germ layer positioning , 2008, HFSP journal.

[50]  R. K. Shah,et al.  Monodisperse Thermoresponsive Microgels with Tunable Volume‐Phase Transition Kinetics , 2007 .

[51]  Daniel A Fletcher,et al.  Tissue Geometry Determines Sites of Mammary Branching Morphogenesis in Organotypic Cultures , 2006, Science.

[52]  M. Sheetz,et al.  Local force and geometry sensing regulate cell functions , 2006, Nature Reviews Molecular Cell Biology.

[53]  P. Janmey,et al.  Tissue Cells Feel and Respond to the Stiffness of Their Substrate , 2005, Science.

[54]  R. Austin,et al.  Force mapping in epithelial cell migration. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[55]  P. Janmey,et al.  Nonlinear elasticity in biological gels , 2004, Nature.

[56]  K. Beningo,et al.  Fc-receptor-mediated phagocytosis is regulated by mechanical properties of the target. , 2002, Journal of cell science.

[57]  W. Zimmermann,et al.  Three-dimensional engineered heart tissue from neonatal rat cardiac myocytes. , 2000, Biotechnology and bioengineering.

[58]  I. Jasiuk,et al.  A Spherical Inclusion in an Elastic Half-Space Under Shear , 1997 .

[59]  B. Torok-Storb,et al.  Functionally distinct human marrow stromal cell lines immortalized by transduction with the human papilloma virus E6/E7 genes. , 1995, Blood.

[60]  K. Jacobson,et al.  Traction forces generated by locomoting keratocytes , 1994, The Journal of cell biology.

[61]  Zhibing Hu,et al.  New method for measuring Poisson's ratio in polymer gels , 1993 .

[62]  R. Crowninshield,et al.  Finite Elements in Biomechanics , 1982 .

[63]  A. Harris,et al.  Silicone rubber substrata: a new wrinkle in the study of cell locomotion. , 1980, Science.

[64]  Benjamin J. Ellis,et al.  FEBio: finite elements for biomechanics. , 2012, Journal of biomechanical engineering.

[65]  Thomas Boudou,et al.  Nonlinear elastic properties of polyacrylamide gels: implications for quantification of cellular forces. , 2009, Biorheology.

[66]  Christopher S. Chen,et al.  Mechanotransduction in development: a growing role for contractility , 2009, Nature Reviews Molecular Cell Biology.