Mutagenicity of amino acid and glutathione S-conjugates in the Ames test.

[1]  W. Dekant,et al.  Enzymatic transformation of mercapturic acids derived from halogenated alkenes to reactive and mutagenic intermediates. , 1987, Biochemical pharmacology.

[2]  L. Lash,et al.  Alpha-ketoacids stimulate rat renal cysteine conjugate beta-lyase activity and potentiate the cytotoxicity of S-(1,2-dichlorovinyl)-L-cysteine. , 1987, Molecular Pharmacology.

[3]  L. Lash,et al.  S-(1,2-dichlorovinyl)-L-homocysteine-induced cytotoxicity in isolated rat kidney cells. , 1986, Archives of biochemistry and biophysics.

[4]  W. Dekant,et al.  Bacterial beta-lyase mediated cleavage and mutagenicity of cysteine conjugates derived from the nephrocarcinogenic alkenes trichloroethylene, tetrachloroethylene and hexachlorobutadiene. , 1986, Chemico-biological interactions.

[5]  L. Lash,et al.  Cytotoxicity of S-(1,2-dichlorovinyl)glutathione and S-(1,2-dichlorovinyl)-L-cysteine in isolated rat kidney cells. , 1986, The Journal of biological chemistry.

[6]  M. Metzler,et al.  Identification of S-1,2-dichlorovinyl-N-acetyl-cysteine as a urinary metabolite of trichloroethylene: a possible explanation for its nephrocarcinogenicity in male rats. , 1986, Biochemical pharmacology.

[7]  L. Lash,et al.  Metabolic activation and detoxication of nephrotoxic cysteine and homocysteine S-conjugates. , 1986, Proceedings of the National Academy of Sciences of the United States of America.

[8]  M. W. Anders,et al.  Mechanism of S-(1,2-dichlorovinyl)glutathione-induced nephrotoxicity. , 1986, Biochemical pharmacology.

[9]  L. Lash,et al.  Nephrotoxicity of S-(2-chloro-1,1,2-trifluoroethyl)glutathione and S-(2-chloro-1,1,2-trifluoroethyl)-L-cysteine, the glutathione and cysteine conjugates of chlorotrifluoroethene. , 1985, The Journal of pharmacology and experimental therapeutics.

[10]  M. W. Anders,et al.  Renal processing of glutathione conjugates. Role in nephrotoxicity. , 1984, Biochemical pharmacology.

[11]  B. Ames,et al.  Revised methods for the Salmonella mutagenicity test. , 1983, Mutation research.

[12]  M. W. Anders,et al.  Assay of cysteine conjugate beta-lyase activity with S-(2-benzothiazolyl)cysteine as the substrate. , 1982, Analytical biochemistry.

[13]  A. J. Gandolfi,et al.  Nephrotoxicity of halogenated vinyl cysteine compounds. , 1981, Research communications in chemical pathology and pharmacology.

[14]  D. J. Reed,et al.  The inhibition of γ-glutamyl transpeptidase and glutathione metabolism of isolated rat kidney cells by L-(αS, 5S)-α-amino-3-chloro-4, 5-dihydro-5-isoxazoleacetic acid (AT-125; NSC-163501) , 1980 .

[15]  R. K. Bhattacharya,et al.  Properties of DNA treated with S-(1,2-dichlorovinyl)-L-cysteine and a lyase. , 1972, Archives of biochemistry and biophysics.

[16]  M. Stonard,et al.  The metabolism of S-(1,2 dichlorovinyl)-L-cysteine by rat liver mitochondria. , 1971, Biochemical pharmacology.

[17]  P. Anderson,et al.  Cleavage of S-(1,2-dichlorovinyl)-L-cysteine by an enzyme of bovine origin. , 1965, Archives of biochemistry and biophysics.

[18]  J. Picken,et al.  Possible Toxic Factor of Trichloroethylene-extracted Soybean Oil Meal3 , 1959 .

[19]  V. Du Vigneaud,et al.  alpha-Ketobutyric acid as a product in the enzymatic cleavage of cystathionine. , 1949, The Journal of biological chemistry.

[20]  W. Dekant,et al.  Biosynthesis and biotransformation of glutathione S-conjugates to toxic metabolites. , 1988, Critical reviews in toxicology.

[21]  L. Lash,et al.  Nephrotoxic amino acid and glutathione S-conjugates: formation and renal activation. , 1986, Advances in experimental medicine and biology.

[22]  J. Odum,et al.  Structure/activity studies of the nephrotoxic and mutagenic action of cysteine conjugates of chlgro and fluoroalkenes , 1985 .

[23]  B. Terracini,et al.  A PATHOLOGICAL STUDY ON THE TOXICITY OF S-DICHLOROVINYL-L-CYSTEINE. , 1965, Food and cosmetics toxicology.